公开(公告)号：US10947198B2

公开(公告)日：2021-03-16

申请号：US16549337

申请日：2019-08-23

Applicant: THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY

Inventor： Kenneth Darrell Berlin ,  Richard A. Bunce ,  Krishna Kumar Gnanasekaran ,  Field M. Watts, Jr. ,  Donghua Howard Zhou

IPC: C07D215/06 ,  A61P35/00 ,  C07D335/06 ,  C07D311/70

Abstract: Chemical compounds that inhibit cancer cell growth are provided. The compounds are heteroarotinoids and derivatives thereof with oxygen, nitrogen or sulfur in chroman systems, tetrahydroquinoline systems, and tetrahydrothiochroman systems.

公开(公告)号：US12263156B2

公开(公告)日：2025-04-01

申请号：US17502975

申请日：2021-10-15

Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College ,  University of Kansas ,  The Board of Regents for Oklahoma State University

Inventor： Mario Rivera ,  Huili Yao ,  Richard A. Bunce ,  Baskar Nammalwar ,  Krishna Kumar Gnanasekaran ,  Kate Eshelman ,  Achala N. D. Punchi Hewage ,  Scott Lovell ,  Anabel Soldano

IPC: A61P31/04 ,  A61K31/4035

Abstract: The present invention discloses methods of inhibiting biofilm formation, increasing bacteriocidal activity within a biofilm, treating bacteria within a biofilm, or remediating a biofilm in or on a subject, comprising administering to the subject an effective amount of a compound according to Formula I: wherein R1-5 are defined herein.

公开(公告)号：US12251370B2

公开(公告)日：2025-03-18

申请号：US17299267

申请日：2019-12-03

Applicant: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE ,  UNIVERSITY OF KANSAS ,  THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY

Inventor： Mario Rivera ,  Huili Yao ,  Richard A. Bunce ,  Baskar Nammalwar ,  Krishna Kumar Gnanasekaran ,  Kate Eshelman ,  Achala N. D. Punchi Hewage ,  Scott Lovell

IPC: A61K31/4035 ,  A61K31/454 ,  A61K31/496 ,  A61K31/502 ,  A61P31/04 ,  C07D209/48 ,  C07D237/32 ,  C07D401/12 ,  C07D405/12

Abstract: The present technology provides compounds of Formula I and related methods for treating a bacterial infection as well as methods for inhibiting interaction of a bacterioferritin and a bacterioferritin-associated ferredoxin.

公开(公告)号：US11993573B2

公开(公告)日：2024-05-28

申请号：US17167251

申请日：2021-02-04

Applicant: THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY

Inventor： Kenneth Darrell Berlin ,  Richard A. Bunce ,  Krishna Kumar Gnanasekaran ,  Field M. Watts, Jr. ,  Donghua Howard Zhou

IPC: A61P35/00 ,  A61K31/352 ,  A61K31/382 ,  A61K31/47 ,  C07D215/06 ,  C07D311/70 ,  C07D335/06

CPC classification number: C07D215/06 ,  A61K31/352 ,  A61K31/382 ,  A61K31/47 ,  A61P35/00 ,  C07D311/70 ,  C07D335/06

Abstract: Chemical compounds that inhibit cancer cell growth are provided. The compounds are heteroarotinoids and derivatives thereof with oxygen, nitrogen or sulfur in chroman systems, tetrahydroquinoline systems, and tetrahydrothiochroman systems.