公开(公告)号：CA1335788C

公开(公告)日：1995-06-06

申请号：CA567994

申请日：1988-05-27

Applicant: SURVIVAL TECHNOLOGY

Inventor： SARNOFF STANLEY J ,  SOBEL BURTON E

IPC: A61K38/46 ,  A61K31/415 ,  A61K38/38 ,  A61K38/49 ,  A61K47/16 ,  A61K47/18 ,  A61P7/02 ,  A61K37/547

Abstract: A package containing (1) t-PA, (2) methylamine or a non-toxic salt thereof, and (3) hydroxylamine or a non-toxic salt thereof, the amount of hydroxylamine or non-toxic salt thereof being sufficient to increase the absorption in the blood of the t-PA when it is administered nonintravascularly to a mammal and the amount of methylamine or non-toxic salt thereof being sufficient to reduce the amount of hydroxylamine or non-toxic salt thereof required to obtain the increased absorption of t-PA and a method for intramuscularly administering the same.

公开(公告)号：CA1264030A

公开(公告)日：1989-12-27

申请号：CA488317

申请日：1985-08-08

Applicant: SURVIVAL TECHNOLOGY

Inventor： SARNOFF STANLEY J ,  SOBEL BURTON E

IPC: A61K31/13 ,  A61K31/415 ,  A61K38/38 ,  A61K38/44 ,  A61K38/49 ,  A61K47/18 ,  A61M5/19 ,  A61K37/02

Abstract: 37 The absorption rate of proteins with medicinal properties in the blood is enhanced by administering the protein intramuscularly together with an absorption enhancing agent, preferably hydroxylamine or a salt thereof, most preferably hydroxylamine hydrochloride.

公开(公告)号：FI864480A0

公开(公告)日：1986-11-04

申请号：FI864480

申请日：1986-11-04

Applicant: SURVIVAL TECHNOLOGY

Inventor： SARNOFF STANLEY JAY ,  SOBEL BURTON E

IPC: A61K20060101 ,  A61K31/415 ,  A61K38/38 ,  A61K38/49 ,  A61K47/18 ,  A61K

公开(公告)号：AU5581186A

公开(公告)日：1986-09-24

申请号：AU5581186

申请日：1986-03-06

Applicant: SURVIVAL TECHNOLOGY

Inventor： SARNOFF STANLEY JAY ,  SOBEL BURTON E

IPC: A61K20060101 ,  A61K31/415 ,  A61K38/38 ,  A61K38/49 ,  A61K47/18 ,  A61K37/02

公开(公告)号：AU1616488A

公开(公告)日：1988-12-01

申请号：AU1616488

申请日：1988-05-16

Applicant: SURVIVAL TECHNOLOGY

Inventor： SARNOFF STANLEY JAY ,  SOBEL BURTON E

IPC: A61K38/46 ,  A61K31/415 ,  A61K38/38 ,  A61K38/49 ,  A61K47/16 ,  A61K47/18 ,  A61P7/02 ,  A61K47/00 ,  A61K37/547

Abstract: A package containing (1) t-PA, (2) methylamine or a non-toxic salt thereof, and (3) hydroxylamine or a non-toxic salt thereof, the amount of hydroxylamine or non-toxic salt thereof being sufficient to increase the absorption in the blood of the t-PA when it is administered non-intravascularly to a mammal and the amount of methylamine or non-toxic salt thereof being sufficient to reduce the amount of hydroxylamine or non-toxic salt thereof required to obtain the increased absorption of t-PA and a method for intramuscularly administering the same.

公开(公告)号：DK528386D0

公开(公告)日：1986-11-05

申请号：DK528386

申请日：1986-11-05

Applicant: SURVIVAL TECHNOLOGY

Inventor： SARNOFF STANLEY JAY ,  SOBEL BURTON E

IPC: A61K20060101 ,  A61K31/415 ,  A61K38/38 ,  A61K38/49 ,  A61K47/18 ,  A61K

公开(公告)号：PT82277A

公开(公告)日：1986-04-01

申请号：PT8227786

申请日：1986-03-26

Applicant: SURVIVAL TECHNOLOGY

Inventor： SARNOFF STANLEY JAY ,  SOBEL BURTON E

IPC: A61K20060101 ,  A61K47/00 ,  C12N9/48 ,  C07K15/00

Abstract: The absorption of a therapeutically active protein (I) in the blood is improved by intramuscular injection of (I) together with an absorption enhancing agent (II). Particularly, the method is used where (I) has a short in vivo half-life and allows an effective concn. to be maintained for at least 30 min. Also new are packages contg. (I) and (II).

公开(公告)号：AT80306T

公开(公告)日：1992-09-15

申请号：AT86902132

申请日：1986-03-06

Applicant: SURVIVAL TECHNOLOGY

Inventor： SARNOFF STANLEY JAY ,  SOBEL BURTON E

IPC: A61K20060101 ,  A61K31/415 ,  A61K38/38 ,  A61K38/49 ,  A61K47/18 ,  A61K37/02

公开(公告)号：AU627125B2

公开(公告)日：1992-08-13

申请号：AU1616488

申请日：1988-05-16

Applicant: SURVIVAL TECHNOLOGY

Inventor： SARNOFF STANLEY JAY ,  SOBEL BURTON E

IPC: A61K38/46 ,  A61K31/415 ,  A61K38/38 ,  A61K38/49 ,  A61K47/16 ,  A61K47/18 ,  A61P7/02 ,  A61K37/547

Abstract: A package containing (1) t-PA, (2) methylamine or a non-toxic salt thereof, and (3) hydroxylamine or a non-toxic salt thereof, the amount of hydroxylamine or non-toxic salt thereof being sufficient to increase the absorption in the blood of the t-PA when it is administered non-intravascularly to a mammal and the amount of methylamine or non-toxic salt thereof being sufficient to reduce the amount of hydroxylamine or non-toxic salt thereof required to obtain the increased absorption of t-PA and a method for intramuscularly administering the same.

公开(公告)号：AU5357290A

公开(公告)日：1991-10-30

申请号：AU5357290

申请日：1990-03-30

Applicant: SURVIVAL TECHNOLOGY

Inventor： SARNOFF STANLEY JAY ,  SOBEL BURTON E

IPC: C12N9/50 ,  A61K37/547 ,  A61K37/02 ,  C07K15/00