中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

17 records (took 0.023 seconds)

    PRODUCTION OF D-ASPARTIC ACID
    2.
    发明专利
    PRODUCTION OF D-ASPARTIC ACID 失效

    公开(公告)号：JPS6455193A

    公开(公告)日：1989-03-02

    申请号：JP20994987

    申请日：1987-08-24

    Applicant: TORAY INDUSTRIES

    Inventor： SATOU HARUYO ,  ITO NORIKO ,  IMAMURA SHINZO

    IPC: C12P41/00 ,  C12R1/01 ,  C12R1/05 ,  C12R1/185 ,  C12R1/20 ,  C12R1/38 ,  C12R1/40 ,  C12R1/425 ,  C12R1/645 ,  C12R1/72 ,  C12R1/78 ,  C12R1/84 ,  C12R1/88

    Abstract: PURPOSE:To selectively assimilate only L-aspartic acid and readily obtain D- aspartic acid, by cultivating a specific microorganism capable of assimilating only the L-aspartic acid in a culture medium containing DL-aspartic acid. CONSTITUTION:A microorganism, belonging to the genus Bacterium, Escherichia, Serratia Alcaligenes, Flavobacterium, Providencia, Pseudomonas, Debaryomyces, Hansenula, Pichia, Saccharomycopsis, Candida, Torulopsis, Cryptococcus, etc., and having selective assimilating ability to assimilate only L-aspartic acid without assimilating D-aspartic acid is cultivated in a culture medium containing DL-aspartic acid as a carbon and nitrogen sources. The resultant culture fluid is then subjected to centrifugation to remove the microbial cells therefrom and afford the aimed D-aspartic acid.

    PRODUCTION OF OPTICALLY ACTIVE 3-HYDROXYPYRROLIDINE
    4.
    发明专利
    PRODUCTION OF OPTICALLY ACTIVE 3-HYDROXYPYRROLIDINE 失效

    公开(公告)号：JPH0532620A

    公开(公告)日：1993-02-09

    申请号：JP18896791

    申请日：1991-07-29

    Applicant: TORAY INDUSTRIES

    Inventor： ITO NORIKO ,  SATOU HARUYO

    IPC: C07D207/12 ,  C07B57/00

    Abstract: PURPOSE:To produce optically active 3-hydroxypyrrolidine by optically resolving easily available RS-3-hydroxypyrrolidine with an industrially easily available optically active tartaric acid anilide as a resolving agent. CONSTITUTION:RS-3-hydroxypyrrolidine (e.g. quantitatively obtained by reducing commercially available RS-N-benzyl-3-hydroxypyrrolidine in the presence of Pd/C catalyst) is optically resolved with an optically active tartaric acid anilide (both of the D and L isomers can be used) of the formula (R is chlorine or nitro) as a resolving agent to produce an optically active 3-hydroxypyrrolidine. The optically active tartaric acid anilide is obtained in a high yield e.g. by reacting tartaric acid with acetic anhydride, reacting the produced diacetyl tartaric acid anhydride with p-chloro or nitro-aniline and subsequently hydrolyzing the reaction product. The optically resolving agent is produced from inexpensive raw materials in a high yield, is chemically highly stable, can be recovered from a diastereomer salt solution in a high yield without being racemized, and can again be used.

    PRODUCTION OF D-PHENYLALANINE
    5.
    发明专利
    PRODUCTION OF D-PHENYLALANINE 失效

    公开(公告)号：JPH0265797A

    公开(公告)日：1990-03-06

    申请号：JP21414888

    申请日：1988-08-29

    Applicant: TORAY INDUSTRIES

    Inventor： ITO NORIKO ,  SATOU HARUYO

    IPC: C12P41/00 ,  C12R1/645

    Abstract: PURPOSE:To efficiently obtain the subject compound capable of highly selectively assimilating only L-phenylalanine and useful as a pharmaceutical intermediate in a short time by culturing a specific microorganism in a DL-phenylalanine- containing culture medium. CONSTITUTION:A microorganism (e.g. Rhodosporidium.torulides ATCC10788), belonging to the genus Rhodotorula, Rhodosporidium or Providencia and having the ability to assimilate L-phenylalanine without assimilating D-phenylalanine is cultured in a DL-phenylalanine-containing culture medium and the objective compound is then isolated from the culture solution. Furthermore, the culture is preferably carried out by a flow addition culture method for dividedly adding the DL-phenylalanine.

