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    Multi-channel fluorescence measuring optical system and multi-channel fluorescence sample analyzer
    3.
    发明公开
    Multi-channel fluorescence measuring optical system and multi-channel fluorescence sample analyzer 审中-公开
    Optisches Mehrkanal-Fluoreszenzmesssystem und Mehrkanal-Fluoreszenz probenanysator

    公开(公告)号：EP1688734A1

    公开(公告)日：2006-08-09

    申请号：EP06000070.0

    申请日：2006-01-03

    Applicant: Samsung Electronics Co., Ltd.

    Inventor： Ok, Gyeong-sik ,  Kim, Su-hyeon ,  Kim, Jin-tae ,  Oh, Kwang-wook

    IPC: G01N21/64 ,  G01N21/05 ,  G01J3/44 ,  C12M1/34 ,  C12Q1/68

    CPC classification number: G01J3/10 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/4406 ,  G01J2003/1213 ,  G01N21/05 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/0346 ,  G01N2021/3174 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0221 ,  G01N2201/0407 ,  G01N2201/0461 ,  G01N2201/0612 ,  G01N2201/0627 ,  G01N2201/0631 ,  G01N2201/0806 ,  G01N2201/0833

    Abstract: A multi-channel fluorescence measuring optical system and a multi-channel fluorescence sample analyzer using the optical system are provided. The multi-channel fluorescence measuring optical system, which irradiates light onto a plurality of sample channels and detecting fluorescence radiated from samples (m), includes: a light source (10); an integrator (20) for giving the light irradiated from the light source a uniform intensity distribution; a sample holder (30) having a plurality of sample channels on which the samples (m) are mounted, wherein the samples (m) are exited by the light emitted from the integrator (20); a beam splitter (25) between the integrator (20) and the sample holder (30) for dividing the incident light in a predetermined ratio; and a light detecting unit (40) for detecting fluorescence from the samples (m) through the beam splitter (25). Preferably, the light intensities of fluorescence images are detected using optical fiber bundles and photodiodes, the manufacturing cost can be greatly reduced, and the optical system can be miniaturized.

    Abstract translation: 提供多通道荧光测量光学系统和使用该光学系统的多通道荧光样品分析仪。 将光照射到多个样品通道上并检测从样品（m）辐射的荧光的多通道荧光测量光学系统包括：光源（10）; 用于给从光源照射的光均匀的强度分布的积分器（20）; 具有安装有样品（m）的多个样品通道的样品保持器（30），其中所述样品（m）由所述积分器（20）发射的光退出; 在积分器（20）和样品保持器（30）之间的分光器（25），用于以预定比例对入射光进行分光; 以及用于通过分束器（25）检测来自样品（m）的荧光的光检测单元（40）。 优选地，使用光纤束和光电二极管检测荧光图像的光强度，可以大大降低制造成本，并且可以使光学系统小型化。

    Method of Reducing Temperature Difference Between a Pair of Substrates and Fluid Reaction Device Using the Same
    5.
    发明公开
    Method of Reducing Temperature Difference Between a Pair of Substrates and Fluid Reaction Device Using the Same 审中-公开
    减少两个衬底之间的温度差的方法，和使用该流体反应装置

    公开(公告)号：EP1894884A1

    公开(公告)日：2008-03-05

    申请号：EP07104705.4

    申请日：2007-03-22

    Applicant: Samsung Electronics Co., Ltd.

    Inventor： Namkoong, Kak ,  Kim, Su-hyeon ,  Kim, Jin-tae ,  Park, Chin-sung ,  Lee, Young-sun

    IPC: B81B3/00

    CPC classification number: B81B3/0081 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00873 ,  B01L3/5027 ,  B01L7/5255 ,  B01L2200/14 ,  B01L2200/147 ,  B01L2300/1805 ,  B01L2300/1827 ,  B81B2201/051 ,  F28F21/02 ,  F28F2013/006

    Abstract: Provided is a method of reducing the temperature difference between a pair of substrates (103, 121), which are a high-temperature substrate (103) and a low-temperature substrate (121), including a heat transfer facilitating layer (110) which has a higher thermal conductivity than air and can hold particles (150) between those substrates (103, 121), and maintaining close contacts among the high-temperature substrate (103), the heat transfer facilitating layer (110), and the low-temperature substrate (121) so that the formation of an air layer can be prevented both between the high-temperature substrate (103) and the heat transfer facilitating layer (110), and between the low-temperature substrate (121) and the heat transfer facilitating layer (110). In addition, provided is a fluid reaction device (100) comprising: a microfluidic reaction chip (120) that accommodates a fluid (F); a heater (101) that heats the microfluidic reaction chip (120); and a heat transfer facilitating layer (110) that is interposed between the microfluidic reaction chip (120) and the heater (101), has a higher thermal conductivity than air and can hold particles (150), wherein the heater (101), the heat transfer facilitating layer (110), and the microfluidic reaction chip (120) are fixed to one another so that the formation of an air layer can be prevented both between the heater (101) and the heat transfer facilitating layer (110), and between the microfluidic reaction chip (120) and the heat transfer facilitating layer (110).

