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    SUSTAINED RELEASE PREPARATION OF HYDROGENATED ERGOT-ALKALOID AND ITS PREPARATION
    1.
    发明专利
    SUSTAINED RELEASE PREPARATION OF HYDROGENATED ERGOT-ALKALOID AND ITS PREPARATION 失效

    公开(公告)号：JPS615010A

    公开(公告)日：1986-01-10

    申请号：JP12379784

    申请日：1984-06-18

    Applicant: TOA EIYO LTD

    Inventor： NARA TAKESHI ,  NISHINOMIYA YOUZOU ,  HAYASHI HISASHI ,  ISHIDA TADAO

    IPC: A61K31/48 ,  A61K9/00 ,  A61K9/62 ,  A61K47/36

    Abstract: PURPOSE:The titled pharmaceutical preparation capable of keeping blood concentration without damaging biological utility, obtained by coating nucleated particles of water-soluble additional matter of drug with a water-soluble gel high polymer film containing a hydrogenated ergot-alkaloid and a film consisting of an enteric base. CONSTITUTION:The surface of nucleated particles obtained by granulating a water-soluble additional matter of drug (e.g., lactose, or mannitol) is sprayed with a solution of a hydrogenated ergot-alkaloid (e.g., dihydroergotoxine) and a water-soluble gel high polymer such as hydroxypropyl cellulose, hydroxypropylmethyl cellylose, etc. in a blending ratio (weight ratio) of the former to the latter of 1:1-20, preferably 1:2-10 in an organic solvent, and it is dried. The prepared film is coated with a film of coating consisting of an enteric base (e.g., hydroxypropylmethyl cellulose phthalate) and/or ethyl cellulose, or coated in the opposite order, to give the aimed sustained release preparation.

    STABLE ISOSORBIDE NITRATE COMPOSITION AND ITS PREPARATION
    3.
    发明专利
    STABLE ISOSORBIDE NITRATE COMPOSITION AND ITS PREPARATION 失效

    公开(公告)号：JPS60181052A

    公开(公告)日：1985-09-14

    申请号：JP3618084

    申请日：1984-02-29

    Applicant: TOA EIYO LTD

    Inventor： NARA TAKESHI ,  HAYASHI HISASHI ,  SATOU KENTAROU

    IPC: C07C201/02 ,  C07C67/00 ,  C07C201/00 ,  C07C201/16 ,  C07C203/02 ,  C07C203/04

    Abstract: PURPOSE:To provide the titled composition having high stability and handleability, free from irritation and volatility, and effective as a remedy and preventive for the fit of stenocardia, by compounding isosorbide nitrate with a specific component such as polyvinyl pyrrolidone. CONSTITUTION:Isosorbide nitrate is compounded with one or more components selected from the group of polyvinyl pyrrolidone, methyl-cellulose, hydroxypropylcellulose and hydroxypropylmethylcellulose. The amount of the latter component is 0.2-30pts.wt., especially 1-15pts.wt. per 1pt.wt. of isosorbide nitrate. The composition is prepared preferably by dissolving isosorbide nitrate in a solvent, and then dissolving and/or dispersing the latter component such as polyvinyl pyrrolidone in the solution, however, it may be prepared by mixing the solution or dispersion of isosorbide nitrate with the of the latter component.

    STABLE HUMAN ANGIOTENSIN AGENT
    7.
    发明专利
    STABLE HUMAN ANGIOTENSIN AGENT 失效

    公开(公告)号：JPS6219531A

    公开(公告)日：1987-01-28

    申请号：JP15594885

    申请日：1985-07-17

    Applicant: TOA EIYO LTD

    Inventor： NARA TAKESHI ,  NISHINOMIYA YOZO ,  SATOU KENTAROU ,  HAYASHI HISASHI

    IPC: A61K38/00 ,  A61K47/00 ,  A61K47/12 ,  A61K47/18 ,  A61K47/36 ,  A61K47/42

    Abstract: PURPOSE:To provide the titled drug preparation containing human-type angiotensin in combination with a specific stabilizing agent and useful as a hypertensive agent. CONSTITUTION:The objective human-type angiotensin agent contains (A) human- type angiotensin and (B) one or more stabilizers selected from gelatin, albumin, acidic polysaccharide (e.g. chondroitin sulfate, dextran sulfate, heparin, etc.), acidic amino acid (e.g. glutamic acid, aspartic acid, etc.) and organic acid (e.g. citric acid, lactic acid, tartaric acid, malic acid, etc.). The amounts of gelatin and albumin are preferably 1-1,000pts.wt., and the amounts of the other components are 1-500pts.wt. each per 1pt.wt. of angiotensin. EFFECT:Since the decomposition of angiotensin in the dissolved solution is suppressed and the stability of angiotensin is improved remarkably, the agent is convenient for production, treatment and storage.

    SUSTAINED RELEASE PHARMACEUTICAL OF SLIGHTLY SOLUBLE DRUG AND PRODUCTION THEREOF
    8.
    发明专利
    SUSTAINED RELEASE PHARMACEUTICAL OF SLIGHTLY SOLUBLE DRUG AND PRODUCTION THEREOF 失效

    公开(公告)号：JPS61148115A

    公开(公告)日：1986-07-05

    申请号：JP26859284

    申请日：1984-12-21

    Applicant: TOA EIYO LTD

    Inventor： NARA TAKESHI ,  HATORI TOKUO ,  NISHINOMIYA YOZO ,  HAYASHI HISASHI

    IPC: A61K9/16 ,  A61K9/20 ,  A61K9/22 ,  A61K31/34 ,  A61K31/505 ,  A61P9/12

    Abstract: PURPOSE:The titled pharmaceutical of a slightly soluble drug consisting of the slightly soluble drug, a release inhibitor and high swelling polymer. CONSTITUTION:A sustained release pharmaceutical containing a slightly soluble drug, e.g. isosorbid nitrate, prazosin hydrochloride or furosemide, 5-80wt% release inhibitor, e.g. ethyl cellulose, acrylic acid-methacrylic ester copolymer, hardened oil or wax and 0.5-20wt% swelling high polymer, e.g. carboxyvinyl polymer, hydroxypropyl cellulose with a low substitution degree or microcrystalline cellulose. The resultant pharmaceutical has a little change in release rate due to variation in size of granular material, method of preparation, hardness of compression molded material, etc., and therefore excellent reproducibility of release rate renders the pharmaceutical suitable for mass production. The slightly soluble drug is released for a long time by given combination of the above-mentioned respective materials, and the dissolution rate of the slightly soluble drug shows a safe dissolution of about 100%.

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