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公开(公告)号：GR3032681T3
公开(公告)日：2000-06-30
申请号：GR20000400379
申请日：2000-02-16
Applicant: TORAY INDUSTRIES
Inventor： SUGAYA HIROYUKI , MINAGA MASAHIRO , TERADA RYOZO , TAYAMA TOSHIKAZU , TANAKA KAZUMI , FUKUI FUMIAKI
IPC: B01D67/00 , B01D71/28 , B01D71/40 , C08F283/06 , C08F290/06 , C08F299/02 , A61M1/16
Abstract: A hydrophilic material comprising a copolymer composed of a monomer (A) having a polyalkylene oxide unit and a polymerizable carbon-carbon double bond in its molecule, a methacrylate or acrylate monomer (B) and another monomer (C) having a polymerizable carbon-carbon double bond in its molecule, which material is characterized by containing the monomer (C) in the proportion of 10 to 90 % by weight. The invention provides a hydrophilic material which is soluble, readily moldable, and excellent in antithrombotic and antifouling properties, and further provides an antithrombotic material and a semipermeable membrane. These materials can be appropriately used in the medical field and as water-absorbent and antifouling materials.
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公开(公告)号：DE69327578T2
公开(公告)日：2000-08-24
申请号：DE69327578
申请日：1993-09-28
Applicant: TORAY INDUSTRIES
Inventor： SUGAYA HIROYUKI , MINAGA MASAHIRO , TERADA RYOZO , TAYAMA TOSHIKAZU , TANAKA KAZUMI , FUKUI FUMIAKI
IPC: B01D67/00 , B01D71/28 , B01D71/40 , C08F283/06 , C08F290/06 , C08F299/02 , A61M1/16 , C08F220/28 , C08F212/14 , A61L33/00
Abstract: A hydrophilic material comprising a copolymer composed of a monomer (A) having a polyalkylene oxide unit and a polymerizable carbon-carbon double bond in its molecule, a methacrylate or acrylate monomer (B) and another monomer (C) having a polymerizable carbon-carbon double bond in its molecule, which material is characterized by containing the monomer (C) in the proportion of 10 to 90 % by weight. The invention provides a hydrophilic material which is soluble, readily moldable, and excellent in antithrombotic and antifouling properties, and further provides an antithrombotic material and a semipermeable membrane. These materials can be appropriately used in the medical field and as water-absorbent and antifouling materials.
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3.发明专利
公开(公告)号：ES2237760T3
公开(公告)日：2005-08-01
申请号：ES96304796
申请日：1996-06-28
Applicant: TORAY INDUSTRIES
Inventor： SHIMAGAKI MASAAKI , FUKUI FUMIAKI , SONODA TAKESHI , SUGITA KOJI
Abstract: LAS MEMBRANAS DE FIBRA HUECA RESPECTIVAS APROPIADAS PARA USAR EN LA ELIMINACION DE CONTAMINANTES NO DESEADOS DE LA SANGRE, EN PARTICULAR EN UN RIÑON ARTIFICIAL, TIENEN: (1) AREA POR MEMBRANA DE 1.6 M{SUP,2}, UN ESPACIO IN VITRO PARA UREA Y FOSFORO RESPECTIVAMENTE DE (MAYOR O IGUAL) 195, Y (MAYOR O IGUAL) 180, ML/MIN, UN ESPACIO {BE}{SUB,2}-MICROGLOBULINA DE (MAYOR O IGUAL) 44 ML/MIN Y PERMEABILIDAD DE ALBUMINA DE (MENOR O IGUAL) 0,5%; (2) UNA PERMEABILIDAD DE ALBUMINA DE (MENOR O IGUAL) 1,5% Y UN COEFICIENTE TOTAL DE MASA TRANSFERIBLE DE K{SUB,O} (MAYOR O IGUAL) 0,0012 CM/MIN; Y (3) UN DIALIZANTE DE VITAMINA B{SUB,12} DE (MAYOR O IGUAL) 135 ML/MIN Y UNA PERMEABILIDAD DE ALBUMINA DE (MENOR O IGUAL) 3%. LAS MEMBRANAS PUEDEN SER PREPARADAS MEDIANTE GIRO DE FIBRA HUECA DE UNA SOLUCION DE GIRO QUE CONTIENE UNA POLISULFONA, UN POLIMERO HIDROFILO , UN DISOLVENTE Y AGUA, TENIENDO LA SOLUCION DE GIRO UNA VISCOSIDAD X A 30 (GRADOS) C DE 25-130 DE EQUILIBRIO Y UNA CANTIDAD Y% DE AGUA DADO POR: -0,01X+ 1,45 (MENOR O IGUAL) -0,01X + 2,25 LAS MEMBRANAS PUEDEN SER INCORPORADAS A UN MODULO HEMODIALIZADOR POR UN METODO EN EL QUE SON PREIMPREGNADAS CON UN AGENTE HUMECTANTE, Y A PARTIR DE ENTONCES GUARDADAS SEPARADAMENTE LA UNA DE LA OTRA POR ESPACIADORES Y ENTONCES INSERTADAS EN EL MODULO.
