公开(公告)号：US20190381503A1

公开(公告)日：2019-12-19

申请号：US16441577

申请日：2019-06-14

Applicant: The Charles Stark Draper Laboratory, Inc.

Inventor： Hongmei Zhang ,  Melissa Sprachman ,  Parshant Kumar ,  Parker Dow ,  Heena Mutha

IPC: B01L3/00 ,  G01N33/543

Abstract: The present disclosure describes a systems and methods to rapidly detect a level of a drug present in a fluid sample. The systems and methods can be used to monitor drug levels in the blood of a patient to whom the drug has been prescribed. A system can include one or more organic electrochemical transistors that are functionalized with a coating that may include aptamers or antibodies. The coating can bind or otherwise interact with the drug of interest to change the transconductance of the organic electrochemical transistors. The system can detect a change in the transconductance of the organic electrochemical transistors and signal the presence of the drug.

公开(公告)号：US11385400B2

公开(公告)日：2022-07-12

申请号：US15811203

申请日：2017-11-13

Applicant: The Charles Stark Draper Laboratory, Inc.

Inventor： Jesse J. Wheeler ,  Joseph J. Register ,  Parshant Kumar ,  Carlos A. Segura ,  Charles A. Lissandrello ,  John J. LeBlanc

IPC: G02B6/02 ,  A61B5/00 ,  G02B6/12 ,  A61N5/06 ,  B05D1/00 ,  B05D3/10 ,  B05D3/12 ,  G02B1/04 ,  G02B6/26

Abstract: The material stack of the present disclosure can be used for fabricating optical waveguides that are thin and flexible, and that can bend light around small turns. The stack of materials can include a polymer core and a cladding, which together can create a large difference in refractive index. As a result, light can remain within the core even when bent around radii where standard glass fibers could fail.

公开(公告)号：US20180136389A1

公开(公告)日：2018-05-17

申请号：US15811203

申请日：2017-11-13

Applicant: The Charles Stark Draper Laboratory, Inc.

Inventor： Jesse J. Wheeler ,  Joseph J. Register ,  Parshant Kumar ,  Carlos A. Segura ,  Charles A. Lissandrello ,  John J. LeBlanc

IPC: G02B6/02 ,  G02B1/04 ,  G02B6/26 ,  B05D1/00 ,  B05D3/10 ,  B05D3/12 ,  A61N5/06

CPC classification number: G02B6/02033 ,  A61B5/6846 ,  A61N5/0601 ,  A61N2005/0612 ,  B05D1/005 ,  B05D3/107 ,  B05D3/12 ,  G02B1/046 ,  G02B1/048 ,  G02B6/12 ,  G02B6/262 ,  G02B2006/12069 ,  G02B2006/12138

Abstract: The material stack of the present disclosure can be used for fabricating optical waveguides that are thin and flexible, and that can bend light around small turns. The stack of materials can include a polymer core and a cladding, which together can create a large difference in refractive index. As a result, light can remain within the core even when bent around radii where standard glass fibers could fail.

公开(公告)号：US20170367418A1

公开(公告)日：2017-12-28

申请号：US15534907

申请日：2015-12-09

Applicant: THE CHARLES STARK DRAPER LABORATORY, INC.

Inventor： David J. Carter ,  Tirunelveli S. Sriram ,  Parshant Kumar ,  Clayton Morris ,  William W. McFarland ,  Eugene H. Cook ,  John LeBlanc ,  Alla Gimbel

IPC: A41D19/015 ,  B29C33/42 ,  B29D99/00 ,  B29C33/38 ,  B29C39/10 ,  B29C45/37 ,  B29C39/02 ,  B29L31/48

CPC classification number: A41D19/01564 ,  B29C33/3842 ,  B29C33/424 ,  B29C33/58 ,  B29C37/0053 ,  B29C39/026 ,  B29C39/10 ,  B29C39/26 ,  B29C45/372 ,  B29C2059/023 ,  B29D99/0067 ,  B29K2075/00 ,  B29K2105/0097 ,  B29K2863/00 ,  B29K2891/00 ,  B29L2031/4864

Abstract: A mold for casting a micro-scale structure includes an upper surface including a first cavity having a first depth. A negative pattern for an array of micro-scale structures is defined in a surface of the first cavity. The mold includes at least one second cavity having a second depth defined in the cavity outside of the negative pattern for the array of micro-scale structures. The at least one second cavity defines a negative pattern for a standoff of the micro-scale structure. A fabric retaining frame is disposed in the first cavity.

公开(公告)号：US12059575B2

公开(公告)日：2024-08-13

申请号：US15811429

申请日：2017-11-13

Applicant: The Charles Stark Draper Laboratory, Inc.

Inventor： Jesse J. Wheeler ,  Joseph J. Register ,  Parshant Kumar ,  Carlos A. Segura ,  Charles A. Lissandrello ,  John J. LeBlanc

IPC: A61N5/06 ,  A61B5/00

CPC classification number: A61N5/0622 ,  A61B5/0031 ,  A61N5/0601 ,  A61N2005/0612 ,  A61N2005/063

Abstract: A device can include a first compliant optrode. The first compliant optrode can be introduced into a tissue sample and can include a stack of flexible waveguide materials providing a first optical interface. The stack of flexible waveguide materials can have a thickness of less than about 100 microns. The first compliant optrode can be linear and can be configured to bend at a turn radius of less than about 300 microns.

