公开(公告)号：EP0413068A1

公开(公告)日：1991-02-20

申请号：EP89308419.4

申请日：1989-08-18

Applicant: THE STANDARD OIL COMPANY

Inventor： Burrington, James D. ,  Cesa, Mark C. ,  Dubbert, Robert A.

IPC: C07C227/32 ,  C07C231/18

CPC classification number: C07C227/32 ,  C07C231/00 ,  C07C231/18 ,  C07C237/00 ,  C07C319/28 ,  C07C323/58 ,  C07C2601/14 ,  C07D207/16 ,  C07D209/16 ,  C07D233/54 ,  C07D233/64

Abstract: In the process of hydrocarboxylating an α-enamide with CO and H₂O or an organic hydroxyl compound to produce an N-acyl-α-amino acid or ester, respectively, the improvement comprising using as the α-enamide reactant, an α-enamide which has a chiral center that is essentially all L or D, thereby producing a reaction mixture containing diastereomeric N-acyl-α-amino acids or esters having two chiral centers, said mixture having essentially no enantiomeric pairs.

Abstract translation: 在阿尔法-enamide与CO和H 2 O或者有机羟基化合物的hydrocarboxylating以产生N-酰基的α氨基酸或酯的过程中，分别使用改进作为阿尔法-enamide反应物包括与α--enamide哪 具有手性中心，其基本上所有L或D，从而产生反应混合物含有具有两个手性中心的非对映的N-酰基 - α氨基酸或酯，所述的基本上无混合物对映体对。

公开(公告)号：EP0482732B1

公开(公告)日：1995-02-01

申请号：EP91302208.3

申请日：1991-03-14

Applicant: THE STANDARD OIL COMPANY

Inventor： Cesa, Mark C. ,  Dubbert, Robert A.

IPC: C07C209/48

CPC classification number: C07C209/48

公开(公告)号：EP0315716B1

公开(公告)日：1992-09-02

申请号：EP87309927.9

申请日：1987-11-10

Applicant: THE STANDARD OIL COMPANY

Inventor： Cesa, Mark C. ,  Burrington, James D. ,  Dubbert, Robert A.

IPC: C07C231/00 ,  C07C233/45 ,  C07C323/00 ,  C07D233/64 ,  C07D209/20

CPC classification number: C07C51/14 ,  C07B2200/07 ,  C07C67/38 ,  C07C231/00 ,  C07C237/00 ,  C07C59/08 ,  C07C53/08

公开(公告)号：EP0315716A1

公开(公告)日：1989-05-17

申请号：EP87309927.9

申请日：1987-11-10

Applicant: THE STANDARD OIL COMPANY

Inventor： Cesa, Mark C. ,  Burrington, James D. ,  Dubbert, Robert A.

IPC: C07C231/00 ,  C07C233/45 ,  C07C323/00 ,  C07D233/64 ,  C07D209/20

CPC classification number: C07C51/14 ,  C07B2200/07 ,  C07C67/38 ,  C07C231/00 ,  C07C237/00 ,  C07C59/08 ,  C07C53/08

Abstract: In the process of hydrocarboxylating an α-enamide with CO and an organic hydroxyl compound to produce a N-acyl-α-amino acid ester, the improvement comprising using as the organic hydroxyl compound reactant, an organic hydroxyl compound which has a chiral center that is essentially all L or D, thereby producing a reaction mixture having essentially no enantiomeric pairs and containing diastereomeric N-acyl-α-amino acid esters having two chiral centers.

Abstract translation: 在用CO和有机羟基化合物加氢羧化α-烯酰胺以制备N-酰基-α-氨基酸酯的过程中，改进包括使用具有手性中心的有机羟基化合物作为有机羟基化合物反应物， 基本上都是L或D，从而产生基本上没有对映体对并含有具有两个手性中心的非对映体N-酰基-α-氨基酸酯的反应混合物。

公开(公告)号：EP1077080A1

公开(公告)日：2001-02-21

申请号：EP99306525.9

申请日：1999-08-18

Applicant: The Standard Oil Company

Inventor： Attig, Thomas G. ,  Dubbert, Robert A. ,  Budge, John R.

IPC: B01J23/68 ,  B01J23/89 ,  C07D307/08 ,  C07C29/17

CPC classification number: C07D307/08 ,  B01J21/18 ,  B01J23/688 ,  B01J23/8986 ,  B01J37/0207 ,  C07C29/177 ,  C12C11/02 ,  C07C31/207

Abstract: An improved catalyst for hydrogenation of maleic acid, maleic anhydride or other hydrogenatable precursor which are catalytically hydrogenated to 1,4-butanediol and tetrahydrofuran has been discovered. The hydrogenation catalyst comprises palladium, silver, rhenium and at lease one of aluminum, cobalt and mixtures thereof, all on a carbon support.

Abstract translation: 已经发现了用于氢化马来酸，马来酸酐或其它可氢化前体的改进的催化剂，其被催化氢化成1,4-丁二醇和四氢呋喃。 氢化催化剂包括钯，银，铼和至少一种铝，钴及其混合物，全部在碳载体上。

公开(公告)号：EP0482732A1

公开(公告)日：1992-04-29

申请号：EP91302208.3

申请日：1991-03-14

Applicant: THE STANDARD OIL COMPANY

Inventor： Cesa, Mark C. ,  Dubbert, Robert A.

IPC: C07C209/48

CPC classification number: C07C209/48

Abstract: Disclosed is a process for making ethylamines by the hydrogenation in a reaction zone of acetonitrile contained in a basic aqueous solution which also contains HCN, which comprises continuously passing hydrogen gas in contact with a flowing steam containing acetonitrile, water and HCN, which stream is in contact with a solid hydrogenation catalyst, wherein the hydrogen contact time is in the range from 0.5 seconds to 20 minutes and the molar ratio of H 2 to acetonitrile charged to said reaction zone is in the range 2-200:1.

Abstract translation: 公开了一种通过在含有HCN的碱性水溶液中所含的乙腈的反应区中氢化制备乙胺的方法，该方法包括使含有连续通过氢气与含有乙腈，水和HCN的流动蒸汽接触， 与固体氢化催化剂接触，其中氢接触时间在0.5秒至20分钟的范围内，并且加入到所述反应区的H 2与乙腈的摩尔比在2-200:1的范围内。