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公开(公告)号：ES2140468T3
公开(公告)日：2000-03-01
申请号：ES93921075
申请日：1993-09-28
Applicant: TORAY INDUSTRIES
Inventor： SUGAYA HIROYUKI , MINAGA MASAHIRO , TERADA RYOZO , TAYAMA TOSHIKAZU , TANAKA KAZUMI , FUKUI FUMIAKI
IPC: B01D67/00 , B01D71/28 , B01D71/40 , C08F283/06 , C08F290/06 , C08F299/02 , A61M1/16 , C08F220/28 , C08F212/14 , A61L33/00
Abstract: A hydrophilic material comprising a copolymer composed of a monomer (A) having a polyalkylene oxide unit and a polymerizable carbon-carbon double bond in its molecule, a methacrylate or acrylate monomer (B) and another monomer (C) having a polymerizable carbon-carbon double bond in its molecule, which material is characterized by containing the monomer (C) in the proportion of 10 to 90 % by weight. The invention provides a hydrophilic material which is soluble, readily moldable, and excellent in antithrombotic and antifouling properties, and further provides an antithrombotic material and a semipermeable membrane. These materials can be appropriately used in the medical field and as water-absorbent and antifouling materials.
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公开(公告)号：CA2124579A1
公开(公告)日：1994-04-14
申请号：CA2124579
申请日：1993-09-28
Applicant: TORAY INDUSTRIES
Inventor： SUGAYA HIROYUKI , MINAGA MASAHIRO , TERADA RYOZO , TAYAMA TOSHIKAZU , TANAKA KAZUMI , FUKUI FUMIAKI
IPC: B01D67/00 , B01D71/28 , B01D71/40 , C08F283/06 , C08F290/06 , C08F299/02 , A61L33/00 , B01D71/26
Abstract: Disclosed is a hydrophilic material characterized in that the material comprises a copolymer composed of a monomer (A) having a polyalkylene oxide unit and a polymerizable carboncarbon double bond in its molecule, a methacrylic ester monomer or an acrylic ester monomer (B) and a monomer (C) having a polymerizable carbon-carbon double bond other than the monomers (A) and (B), and the content of the monomer (C) is not less than 5% by weight and not more than 90% by weight, and a semipermeable membrane made therefrom. The present invention provides a hydrophilic material which can be dissolved in a solvent, can be easily formed and is excellent in antithrombotic and antifouling properties, and further provides an antithrombotic material and a semipermeable membrane. These materials can be appropriately used in the medical field and as water-absorbent and antifouling materials. - 4 6
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Patent Agency Ranking
公开(公告)号：AT289219T
公开(公告)日：2005-03-15
申请号：AT96304796
申请日：1996-06-28
Applicant: TORAY INDUSTRIES
Inventor： SHIMAGAKI MASAAKI , FUKUI FUMIAKI , SONODA TAKESHI , SUGITA KOJI
Abstract: Respective hollow fiber membranes suitable for use in removing undesired contaminants from blood, in particular in an artificial kidney, have: (1) per membrane area of 1.6 m , in vitro clearances for urea and phosphorus respectively of ≥ 195, and ≥ 180, ml/min, a beta 2-microglobulin clearance ≥ 44 ml/min and an albumin permeability ≤ 0.5%; (2) an albumin permeability ≤ 1.5% and an overall mass transfer coefficient Ko ≥ 0.0012 cm/min; and (3) a vitamin B12 dialyzance of ≥ 135 ml/min and an albumin permeability ≤ 3%. The membranes can be prepared by spinning hollow fibers from a spinning solution comprising a polysulfone, a hydrophilic polymer, a solvent and water, the spinning solution having a viscosity x at 30 DEG C of 25-130 poise and a quantity y % of water given by: The membranes can be incorporated into a hemodialyzer module by a method in which they are preimpregnated with a wetting agent, thereafter kept separate from one another by spacers and then inserted in the module.