    PRODUCTION OF D-ALANINE
    7.
    发明专利
    PRODUCTION OF D-ALANINE 失效

    公开(公告)号：JPS63198997A

    公开(公告)日：1988-08-17

    申请号：JP2970987

    申请日：1987-02-13

    Applicant: TORAY INDUSTRIES

    Inventor： ITO NORIKO ,  IMAMURA SHINZO ,  SATOU HARUYO

    IPC: C12P13/06 ,  C12P41/00 ,  C12R1/645 ,  C12R1/72 ,  C12R1/78 ,  C12R1/84 ,  C12R1/85 ,  C12R1/88

    Abstract: PURPOSE:To obtain D-alanine useful as an intermediate for drugs or an intermediate for sweeteners efficiently, by cultivating specific yeast in a medium containing DL-alanine. CONSTITUTION:Yeast belonging to the genus Candida, Saccharomycospsis, Pichia, Torulopsis, Cryptococcus, Hansenula or Torycosporon, capable of assimilating L-alanine but substantially not D-alanine, is cultivated in a medium containing DL-alanine as a single carbon source and a single nitrogen source and D-alanine is collected from the culture mixture. Candida humicola ATCC36992, etc., may be cited as the yeast.

    PRODUCTION OF OPTICALLY ACTIVE 1-(P-CHLOROPHENYL)-1-(2-PYRIDYL)-3-DIMETHYLAMINOPROPANE
    9.
    发明专利
    PRODUCTION OF OPTICALLY ACTIVE 1-(P-CHLOROPHENYL)-1-(2-PYRIDYL)-3-DIMETHYLAMINOPROPANE 失效

    公开(公告)号：JPH0474165A

    公开(公告)日：1992-03-09

    申请号：JP18645890

    申请日：1990-07-13

    Applicant: TORAY INDUSTRIES

    Inventor： ITO NORIKO ,  SATOU HARUYO

    IPC: C07D213/38 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4418 ,  A61P43/00 ,  C07B57/00

    Abstract: PURPOSE:To enable reutilization of a resolving agent and obtain the subject compound which is a medicine in high purity by optically resolving dl-1-(p- chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane using the specific readily available resolving agent. CONSTITUTION:dl-1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopr p-ane is optically resolved by using a benzenesulfonyl derivative of an optically active amino acid expressed by the formula (n is 0 or 1) as a resolving agent to afford the objective compound. As specific procedures, the aforementioned compound is initially brought into contact with the resolving agent in an amount of 0.5-3.0 mol, preferably 1.0-2.5 mol based on 1 mol aforementioned raw material in a solvent to prepare a diastereomer salt. At this time, 0.1-1.5 mol mineral acid such as hydrochloric acid or organic acid such as acetic acid may coexist there in. The resultant solution containing the formed diastereomer salt is then cooled, concentrated and separated to afford the objective compound. Furthermore, the above-mentioned resolving agent is obtained by, e.g. slowly adding benzenesulfonyl chloride dissolved in a solvent to an aqueous solution of an optically active amino acid regulated to pH 10.

    PRODUCTION OF OPTICALLY ACTIVE 1-BENZYL-3-HYDROXYPYRROLIDINE
    10.
    发明专利
    PRODUCTION OF OPTICALLY ACTIVE 1-BENZYL-3-HYDROXYPYRROLIDINE 失效

    公开(公告)号：JPH0413659A

    公开(公告)日：1992-01-17

    申请号：JP11448090

    申请日：1990-04-28

    Applicant: TORAY INDUSTRIES

    Inventor： ITO NORIKO ,  SATOU HARUYO

    IPC: C07D207/12 ,  C07B57/00

    Abstract: PURPOSE:To obtain the subject optically active compound, simultaneously recover a resolving agent in an ultrahigh yield and reuse the aforementioned agent by carrying out optical resolution using (RS)-1-benzyl-3-hydroxypyrrolidine with a specific optically active carboxylic acid as the resolving agent. CONSTITUTION:(RS)-1-Benzyl-3-hydroxypyrrolidine is optically resolved with an optically active carboxylic acid (e.g. p-toluenesulfonyl-D-phenylglycine) expressed by the formula (R is benzenesulfonyl, toluenesulfonyl, benzoyl or toluoyl) as a resolving agent to afford optically active 1-benzyl-3- hydroxypyrrolidine. The optically active carboxylic acid, used as the resolving agent and expressed by the formula is sparingly soluble and can be recovered from a diastereomer salt solution in an ultrahigh yield. Since the optical purity is held by the above-mentioned resolving agent, optical resolution can be carried out by reuse thereof.

Patent Agency Ranking