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    1-disubstituted aminopyrazoles
    2.
    发明授权
    1-disubstituted aminopyrazoles 失效
    1-取代的氨基吡唑

    公开(公告)号：US3694456A

    公开(公告)日：1972-09-26

    申请号：US3694456D

    申请日：1970-05-08

    Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

    Inventor： NOGUCHI SHUNSAKU ,  KISHIMOTO SHOJI ,  KAWAI KIYOHISA

    IPC: C07D231/12 ,  C07D49/20

    CPC classification number: C07D231/12 ,  Y10S514/906 ,  Y10S514/916

    Abstract: 1-(Disubstituted-amino)pyrazole compounds are provided herein of the formula: WHEREIN EACH OF R1 and R2 stands for lower alkyl or R1 and R2, taken together with the adjacent N-atom form morpholino, piperidino, pyrrolidino, N-methylpiperazino, N-benzylpiperazino and N-phenylpiperazino, R''s, which are the same or different from each other, stand for hydrogen, alkyl having one to ten carbon atoms, phenyl, naphthyl, phenyl or naphthyl substituted by halogen or lower alkyl, respectively, and R3 stands for hydrogen, lower alkyl, N,N-di-loweralkylaminoethyl, N-morpholinomethyl, Npiperidinomethyl, N-pyrrolidinomethyl, N-methylpiperazinomethyl, N-benzylpiperazinomethyl and N-phenylpiperazinomethyl. The above compounds as well as the pharmaceutically acceptable salts thereof are useful as analgesics, antipyretics and mild muscle relaxants.

    Abstract translation: 本文提供下式的1-（二取代 - 氨基）吡唑化合物：

    TETRAPEPTIDE DERIVATIVE
    6.
    发明专利
    TETRAPEPTIDE DERIVATIVE 失效

    公开(公告)号：JPS55118444A

    公开(公告)日：1980-09-11

    申请号：JP2686479

    申请日：1979-03-07

    Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

    Inventor： FUJINO MASAHIKO ,  SHINAGAWA SUSUMU ,  KAWAI KIYOHISA

    IPC: C07K5/10 ,  A61K38/00 ,  A61P25/04 ,  C07K1/06 ,  C07K14/575 ,  C07K14/655

    Abstract: NEW MATERIAL:Tetrapeptide derivatives of formula I (R1 and R2 are H, methy; R3 is H, hydroxyl, lower alkoxy, lower thioalkyl, lower thioalkyloxide, halogen or lower aliphatic acyl that may be substituted with oxo) and their acid adducts. EXAMPLE:H-Tyr-(D)-met(O)-Gly-Phe-NH-NH-CO-CH2CH3. USE:Analgesic and a remedy for gastrointsetinal disorders, e.g., diarrhea, because they have activity of inhibiting gastrointestinal movement. PREPARATION:The protecting groups are removed from the compound of formula II (R3' is R3 that may have a protecting group; Y1 is protecting group; Y2 and Y3 are H, protecting group) to give the compound of formula I.

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