公开(公告)号：US20030086968A1

公开(公告)日：2003-05-08

申请号：US10256518

申请日：2002-09-26

Applicant: SEPRACOR INC.

Inventor： Nancy M. Gray

IPC: A61K031/4439

CPC classification number: A61K31/4439 ,  A61K31/44

Abstract: Methods and compositions are disclosed utilizing optically pure (null) pantoprazole for the treatment of ulcers in humans while substantially reducing the concomitant liability of adverse effects associated with the racemic mixture of pantoprazole. The optically pure (null) isomer is also useful for the treatment of gastroesophageal reflux. (null) Pantoprazole is an inhibitor of Hnull release and is therefore useful in the treatment of other conditions related to gastric hypersecretion such as Zollinger-Ellison Syndrome.

Abstract translation: 公开了使用光学纯的（ - ）泮托拉唑用于治疗人类溃疡的方法和组合物，同时显着降低与泮托拉唑的外消旋混合物相关的副作用的伴随的责任。 光学纯的（ - ）异构体也可用于治疗胃食管反流。 （ - ）泮托拉唑是H +释放的抑制剂，因此可用于治疗与胃分泌异常有关的其他病症，如Zollinger-Ellison综合征。

公开(公告)号：US20020019420A1

公开(公告)日：2002-02-14

申请号：US09948983

申请日：2001-09-07

Applicant: Sepracor Inc.

Inventor： Nancy M. Gray

IPC: A61K031/4439

CPC classification number: A61K31/44

Abstract: Methods and compositions are disclosed utilizing optically pure (null) pantoprazole for the treatment of ulcers in humans while substantially reducing the concomitant liability of adverse effects associated with the racemic mixture of pantoprazole. The optically pure (null) isomer is also useful for the treatment of gastroesophageal reflux. (null) Pantoprazole is an inhibitor of Hnull release and is therefore useful in the treatment of other conditions related to gastric hypersecretion such as Zollinger-Ellison Syndrome.

Abstract translation: 公开了使用光学纯的（+）泮托拉唑用于治疗人体溃疡的方法和组合物，同时显着降低与泮托拉唑的外消旋混合物相关的副作用的伴随的责任。 光学纯的（+）异构体也可用于治疗胃食管反流。 （+）泮托拉唑是H +释放的抑制剂，因此可用于治疗与胃分泌异常有关的其他病症，如Zollinger-Ellison综合征。