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公开(公告)号：US20170291044A1
公开(公告)日：2017-10-12
申请号：US15630623
申请日：2017-06-22
Inventor： Hairong ZHENG , Lili NIU , Congzhi WANG , Ming QIAN , Yang XIAO , Long MENG
CPC classification number: A61N7/02 , A61B5/0042 , A61B5/04001 , A61B5/0484 , A61B5/055 , A61B5/4836 , A61B5/7239 , A61B2562/0209 , A61B2562/046 , A61N2007/0026 , A61N2007/0052 , A61N2007/0073 , A61N2007/0082 , G16H50/50
Abstract: An ultrasound deep brain stimulation method and system, the ultrasound deep brain stimulation method comprises: medically imaging a head of an animal or a human being, to generate image data; creating a head 3D digital model according to the image data; creating a 3D digital model of an ultrasound transducer array according to structure, density and acoustic parameters information of the ultrasound transducer array; generating a first ultrasound transmitting sequence according to the head 3D digital model, the 3D digital model of the ultrasound transducer array, structure, density and acoustic parameters of the skull and brain tissues, and structure, density and acoustic parameters of the ultrasound transducer array; and controlling the ultrasound transducer array to transmit ultrasound waves in accordance with the first ultrasound transmitting sequence, to implement ultrasound deep brain stimulation to the brain nucleus to be stimulated. By the use of the present invention, ultrasound can noninvasively passes through the skull to be focused in a deep brain region. By the use of different ultrasound transmitting sequences, ultrasound neuromodulation can be realized, and research on an action mechanism for the ultrasound neuromodulation can be performed.
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公开(公告)号：US20210308676A1
公开(公告)日：2021-10-07
申请号：US16769103
申请日：2018-12-21
Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY
Inventor： Hairong ZHENG , Fei LI , Feiyan CAI , Long MENG , Yang XIAO , Fei YAN
Abstract: A microfluidic system, including: a container, an ultrasound transmitter assembly, and a phononic crystal plate. The container is configured to accommodate a solution containing microparticles. The ultrasound transmitter assembly is configured to transmit ultrasonic waves to the phononic crystal plate, where the ultrasonic waves have a frequency which is the same as a resonance frequency of the phononic crystal plate. The phononic crystal plate is placed in the solution, and configured to generate a local acoustic field on a surface of the phononic crystal plate under excitation of the ultrasonic waves, and induce an acoustic microstreaming vortex to generate an acoustic streaming shear stress on the microparticles. The phononic crystal plate defines therein cavities, the respective cavities are arranged periodically in the phononic crystal plate, and all the respective cavities are filled with gas.
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3.发明申请公开(公告)号：US20200229794A1
公开(公告)日：2020-07-23
申请号：US16482802
申请日：2017-12-26
Applicant: Shenzhen Institutes of Advanced Technology
Inventor： Yang XIAO , Hairong ZHENG , Congzhi WANG , Lili NIU , Zhiting DENG
IPC: A61B8/08
Abstract: A method and a device for acquiring biomechanical parameters based on an ultrasonic elastomyogram are provided, wherein the method includes: synchronously collecting a dynamic myodynamics image sequence and a dynamic elasticity image sequence of a single skeletal muscle under continuous stretching; acquiring a myodynamics parameter corresponding to each myodynamics image in the dynamic myodynamics image sequence and an elasticity modulus value corresponding to each elasticity image in the dynamic elasticity image sequence respectively; and generating an ultrasonic elastomyogram curve with the myodynamics parameter as the abscissa and the synchronized elasticity modulus value as the ordinate, and estimating a muscle biomechanical parameter based on the ultrasonic elastomyogram curve. Dynamically changing biomechanical parameters can be obtained, and the obtained muscle biomechanical parameters have relatively high accuracy.
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