    Abstract translation: 提供了减少的一对衬底之间的温度差（103，121），这是一个高温的基材（103）和一个低温衬底（121），其包括传热促进层（110）的方法，其 具有比空气更高的导热性，并且可以保持这些基片（103，121），和维护高温基板（103）之间的密切接触，传热促进层（110），并且所述低之间的颗粒（150） 温度的基板（121），以便做了一个空气层的形成，可以防止两者高温基板（103）和所述传热促进层（110）之间以及在低温衬底（121）和所述传热之间 促进层（110）。 此外，提供了一种流体反应装置（100），包括：（120）做了微流控反应芯片容纳的流体（F）; 加热器（101）加热做微流体反应芯片（120）; 和传热促进层（110），其被所述微流体反应芯片（120）和所述加热器（101）之间插入具有比空气更高的导热性，并且可以保持粒子（150），其中，所述加热器（101），所述 传热促进层（110），并且所述微流体反应芯片（120）被固定到彼此所以没有空气层的形成，可以防止两者的加热器（101）和所述传热促进层（110）之间，并且 微流体反应芯片（120）和所述传热促进层（110）之间。

    Fluorescence detector for detecting microfluid
    7.
    发明公开
    Fluorescence detector for detecting microfluid 有权
    系统umfassend einen Fluoreszenznachweissystem und einen Mikrofluidchip mit einer Mikrokammer

    公开(公告)号：EP1550858A1

    公开(公告)日：2005-07-06

    申请号：EP04020439.8

    申请日：2004-08-27

    Applicant: Samsung Electronics Co., Ltd.

    Inventor： Kim, Su-hyeon ,  Kim, Jin-tae

    IPC: G01N21/64

    CPC classification number: G01N21/645 ,  G01N2021/6482

    Abstract: An ultra small fluorescence detector capable of detecting in real time reaction undergoing in a micro chamber having a predetermined volume and disposed on a microfluid chip is provided. The fluorescence detector for detecting in real time PCR amplification undergoing in the microfluid chip having a micro chamber with a predetermined volume includes a light source generating an excitation beam, a first optical system capable of irradiating the excitation beam having a predetermined spot size to the micro chamber, a first detector, and a second optical system reflecting a fluorescent beam derived from the excitation beam having the predetermined spot size in the micro chamber to the first detector. Accordingly, the fluorescence detector is designed such that light emitted by a light source is focused between a first mirror and an objective lens. Therefore, the spot size of an excitation beam transmitted by the objective lens is largely formed so that the excitation beam can be irradiated on the whole micro chamber of the microfluid chip, thereby detecting a fluorescent beam on a broader area.

    Abstract translation: 提供了能够实时检测在具有预定体积的微室中进行反应并设置在微流体芯片上的超小荧光检测器。 用于实时检测在具有预定体积的微室的微流体芯片中进行PCR扩增的荧光检测器包括产生激发光束的光源，能够将具有预定光斑尺寸的激发光束照射到微细的第一光学系统 室，第一检测器和第二光学系统，其将来自具有在微室中的预定光斑尺寸的激发光束的荧光束反射到第一检测器。 因此，荧光检测器被设计成使得由光源发射的光聚焦在第一反射镜和物镜之间。 因此，由物镜透射的激发光束的光斑尺寸大部分形成为使得激发光束能够照射在微流体芯片的整个微室上，从而在更广泛的区域上检测荧光束。

    Optical system for analyzing multi-channel samples and multi-channel sample analyzer employing same
    10.
    发明公开
    Optical system for analyzing multi-channel samples and multi-channel sample analyzer employing same 审中-公开
    用于分析的多通道采样和多通道试样分析装置的光学系统

    公开(公告)号：EP1637873A3

    公开(公告)日：2007-08-22

    申请号：EP05020023.7

    申请日：2005-09-14

    Applicant: Samsung Electronics Co., Ltd.

    Inventor： Ok, Gyeong-sik ,  Cho, Yoon-kyoung ,  Kim, Jin-tae ,  Oh, Kwang-wook

    IPC: G01N21/64

    CPC classification number: G01N21/645

    Abstract: Provided are an optical system for analyzing multi-channel samples which uses a mirror rotating at high speeds and an aspherical mirror, and a multi-channel sample analyzer employing the optical system. The optical system for analyzing multi-channel samples, includes a light source unit which emits light traveling along an optical axis; a semi-spheroid aspherical mirror disposed in rotational symmetry about the optical axis; and an inclined mirror which reflects the light exiting the light source unit to the semi-spheroid aspherical mirror, while rotating about the optical axis, wherein an opening is formed in the center of the semi-spheroid aspherical mirror such that the light exiting the light source unit enters the inclined mirror through the semi-spheroid aspherical mirror.

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