公开(公告)号：JP2008224686A

公开(公告)日：2008-09-25

申请号：JP2008140198

申请日：2008-05-28

Applicant: Symyx Technologies Inc ,  サイミックス テクノロジーズ, インコーポレイテッド

Inventor： CARLSON ERIC D ,  CONG PEIJUN ,  CHANDLER WILLIAM H JR ,  CHAU HENRY K ,  DANIELSON EARL ,  DESROSIERS PETER J ,  DOOLAN ROBERT D ,  WU LUPING

IPC: G01N21/64 ,  G01N33/50 ,  B01J19/00 ,  B01L3/00 ,  B01L3/06 ,  B01L7/00 ,  C07B61/00 ,  C07D209/20 ,  C07D293/00 ,  C40B40/10 ,  C40B60/08 ,  C40B60/14 ,  G01N5/04 ,  G01N13/00 ,  G01N21/23 ,  G01N21/27 ,  G01N21/33 ,  G01N21/35 ,  G01N21/47 ,  G01N21/65 ,  G01N21/78 ,  G01N24/08 ,  G01N25/04 ,  G01N30/88 ,  G01N33/15 ,  G01N33/483 ,  G01N33/53 ,  G01N33/543 ,  G01N35/02 ,  G01N37/00

CPC classification number: B01L3/50255 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/00423 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00725 ,  B01J2219/00756 ,  B01L3/06 ,  B01L7/00 ,  B01L2300/0829 ,  B01L2300/185 ,  C40B40/04 ,  C40B40/10 ,  C40B60/10 ,  C40B60/14 ,  G01N5/045 ,  G01N21/23 ,  G01N21/65 ,  G01N25/04 ,  G01N33/15 ,  G01N33/54366 ,  G01N35/028 ,  G01N2013/006 ,  G01N2021/651 ,  G01N2500/00 ,  G06F19/703 ,  G06F19/709 ,  Y10T117/10

Abstract: PROBLEM TO BE SOLVED: To provide a methods, an apparatus, and a system for performing a high-throughput preparation and a screening of salts and polymorphs of drug candidates. SOLUTION: The method is directed toward enhancing the pre-formulation discovery process used for a drug development. In particular, processes of determining suitable salts and processes of discovering substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members from, for example, a library model generated by a computer system. COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：提供用于进行药物候选物的盐和多晶型物的高通量制备和筛选的方法，装置和系统。 解决方案：该方法旨在增强用于药物开发的预配制发现过程。 特别地，提供了确定合适的盐和基本上发现可以从特定药物候选物形成的每个多晶型物的过程的方法。 使用特定配置为在高吞吐量表征过程中执行各种步骤的几个装置来执行处理。 一种这样的装置被配置为从例如由计算机系统生成的库模型合成多个库成员。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：AU2002367984A8

公开(公告)日：2003-12-12

申请号：AU2002367984

申请日：2002-05-23

Applicant: SYMYX TECHNOLOGIES INC ,  RHODIA CHIMIE SA

Inventor： CARLSON ERIC D ,  CREVIER THOMAS ,  GIRAUD YVES ,  POINTE ANNE-MARIE LA ,  STERIN SEBASTIEN ,  BRUMMER OLIVER

IPC: B01J31/22 ,  C07F7/18 ,  C07F15/00 ,  C07F19/00 ,  C08G77/08 ,  C08G77/398 ,  C08K5/34 ,  C08L83/04 ,  C08L83/05 ,  C08L83/07

Abstract: This invention relates to silicone compositions which can be crosslinked, preferably into elastomers, by hydrosilylation of at least one PolyOrganoSiloxane -A- carrying unsaturated bonds, using at least one polyorganohydrosiloxane -B- in the presence of a carbene-based metal catalyst -C- as defined in the description and which optionally comprises at least one inhibitor -D- of the hydrosilylation reaction.