公开(公告)号：US20180133506A1

公开(公告)日：2018-05-17

申请号：US15811429

申请日：2017-11-13

Applicant: The Charles Stark Draper Laboratory, Inc.

Inventor： Jesse J. Wheeler ,  Joseph J. Register ,  Parshant Kumar ,  Carlos A. Segura ,  Charles A. Lissandrello ,  John J. LeBlanc

IPC: A61N5/06 ,  A61B5/00

CPC classification number: A61N5/0622 ,  A61B5/0031 ,  A61N5/0601 ,  A61N2005/0612 ,  A61N2005/063

Abstract: This disclosure provides a device that can include a first compliant optrode. The first compliant optrode can include a stack of flexible waveguide materials providing a first optical interface and configured to be introduced into a tissue sample. The stack of flexible waveguide materials can have a thickness of less than about 100 microns. The first compliant optrode can be substantially linear and can be configured to bend at a turn radius of less than about 300 microns.

公开(公告)号：US10791779B2

公开(公告)日：2020-10-06

申请号：US15534907

申请日：2015-12-09

Applicant: THE CHARLES STARK DRAPER LABORATORY, INC.

Inventor： David J. Carter ,  Tirunelveli S. Sriram ,  Parshant Kumar ,  Clayton Morris ,  William W. McFarland ,  Eugene H. Cook ,  John LeBlanc ,  Alla Gimbel

IPC: A41D19/015 ,  B29C45/37 ,  B29C33/42 ,  B29C37/00 ,  B29C39/02 ,  B29C39/10 ,  B29D99/00 ,  B29C33/38 ,  B29C33/58 ,  B29C39/26 ,  B29L31/48 ,  B29C59/02 ,  B29K75/00 ,  B29K105/00

Abstract: A mold for casting a micro-scale structure includes an upper surface including a first cavity having a first depth. A negative pattern for an array of micro-scale structures is defined in a surface of the first cavity. The mold includes at least one second cavity having a second depth defined in the cavity outside of the negative pattern for the array of micro-scale structures. The at least one second cavity defines a negative pattern for a standoff of the micro-scale structure. A fabric retaining frame is disposed in the first cavity.

公开(公告)号：US20180264687A1

公开(公告)日：2018-09-20

申请号：US15534918

申请日：2015-12-09

Applicant: David J. CARTER ,  Tirunelveli S. SRIRAM ,  Parshant KUMAR ,  Clayton MORRIS ,  William W. MCFARLAND ,  Eugene H. COOK ,  John LE BLANC ,  Alla EPSHTEYN ,  W. Dennis SLAFER ,  B. Diane MARTIN ,  THE CHARLES STARK DRAPER LABORATORY, INC. ,  MICROCONTINUUM, INC.

Inventor： David J. Carter ,  Tirunelveli S. Sriram ,  Parshant Kumar ,  Clayton Morris ,  William W. McFarland ,  Eugene H. Cook ,  John LeBlanc ,  Alla Epshteyn ,  W. Dennis Slafer ,  B. Diane Martin

IPC: B29C33/30 ,  B29C33/38 ,  B29C33/42 ,  B29C33/68 ,  B29C39/02 ,  C25D1/10 ,  C25D5/34

CPC classification number: B29C33/307 ,  B23P15/00 ,  B23P15/24 ,  B29C33/3842 ,  B29C33/42 ,  B29C33/424 ,  B29C33/68 ,  B29C39/026 ,  B29K2905/00 ,  B81C99/0085 ,  C25D1/00 ,  C25D1/10 ,  C25D1/22 ,  C25D5/34

Abstract: A method of forming a metal mold for casting a micro-scale dry adhesive structure includes securing a master patch of material including a micro-scale dry adhesive structure on a plating fixture, electroforming the metal mold on the patch of material, and removing the metal mold from the plating fixture and patch of material.

公开(公告)号：US20170361508A1

公开(公告)日：2017-12-21

申请号：US15534827

申请日：2015-12-09

Applicant: THE CHARLES STARK DRAPER LABORATORY, INC.

Inventor： David J. Carter ,  Tirunelveli S. Sriram ,  Parshant Kumar ,  Clayton Morris ,  William W. McFarland ,  Eugene H. Cook ,  John LeBlanc ,  Alla Gimbel

IPC: B29C39/26 ,  B29C37/00 ,  B29C33/38 ,  B29C33/58 ,  B29C39/02 ,  B29K75/00 ,  B29K105/00 ,  B29L31/48

CPC classification number: A41D19/01564 ,  B29C33/3842 ,  B29C33/424 ,  B29C33/58 ,  B29C37/0053 ,  B29C39/026 ,  B29C39/10 ,  B29C39/26 ,  B29C45/372 ,  B29C2059/023 ,  B29D99/0067 ,  B29K2075/00 ,  B29K2105/0097 ,  B29K2863/00 ,  B29K2891/00 ,  B29L2031/4864

Abstract: A mold for casting a micro-scale dry adhesive structure includes an upper surface including a first cavity having a first depth, a negative pattern for an array of micro-scale structures defined in a surface of the first cavity, and at least one second cavity having a second depth defined in the cavity outside of the negative pattern for the array of micro-scale structures, the at least one second cavity defining a negative pattern for a standoff of the micro-scale dry adhesive structure.