公开(公告)号：JPH11104236A

公开(公告)日：1999-04-20

申请号：JP26864997

申请日：1997-10-01

Applicant: TORAY INDUSTRIES

Inventor： YOKOYAMA AKIRA ,  MURAO YASUO ,  HOTTA OSAMU

IPC: A61M1/36

Abstract: PROBLEM TO BE SOLVED: To make it possible to selectively remove activated macrophage playing a central role in excess production of inflammatory cytokinins, etc., by using a polymixin immobilized carrier in a body fluid purifying column for removing the activated macrophage. SOLUTION: The polymyxin immobilized carrier is used in the column for removing the activated macrophage, more particularly CD16 antigen positive microphage, CD14 antigen positive and CD16 antigen positive macrophage. The polymyxin is preferably a fibrous carrier as the carrier used as the antibiotic substance produced by Bacillus polymax. The component of the fibrous carrier preferably consists of a high molecular substance. Polystyrene fibers, crosslinked polystyrene fibers, etc., are useful as the high molecular substance. The carrier having a substituent immobilizing the polymyxin, for example, the fibrous carrier having the substituent selected from α-acyl halide, etc., is preferably used.