公开(公告)号：DE60229443D1

公开(公告)日：2008-11-27

申请号：DE60229443

申请日：2002-05-23

Applicant: RHODIA CHIMIE SA ,  SYMYX TECHNOLOGIES INC

Inventor： BRUMMER OLIVER ,  CARLSON ERIC D ,  CREVIER THOMAS ,  GIRAUD YVES ,  LA POINTE ANNE-MARIE ,  STERIN SEBASTIEN

IPC: B01J31/22 ,  C07F7/18 ,  C08G77/08 ,  C07F15/00 ,  C07F19/00 ,  C08G77/398 ,  C08K5/34 ,  C08L83/04 ,  C08L83/05 ,  C08L83/07

Abstract: This invention relates to silicone compositions which can be crosslinked, preferably into elastomers, by hydrosilylation of at least one PolyOrganoSiloxane -A- carrying unsaturated bonds, using at least one polyorganohydrosiloxane -B- in the presence of a carbene-based metal catalyst -C- as defined in the description and which optionally comprises at least one inhibitor -D- of the hydrosilylation reaction.

公开(公告)号：BR0213905A

公开(公告)日：2004-08-31

申请号：BR0213905

申请日：2002-11-06

Applicant: BASF AG ,  SYMYX TECHNOLOGIES INC

Inventor： KOLTZENBURG SEBASTIAN ,  SCHROF WOLFGANG ,  SEUFERT MICHAEL ,  HEGER ROBERT ,  LEHMANN STEPHAN ,  KARDORFF UWE ,  ZAGAR CYRILL ,  BRATZ MATTHIAS ,  CARLSON ERIC D ,  CHANG HAN TING ,  KUEBLER SIGRID C

IPC: A01N43/38 ,  A01N25/04 ,  A01N25/10 ,  A01N37/32 ,  A01N37/46 ,  C08F220/60

Abstract: The invention relates to a solid crop protection formulation comprising a) cinidon-ethyl as a crop protection agent; b) at least one random radical copolymer comprising as polymerized units at least one hydrophilic and at least one hydrophobic monomer; and c) optionally further additives, wherein at least 50% of the dispersed cinidon-ethyl particles in said solid crop protection formulation are in an X-ray amorphous state and an aqueous dispersion formulation thereof. Additionally, the invention relates to processes for preparing said formulations and the use of said formulations in agriculture. Further, the invention relates to a random radical copolymer essentially consisting of as polymerized units a) 5 to 95% by weight of styrene as component A; b) 5 to 95% by weight of DMAPMAM (dimethylaminopropyl methacrylic amide) as component B; c) 0 to 98% by weight of methyl acrylate and/or vinyl acetate as component C.

公开(公告)号：AU2003241307A8

公开(公告)日：2003-12-12

申请号：AU2003241307

申请日：2003-04-23

Applicant: SYMYX TECHNOLOGIES INC

Inventor： KOLOSOV OLEG ,  MAZZOLA LAURA T ,  CARLSON ERIC D ,  GALLIPEO JOHN ,  MATSIEV LEONID ,  SPITKOVSKY MIKHAIL

IPC: G01G3/13 ,  G01N5/04 ,  G01N33/15 ,  G01N27/00 ,  B01J19/00 ,  G01G3/16

Abstract: A method and apparatus for measurement of mass of small sample sizes. The method and apparatus is particularly adapted for providing microbalance measurement of solid materials as part of a combinatorial research program. The method and apparatus contemplate monitoring the response of a resonator holding a sample and correlating the response with mass change in the samples.

公开(公告)号：AU2003241307A1

公开(公告)日：2003-12-12

申请号：AU2003241307

申请日：2003-04-23

Applicant: SYMYX TECHNOLOGIES INC

Inventor： CARLSON ERIC D ,  KOLOSOV OLEG ,  MATSIEV LEONID ,  MAZZOLA LAURA T ,  SPITKOVSKY MIKHAIL ,  GALLIPEO JOHN

IPC: G01G3/13 ,  G01N5/04 ,  G01N33/15 ,  G01N19/00

Abstract: A method and apparatus for measurement of mass of small sample sizes. The method and apparatus is particularly adapted for providing microbalance measurement of solid materials as part of a combinatorial research program. The method and apparatus contemplate monitoring the response of a resonator holding a sample and correlating the response with mass change in the samples.

