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    MICROARRAY IMAGING SYSTEM AND ASSOCIATED METHODOLOGY
    1.
    发明申请
    MICROARRAY IMAGING SYSTEM AND ASSOCIATED METHODOLOGY 审中-公开
    微型成像系统及相关方法

    公开(公告)号：WO2007104057A3

    公开(公告)日：2008-04-24

    申请号：PCT/US2007063721

    申请日：2007-03-09

    Applicant: TIBBETTS CLARK

    Inventor： TIBBETTS CLARK

    IPC: G01J1/20

    CPC classification number: G01J3/02 ,  G01J3/0229 ,  G01J3/10 ,  G01J3/2846 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2201/0626 ,  G01N2201/0631

    Abstract: An apparatus and method are provided for creating an image of a microarray. The apparatus includes at least one light source configured to direct light toward the microarray. The apparatus includes an excitation filter configured to filter the light into a first frequency band towards dichromatic mirror. The dichromatic mirror reflects light onto the microarray causing the microarray to emit electromagnetic energy. The apparatus includes emission filter configured to filter the electromagnetic energy within a second frequency band. The apparatus further includes an imaging unit having a charged coupled device (CCD), the CC having an Imaging surface masked by a pinhole blind such that when the pinhole blind receives electromagnetic energy from the emission filter, an image is created of the entire microarray.

    Abstract translation: 提供了一种用于创建微阵列图像的装置和方法。 该装置包括被配置为将光引向微阵列的至少一个光源。 该装置包括被配置为将光过滤到朝向二色镜的第一频带的激励滤波器。 二色镜将光反射到微阵列上，导致微阵列发射电磁能。 该装置包括被配置为过滤第二频带内的电磁能的发射滤波器。 所述装置还包括具有电荷耦合器件（CCD）的成像单元，所述CC具有由针孔盲孔掩蔽的成像表面，使得当针孔盲孔从发射滤光片接收电磁能时，产生整个微阵列的图像。

    APPARATUS AND METHODS FOR APPLICATIONS OF GENOMIC MICROARRAYS IN SCREENING, SURVEILLANCE AND DIAGNOSTICS
    3.
    发明申请
    APPARATUS AND METHODS FOR APPLICATIONS OF GENOMIC MICROARRAYS IN SCREENING, SURVEILLANCE AND DIAGNOSTICS 审中-公开
    在筛选，监测和诊断中应用基因组微阵列的装置和方法

    公开(公告)号：WO2007104052A3

    公开(公告)日：2008-10-30

    申请号：PCT/US2007063697

    申请日：2007-03-09

    Applicant: TIBBETTS CLARK

    Inventor： TIBBETTS CLARK

    IPC: C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  C12M1/00 ,  C12M1/34 ,  C12M3/00

    CPC classification number: C12Q1/6809 ,  C12Q1/6806 ,  C12Q1/6837 ,  C12Q2565/501

    Abstract: This disclosure describes combinations of apparatus and methods to comprise a system for broad use and effective application of analytical genomic microarrays for screening and surveillance. The methodology abandons reliance on typical volumes of peripheral blood samples obtained by phlebotomy, in preference for protocols enabling collection, stabilization, archive, extraction and purification of small volumes as obtained from a finger prick. Recommended processing protocols from such starting material favor preparation of sufficient quantities of RNA or DNA of sufficient quality for subsequent steps of targeted amplification and fluorescent labeling. A strategy is offered for effective integration of capabilities for genotype and phenotype analysis on the same microarray layout. These gene expression re-sequencing arrays (GXR) are well suited for screening and surveillance applications.

    Abstract translation: 本公开描述了包括用于筛选和监测的分析基因组微阵列的广泛使用和有效应用的系统的装置和方法的组合。 该方法放弃依赖于通过静脉切开术获得的外周血样品的典型体积，优于通过手指刺取获得的能够收集，稳定，归档，提取和纯化小体积的方案。 这种起始物质的推荐加工方案有利于制备足够质量的足够量的RNA或DNA，以便后续步骤进行靶向扩增和荧光标记。 提供了一种策略，用于在相同的微阵列布局上有效地整合基因型和表型分析的能力。 这些基因表达重排序阵列（GXR）非常适合筛选和监测应用。

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