公开(公告)号：WO2015031956A1

公开(公告)日：2015-03-12

申请号：PCT/AU2014/050211

申请日：2014-09-05

Applicant: SWINBURNE UNIVERSITY OF TECHNOLOGY

Inventor： JUODKAZIS, Saulius ,  IVANOVA, Elena

IPC: B82Y30/00 ,  B82Y5/00 ,  B82B3/00 ,  C12N1/06 ,  H01L21/3065

CPC classification number: A01N25/34 ,  B82Y5/00 ,  B82Y30/00 ,  C12N1/066 ,  C12Q1/24

Abstract: H:\sxd\Interwoven\NRPortbl\DCC\SXD\6709386_1.doc-5/09/2014 - 40 - ABSTRACT The invention relates to materials that exhibit biocidal activity and in particular to surfaces that exhibit novel surface topography that is lethal to cells on contact. The invention also relates to devices comprising such surfaces, to methods of producing the surfaces and to methods of eliminating or reducing cellular survival wherein cells are exposed to the surfaces. In particular the invention relates to a synthetic biocidal surface comprising an array of nanospikes that are lethal to cells on said surface due to piercing of cell membranes by said nanospikes and to a method of producing a synthetic biocidal surface comprising an array of nanospikes that are lethal to cells on said surface due to piercing of cell membranes by said nanospikes, which comprises exposing a silicon comprising substrate surface to reactive-ion etching.

Abstract translation: H：\ sxd \ Interwoven \ NRPortbl \ DCC \ SXD \ 6709386_1.doc-5/09/2014 - 40 - 摘要本发明涉及显示杀生物活性的材料，特别是涉及表现出对细胞致死的新颖表面形貌的表面 联系。 本发明还涉及包括这种表面的装置，产生表面的方法以及消除或减少细胞存活的方法，其中细胞暴露于表面。 特别地，本发明涉及一种合成杀生物表面，其包括由于所述纳米球的刺穿细胞膜而对所述表面上的细胞致死的纳米球的阵列，以及产生包含致死性的纳米尺度阵列的合成杀生物表面的方法 由于所述纳米尺度刺穿细胞膜，所述表面上的细胞包括将包含硅的基底表面暴露于反应离子蚀刻。

公开(公告)号：EP3041787A1

公开(公告)日：2016-07-13

申请号：EP14841944.3

申请日：2014-09-05

Applicant: Swinburne University of Technology

Inventor： JUODKAZIS, Saulius ,  IVANOVA, Elena

IPC: B82Y30/00 ,  B82Y5/00 ,  B82B3/00 ,  C12N1/06 ,  H01L21/3065

Abstract: The invention relates to materials that exhibit biocidal activity and in particular to surfaces that exhibit novel surface topography that is lethal to cells on contact. The invention also relates to devices comprising such surfaces, to methods of producing the surfaces and to methods of eliminating or reducing cellular survival wherein cells are exposed to the surfaces. In particular the invention relates to a synthetic biocidal surface comprising an array of nanospikes that are lethal to cells on said surface due to piercing of cell membranes by said nanospikes and to a method of producing a synthetic biocidal surface comprising an array of nanospikes that are lethal to cells on said surface due to piercing of cell membranes by said nanospikes, which comprises exposing a silicon comprising substrate surface to reactive-ion etching.