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1.发明专利
公开(公告)号：ES2237760T3
公开(公告)日：2005-08-01
申请号：ES96304796
申请日：1996-06-28
Applicant: TORAY INDUSTRIES
Inventor： SHIMAGAKI MASAAKI , FUKUI FUMIAKI , SONODA TAKESHI , SUGITA KOJI
Abstract: LAS MEMBRANAS DE FIBRA HUECA RESPECTIVAS APROPIADAS PARA USAR EN LA ELIMINACION DE CONTAMINANTES NO DESEADOS DE LA SANGRE, EN PARTICULAR EN UN RIÑON ARTIFICIAL, TIENEN: (1) AREA POR MEMBRANA DE 1.6 M{SUP,2}, UN ESPACIO IN VITRO PARA UREA Y FOSFORO RESPECTIVAMENTE DE (MAYOR O IGUAL) 195, Y (MAYOR O IGUAL) 180, ML/MIN, UN ESPACIO {BE}{SUB,2}-MICROGLOBULINA DE (MAYOR O IGUAL) 44 ML/MIN Y PERMEABILIDAD DE ALBUMINA DE (MENOR O IGUAL) 0,5%; (2) UNA PERMEABILIDAD DE ALBUMINA DE (MENOR O IGUAL) 1,5% Y UN COEFICIENTE TOTAL DE MASA TRANSFERIBLE DE K{SUB,O} (MAYOR O IGUAL) 0,0012 CM/MIN; Y (3) UN DIALIZANTE DE VITAMINA B{SUB,12} DE (MAYOR O IGUAL) 135 ML/MIN Y UNA PERMEABILIDAD DE ALBUMINA DE (MENOR O IGUAL) 3%. LAS MEMBRANAS PUEDEN SER PREPARADAS MEDIANTE GIRO DE FIBRA HUECA DE UNA SOLUCION DE GIRO QUE CONTIENE UNA POLISULFONA, UN POLIMERO HIDROFILO , UN DISOLVENTE Y AGUA, TENIENDO LA SOLUCION DE GIRO UNA VISCOSIDAD X A 30 (GRADOS) C DE 25-130 DE EQUILIBRIO Y UNA CANTIDAD Y% DE AGUA DADO POR: -0,01X+ 1,45 (MENOR O IGUAL) -0,01X + 2,25 LAS MEMBRANAS PUEDEN SER INCORPORADAS A UN MODULO HEMODIALIZADOR POR UN METODO EN EL QUE SON PREIMPREGNADAS CON UN AGENTE HUMECTANTE, Y A PARTIR DE ENTONCES GUARDADAS SEPARADAMENTE LA UNA DE LA OTRA POR ESPACIADORES Y ENTONCES INSERTADAS EN EL MODULO.
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公开(公告)号：AT289219T
公开(公告)日：2005-03-15
申请号：AT96304796
申请日：1996-06-28
Applicant: TORAY INDUSTRIES
Inventor： SHIMAGAKI MASAAKI , FUKUI FUMIAKI , SONODA TAKESHI , SUGITA KOJI
Abstract: Respective hollow fiber membranes suitable for use in removing undesired contaminants from blood, in particular in an artificial kidney, have: (1) per membrane area of 1.6 m , in vitro clearances for urea and phosphorus respectively of ≥ 195, and ≥ 180, ml/min, a beta 2-microglobulin clearance ≥ 44 ml/min and an albumin permeability ≤ 0.5%; (2) an albumin permeability ≤ 1.5% and an overall mass transfer coefficient Ko ≥ 0.0012 cm/min; and (3) a vitamin B12 dialyzance of ≥ 135 ml/min and an albumin permeability ≤ 3%. The membranes can be prepared by spinning hollow fibers from a spinning solution comprising a polysulfone, a hydrophilic polymer, a solvent and water, the spinning solution having a viscosity x at 30 DEG C of 25-130 poise and a quantity y % of water given by: The membranes can be incorporated into a hemodialyzer module by a method in which they are preimpregnated with a wetting agent, thereafter kept separate from one another by spacers and then inserted in the module.
