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    Method and apparatus for the rapid disruption of cells or viruses using micro magnetic beads and laser
    1.
    发明公开
    Method and apparatus for the rapid disruption of cells or viruses using micro magnetic beads and laser 有权
    一种用于细胞和病毒的通过使用微磁珠和激光的快速中断的方法和装置

    公开(公告)号：EP1650297A2

    公开(公告)日：2006-04-26

    申请号：EP05022672.9

    申请日：2005-10-18

    Applicant: Samsung Electronics Co., Ltd.

    Inventor： Lee, Jeong-gun ,  Kwon, Young-nam ,  Kim, Young-a 245-1804 Hwanggol Maeul Ssangyong Apt ,  Lee, Myo-yong ,  Yoo, Shin-i ,  Cho, Yeon-ja ,  Cheong, Kwang-ho ,  Yoo, Chang-eun ,  Yang, Seung-yeon,904-1704 Cheongsol Maeul

    IPC: C12N13/00 ,  B01L3/00

    CPC classification number: C12M47/06 ,  B01F11/0266 ,  B01F13/0059 ,  B01L3/502761 ,  B01L2300/0816 ,  C12N1/066 ,  C12N13/00

    Abstract: A method and apparatus for a rapid disruption of cells or viruses using micro magnetic beads and a laser are provided. According to the method and apparatus for a rapid disruption of cells or viruses using micro magnetic beads and a laser, cell lysis within 40 seconds is possible, the apparatus can be miniaturized using a laser diode, a DNA purification step can be directly performed after a disruption of cells or viruses, and a solution containing DNA can be transferred to a subsequent step after cell debris and beads to which inhibitors of a subsequent reaction are attached are removed with an electromagnet. In addition, by means of the cell lysis chip, an evaporation problem is solved, vibrations can be efficiently transferred to cells through magnetic beads, a microfluidics problem on a rough surface is solved by hydrophobically treating the inner surface of the chip, and the cell lysis chip can be applied to LOC.

    Abstract translation: 提供了一种用于利用微磁珠和激光细胞或病毒的快速中断的方法和装置。 。根据用于使用微磁珠和激光，细胞裂解细胞或病毒的快速破坏的方法和装置，在40秒内是可能的，该装置可以使用激光二极管的小型化中，DNA的纯化步骤可以直接后一演出 细胞或病毒，和溶液含有DNA的破坏可以被转移到到所连接的后续反应的抑制剂在电磁体与被去除细胞碎片和颗粒之后的后续步骤。 此外，通过细胞裂解芯片蒸发麻烦的手段解决，振动可以有效地通过磁珠转移到细胞中，在粗糙表面上的微流体麻烦是由疏水处理的芯片的内表面来解决，并且细胞 裂解芯片可应用于LOC。

    Method of detecting bio-molecules using field effect transistor without fixing bio-molecules on the gate sensing surface
    6.
    发明公开
    Method of detecting bio-molecules using field effect transistor without fixing bio-molecules on the gate sensing surface 有权
    用于经由场效应晶体管过程中测量表面上的生物分子检测生物分子不固定方法

    公开(公告)号：EP1843157A1

    公开(公告)日：2007-10-10

    申请号：EP07104460.6

    申请日：2007-03-20

    Applicant: Samsung Electronics Co., Ltd.

    Inventor： Yoo, Kyu-tae ,  Lee, Kyu-sang ,  Chung, Won-seok ,  Shim, Jeo-young ,  Cho, Yeon-ja

    IPC: G01N33/543

    CPC classification number: G01N33/54373

    Abstract: Provided is a method of detecting the presence of bio-molecules or a concentration of target bio-molecules using a field effect transistor without fixing bio-molecules on a sensing surface. The field effect transistor includes: a semiconductor substrate; a source region and a drain region which are formed to be separate on the substrate and doped to have the opposite polarity to the substrate; a channel region disposed between the source region and the drain region; an insulating layer having the sensing surface which is disposed on the channel region and composed of an electrically insulating material; and a reference electrode disposed above and separate from the insulating layer. The method includes providing a first sample having a first target bio-molecule to a sensing surface of the field effect transistor and measuring a change in electric signal of the field effect transistor.

    Abstract translation: 本发明提供一种检测有机分子的存在或使用场效应晶体管，而不上的感测表面固定的生物分子目标的生物分子的浓度的方法。 该场效应晶体管包括：半导体基片; 一个源极区和其上形成为在基片上分离且掺杂为具有相反的极性于基板的漏极区; 源区和漏区之间设置的沟道区; 在绝缘具有感测表面的所有其被设置在沟道区和电绝缘材料组成的层; 和参比电极的正上方，并从绝缘层分开。 该方法包括提供具有第一靶生物分子与所述场效应晶体管的传感表面并测量场效应晶体管的电信号变化的第一样本。

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