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公开(公告)号：AT188714T
公开(公告)日：2000-01-15
申请号：AT93921075
申请日：1993-09-28
Applicant: TORAY INDUSTRIES
Inventor： SUGAYA HIROYUKI , MINAGA MASAHIRO , TERADA RYOZO , TAYAMA TOSHIKAZU , TANAKA KAZUMI , FUKUI FUMIAKI
IPC: B01D67/00 , B01D71/28 , B01D71/40 , C08F283/06 , C08F290/06 , C08F299/02 , A61M1/16 , C08F220/28 , C08F212/14 , A61L33/00
Abstract: A hydrophilic material comprising a copolymer composed of a monomer (A) having a polyalkylene oxide unit and a polymerizable carbon-carbon double bond in its molecule, a methacrylate or acrylate monomer (B) and another monomer (C) having a polymerizable carbon-carbon double bond in its molecule, which material is characterized by containing the monomer (C) in the proportion of 10 to 90 % by weight. The invention provides a hydrophilic material which is soluble, readily moldable, and excellent in antithrombotic and antifouling properties, and further provides an antithrombotic material and a semipermeable membrane. These materials can be appropriately used in the medical field and as water-absorbent and antifouling materials.
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公开(公告)号：CA2180222A1
公开(公告)日：1996-12-31
申请号：CA2180222
申请日：1996-06-28
Applicant: TORAY INDUSTRIES
Inventor： SHIMAGAKI MASAAKI , FUKUI FUMIAKI , SONODA TAKESHI , SUGITA KOJI
Abstract: Respective hollow fiber membranes suitable for use in removing undesired contaminants from blood, in particular in an artificial kidney have: (1) per membrane area of 1.6 m2, in vitro clearances for urea and phosphorus respectively of ml/min, a .beta.2-microglobulin clearance albumin permeability (2) an albumin permeability mass transfer coefficient Ko (3) a vitamin B12 dialyzance of albumin permeability The membranes can be prepared by spinning hollow fibers from a spinning solution comprising a polysulfone, a hydrophilic polymer, a solvent and water, the spinning solution having a viscosity x at 30.degree.C of 25-130 poise and a quantity y % of water given by: -0.01x + 1.45 The membranes can be incorporated into a hemodialyzer module by a method in which they are preimpregnated with a wetting agent, thereafter kept separate from one another by spacers and then inserted in the module.
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公开(公告)号：CA2180222C
公开(公告)日：2006-10-10
申请号：CA2180222
申请日：1996-06-28
Applicant: TORAY INDUSTRIES
Inventor： SHIMAGAKI MASAAKI , FUKUI FUMIAKI , SONODA TAKESHI , SUGITA KOJI
Abstract: Respective hollow fiber membranes suitable for use in removing undesired contaminants from blood, in particular in an artificial kidney, have: (1) per membrane area of 1.6 m2, in vitro clearances for urea and phosphorus respectively of .gtoreq. 195, and .gtoreq. 180, ml/min, a .beta.2-microglobulin clearance .gtoreq. 44 ml/min and an albumin permeability .ltoreq. 0.5%; (2) an albumin permeability .ltoreq. 1.5% and an overall mass transfer coefficient Ko .gtoreq. 0.0012 cm/min; and (3) a vitamin B12 dialyzance of .gtoreq. 135 ml/min and an albumin permeability .ltoreq. 3%. The membranes can be prepared by spinning hollow fibers from a spinning solution comprising a polysulfone, a hydrophilic polymer, a solvent and water, the spinning solution having a viscosity x at 30.degree.C of 25-130 poise and a quantity y % of water given by: -0.01.times. + 1.45 .ltoreq. y .ltoreq. -0.01.times. + 2.25. The membranes can be incorporated into a hemodialyzer module by a method in which they are preimpregnated with a wetting agent, thereafter kept separate from one another by spacers and then inserted in the module.
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公开(公告)号：DE69634352T2
公开(公告)日：2006-01-12
申请号：DE69634352
申请日：1996-06-28
Applicant: TORAY INDUSTRIES
Inventor： SHIMAGAKI MASAAKI , FUKUI FUMIAKI , SONODA TAKESHI , SUGITA KOJI
Abstract: Respective hollow fiber membranes suitable for use in removing undesired contaminants from blood, in particular in an artificial kidney, have: (1) per membrane area of 1.6 m , in vitro clearances for urea and phosphorus respectively of ≥ 195, and ≥ 180, ml/min, a beta 2-microglobulin clearance ≥ 44 ml/min and an albumin permeability ≤ 0.5%; (2) an albumin permeability ≤ 1.5% and an overall mass transfer coefficient Ko ≥ 0.0012 cm/min; and (3) a vitamin B12 dialyzance of ≥ 135 ml/min and an albumin permeability ≤ 3%. The membranes can be prepared by spinning hollow fibers from a spinning solution comprising a polysulfone, a hydrophilic polymer, a solvent and water, the spinning solution having a viscosity x at 30 DEG C of 25-130 poise and a quantity y % of water given by: The membranes can be incorporated into a hemodialyzer module by a method in which they are preimpregnated with a wetting agent, thereafter kept separate from one another by spacers and then inserted in the module.
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