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公开(公告)号：CA2180222A1
公开(公告)日：1996-12-31
申请号：CA2180222
申请日：1996-06-28
Applicant: TORAY INDUSTRIES
Inventor： SHIMAGAKI MASAAKI , FUKUI FUMIAKI , SONODA TAKESHI , SUGITA KOJI
Abstract: Respective hollow fiber membranes suitable for use in removing undesired contaminants from blood, in particular in an artificial kidney have: (1) per membrane area of 1.6 m2, in vitro clearances for urea and phosphorus respectively of ml/min, a .beta.2-microglobulin clearance albumin permeability (2) an albumin permeability mass transfer coefficient Ko (3) a vitamin B12 dialyzance of albumin permeability The membranes can be prepared by spinning hollow fibers from a spinning solution comprising a polysulfone, a hydrophilic polymer, a solvent and water, the spinning solution having a viscosity x at 30.degree.C of 25-130 poise and a quantity y % of water given by: -0.01x + 1.45 The membranes can be incorporated into a hemodialyzer module by a method in which they are preimpregnated with a wetting agent, thereafter kept separate from one another by spacers and then inserted in the module.
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公开(公告)号：CA2180222C
公开(公告)日：2006-10-10
申请号：CA2180222
申请日：1996-06-28
Applicant: TORAY INDUSTRIES
Inventor： SHIMAGAKI MASAAKI , FUKUI FUMIAKI , SONODA TAKESHI , SUGITA KOJI
Abstract: Respective hollow fiber membranes suitable for use in removing undesired contaminants from blood, in particular in an artificial kidney, have: (1) per membrane area of 1.6 m2, in vitro clearances for urea and phosphorus respectively of .gtoreq. 195, and .gtoreq. 180, ml/min, a .beta.2-microglobulin clearance .gtoreq. 44 ml/min and an albumin permeability .ltoreq. 0.5%; (2) an albumin permeability .ltoreq. 1.5% and an overall mass transfer coefficient Ko .gtoreq. 0.0012 cm/min; and (3) a vitamin B12 dialyzance of .gtoreq. 135 ml/min and an albumin permeability .ltoreq. 3%. The membranes can be prepared by spinning hollow fibers from a spinning solution comprising a polysulfone, a hydrophilic polymer, a solvent and water, the spinning solution having a viscosity x at 30.degree.C of 25-130 poise and a quantity y % of water given by: -0.01.times. + 1.45 .ltoreq. y .ltoreq. -0.01.times. + 2.25. The membranes can be incorporated into a hemodialyzer module by a method in which they are preimpregnated with a wetting agent, thereafter kept separate from one another by spacers and then inserted in the module.
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公开(公告)号：DE69634352T2
公开(公告)日：2006-01-12
申请号：DE69634352
申请日：1996-06-28
Applicant: TORAY INDUSTRIES
Inventor： SHIMAGAKI MASAAKI , FUKUI FUMIAKI , SONODA TAKESHI , SUGITA KOJI
Abstract: Respective hollow fiber membranes suitable for use in removing undesired contaminants from blood, in particular in an artificial kidney, have: (1) per membrane area of 1.6 m , in vitro clearances for urea and phosphorus respectively of ≥ 195, and ≥ 180, ml/min, a beta 2-microglobulin clearance ≥ 44 ml/min and an albumin permeability ≤ 0.5%; (2) an albumin permeability ≤ 1.5% and an overall mass transfer coefficient Ko ≥ 0.0012 cm/min; and (3) a vitamin B12 dialyzance of ≥ 135 ml/min and an albumin permeability ≤ 3%. The membranes can be prepared by spinning hollow fibers from a spinning solution comprising a polysulfone, a hydrophilic polymer, a solvent and water, the spinning solution having a viscosity x at 30 DEG C of 25-130 poise and a quantity y % of water given by: The membranes can be incorporated into a hemodialyzer module by a method in which they are preimpregnated with a wetting agent, thereafter kept separate from one another by spacers and then inserted in the module.
