公开(公告)号：JPH0246020B2

公开(公告)日：1990-10-12

申请号：JP20026882

申请日：1982-11-17

Applicant: TOA EIYO LTD

Inventor： NARA TAKESHI ,  NISHINOMYA YOZO ,  SATO KENTARO ,  KAMIKAMA KANEHITO

IPC: C08B37/16 ,  A61K47/40 ,  C07C67/00 ,  C07C201/00 ,  C07C201/02 ,  C07C201/16 ,  C07C203/02 ,  C07C203/04

公开(公告)号：JPS5993032A

公开(公告)日：1984-05-29

申请号：JP20026882

申请日：1982-11-17

Applicant: TOA EIYO LTD

Inventor： NARA TAKESHI ,  NISHINOMIYA YOUZOU ,  SATOU KENTAROU ,  KAMIKAMA KANEHITO

IPC: C08B37/16 ,  A61K47/40 ,  C07C67/00 ,  C07C201/00 ,  C07C201/02 ,  C07C201/16 ,  C07C203/02 ,  C07C203/04

Abstract: PURPOSE:The titled stable and easily handleable inclusion compound useful as a drug, capable of relieving irritation and preventing volatility, having high safety for tableting, molding, etc., obtained by including an isosorbidnitrate with cyclodextrin. CONSTITUTION:An isosorbidnitrate having a coronary blood vasodilating action, a dinitro ester or mononitro ester derivative of isosorbidnitrate widely used as a remedy and preventive for attack of angine pectoris in the form of a sublingual tablet, oral drug, sustained release drug, injection, etc., is dissolved or dispersed into a solvent containing preferably an equimolar amount of cyclodextrin and water, and the solvent is eliminated to give an isosorbidnitrate- cyclodextrin inclusion compound. alpha-, beta- and gamma-cyclodextrin, a cyclic oligosaccharide called cycloamylose, etc., comprising 6-8 constitutional units of D- glucopyranoses is used as the cyclodextrin.