公开(公告)号：AU2003229291A1

公开(公告)日：2004-01-06

申请号：AU2003229291

申请日：2003-05-15

Applicant: SYMYX TECHNOLOGIES INC

Inventor： GIAQUINTA DANIEL M ,  CARLSON ERIC D

IPC: G01N23/20 ,  B01J19/00 ,  G01N23/00

Abstract: A method for characterization of a solid material sample, including the steps of providing a liquid medium for delivering a solid material sample to a porous substrate. Solid sample is separated from the liquid medium by filtering through the porous substrate. Analysis such as x-ray analysis of the solid sample is conducted while the sample resides on the porous substrate.

公开(公告)号：AU2002226403A1

公开(公告)日：2003-06-30

申请号：AU2002226403

申请日：2001-12-19

Applicant: POINTE ANNE MARIE ,  RHODIA CHIMIE SA ,  SYMYX TECHNOLOGIES INC

Inventor： CARLSON ERIC D ,  CREVIER THOMAS ,  GIRAUD YVES ,  STERIN SEBASTIEN

IPC: C08L83/05 ,  C08G77/08 ,  C08K5/00 ,  C08K5/3442 ,  C08L83/04 ,  C08L83/07 ,  C08K5/098 ,  C08K5/56

公开(公告)号：AU2002226401A1

公开(公告)日：2003-06-23

申请号：AU2002226401

申请日：2001-12-11

Applicant: RHODIA CHIMIE SA ,  SYMYX TECHNOLOGIES INC

Inventor： BRUMMER OLIVER ,  CARLSON ERIC D ,  CREVIER THOMAS ,  GIRAUD YVES ,  POINTE ANNE-MARIE LA ,  STERIN SEBASTIEN

IPC: C08K5/00 ,  C08K5/3432 ,  C08L83/04

公开(公告)号：WO03021251A9

公开(公告)日：2003-10-16

申请号：PCT/US0227629

申请日：2002-08-28

Applicant: SYMYX TECHNOLOGIES INC ,  PETRO MIROSLAV ,  NGUYEN SON HOAI ,  CARLSON ERIC D

Inventor： PETRO MIROSLAV ,  NGUYEN SON HOAI ,  CARLSON ERIC D

IPC: B01D15/26 ,  B01D15/32 ,  B01D15/34 ,  B01J19/00 ,  G01N30/02 ,  G01N30/20 ,  G01N30/32 ,  G01N30/46 ,  G01N30/86 ,  G01N33/44 ,  G01N30/88

CPC classification number: G01N30/463 ,  B01D15/1878 ,  B01D15/265 ,  B01D15/325 ,  B01D15/34 ,  B01D15/424 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00286 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00389 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00704 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B01J2219/00736 ,  G01N30/02 ,  G01N30/20 ,  G01N30/46 ,  G01N30/461 ,  G01N30/8651 ,  G01N33/44 ,  G01N2030/027 ,  G01N2030/324 ,  G01N30/16

Abstract: Methods and apparatus for characterizing a polymer sample and in preferred embodiments, libraries of polymer samples, in a comprehensive, directly-coupled multi-dimensional liquid chromatography system are disclosed. The first and second dimensions are preferably high-performance liquid chromatography dimensions, such as for example, a first dimension adapted for determining composition e.g. adapted for mobile-phase gradient elution chromatography, including reverse phase chromatography, adsorption chromatography and the like), and a second dimension adapted for determining molecular weight or particle size (e.g., adapted for size exclusion chromatography, including gel permeation chromatography).

Abstract translation: 公开了在综合的直接耦合的多维液相色谱系统中用于表征聚合物样品的方法和装置，并且在优选实施方案中，聚合物样品的文库。 第一和第二维度优选是高效液相色谱尺寸，例如，适于确定组合物的第一维度。 适用于流动相梯度洗脱色谱法，包括反相色谱法，吸附色谱法等），以及适用于测定分子量或粒度的第二维度（例如适用于尺寸排阻色谱法，包括凝胶渗透色谱法）。