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Patent Agency Ranking
公开(公告)号：DE69634352D1
公开(公告)日：2005-03-24
申请号：DE69634352
申请日：1996-06-28
Applicant: TORAY INDUSTRIES
Inventor： SHIMAGAKI MASAAKI , FUKUI FUMIAKI , SONODA TAKESHI , SUGITA KOJI
Abstract: Respective hollow fiber membranes suitable for use in removing undesired contaminants from blood, in particular in an artificial kidney, have: (1) per membrane area of 1.6 m , in vitro clearances for urea and phosphorus respectively of ≥ 195, and ≥ 180, ml/min, a beta 2-microglobulin clearance ≥ 44 ml/min and an albumin permeability ≤ 0.5%; (2) an albumin permeability ≤ 1.5% and an overall mass transfer coefficient Ko ≥ 0.0012 cm/min; and (3) a vitamin B12 dialyzance of ≥ 135 ml/min and an albumin permeability ≤ 3%. The membranes can be prepared by spinning hollow fibers from a spinning solution comprising a polysulfone, a hydrophilic polymer, a solvent and water, the spinning solution having a viscosity x at 30 DEG C of 25-130 poise and a quantity y % of water given by: The membranes can be incorporated into a hemodialyzer module by a method in which they are preimpregnated with a wetting agent, thereafter kept separate from one another by spacers and then inserted in the module.
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公开(公告)号：JPS6159764B2
公开(公告)日：1986-12-18
申请号：JP9938678
申请日：1978-08-15
Applicant: TORAY INDUSTRIES
Inventor： KOBAYASHI TAKUICHI , SUGITA KOJI , FUJII YOSHINARI
IPC: B01D69/14
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公开(公告)号：JPH11104235A
公开(公告)日：1999-04-20
申请号：JP26673797
申请日：1997-09-30
Applicant: TORAY INDUSTRIES
Inventor： SONODA TAKESHI , SUGITA KOJI
Abstract: PROBLEM TO BE SOLVED: To provide a polysulfone type hollow fiber type artificial kidney which has high water permeability, is high in performance to remove uremic substances and is excellent in terms of safety without the admission of permeation of endotoxin even if this artificial kidney has moderate albumin permeability. SOLUTION: This process for production consists in confining the solvent remaining in the hollow fibers of the artificial kidney comprising the hollow fiber membranes consisting of a polysulfone resin contg. a hydrophilic high- molecular material to a specific value or below by washing, then executing a sterilization treatment by using gamma rays and electron beams and insolubilizing the hydrophilic high-molecular material by crosslinking. As a result, the permeability of the albumin is specified to >=0.2 to
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公开(公告)号：JPH0970431A
公开(公告)日：1997-03-18
申请号：JP15220196
申请日：1996-06-13
Applicant: TORAY INDUSTRIES
Inventor： SONODA TAKESHI , SUGITA KOJI , KOBAYASHI TAKUICHI , TANAKA KAZUSANE
Abstract: PROBLEM TO BE SOLVED: To easily produce the artificial kidney having high water permeability and adequate albumin permeability by setting the viscosity and water volume of a stock soln. for spinning contg. a polysulfone resin and hydrophilic high polymer to specific ranges and impregnating the hollow fibers spun from this stock soln. for spinning with a swelling holding material. SOLUTION: The stock soln. for spinning which has the range from 25 to 130 poises in the viscosity (x) (poise) at 30 deg.C of the stock soln. for spinning contg. the polysulfone resin and the hydrophilic high polymer and has the range satisfying the equation -0.01x+1.45
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公开(公告)号：JPH0734314A
公开(公告)日：1995-02-03
申请号：JP20282693
申请日：1993-07-22
Applicant: TORAY INDUSTRIES
Inventor： NODA YORIO , SUGITA KOJI , KAGEYAMA KATSUAKI
Abstract: PURPOSE:To provide a method for cleaning hollow filament films, short in washing time and reduced in consumption of cleaning water. CONSTITUTION:Hollow filament films are stored in cleaning baskets 70 and the cleaning baskets 70 are placed on a rotatable turntable 40. The cleaning baskets 70 are rotated, and sprayed with cleaning water by a jetting means 50 to remove a solvent remaining in the interior of the hollow filament films.
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