公开(公告)号：AT359858T

公开(公告)日：2007-05-15

申请号：AT00311580

申请日：2000-12-21

Applicant: TORAY INDUSTRIES

Inventor： KOZAWA HIDETOSHI ,  NAKASHIMA HIDEKAZU ,  WADA SHIGEHISA

IPC: A61M1/14 ,  A61M1/00 ,  A61M1/16 ,  A61M1/18 ,  B01D61/28 ,  B01D63/02 ,  B01D67/00 ,  B01D69/02 ,  B01D69/08 ,  B01D71/00 ,  B01D71/06 ,  B01D71/58 ,  B01D71/68 ,  D01D5/24

Abstract: A dialyzer for blood treatment has incorporated therein a semipermeable membrane which comprises a hydrophobic polymer and a hydrophilic polymer, the water permeating performance of the semipermeable membrane after drying being 1/2 or higher relative to that before drying and the dialyzer satisfying any one of the following requirements; (A) the vitamin B12 clearance is not smaller than 135 ml/min per 1.6 m ; and (B) the amount of the hydrophilic polymer that is eluted from the semipermeable membrane is not higher than 10 ppm. A dialyzer having incorporated therein a semipermeable membrane, which comprises a hydrophobic polymer and a hydrophilic polymer, can be produced by a process comprising: drying the semipermeable membrane; and saturating the dried semipermeable membrane with a water ratio of not smaller than 100% based on the dry weight of the semipermeable membrane, providing an inert gas atmosphere inside the dialyzer, and then irradiating the semipermeable membrane with gamma-rays in the inert gas atmosphere. In a process for producing a hollow fiber membrane for use in blood treatment through dry/wet spinning from a stock solution comprising 15 to 18% by weight of a hydrophobic polymer and 4 to 8% by weight of a hydrophilic polymer, the dry zone is filled with dry mist.

公开(公告)号：DE60034416T2

公开(公告)日：2008-01-03

申请号：DE60034416

申请日：2000-12-21

Applicant: TORAY INDUSTRIES

Inventor： KOZAWA HIDETOSHI ,  NAKASHIMA HIDEKAZU ,  WADA SHIGEHISA

IPC: A61M1/14 ,  B01D69/02 ,  A61M1/00 ,  A61M1/16 ,  A61M1/18 ,  B01D61/28 ,  B01D63/02 ,  B01D67/00 ,  B01D69/08 ,  B01D71/00 ,  B01D71/06 ,  B01D71/58 ,  B01D71/68 ,  D01D5/24

Abstract: A dialyzer for blood treatment has incorporated therein a semipermeable membrane which comprises a hydrophobic polymer and a hydrophilic polymer, the water permeating performance of the semipermeable membrane after drying being 1/2 or higher relative to that before drying and the dialyzer satisfying any one of the following requirements; (A) the vitamin B12 clearance is not smaller than 135 ml/min per 1.6 m ; and (B) the amount of the hydrophilic polymer that is eluted from the semipermeable membrane is not higher than 10 ppm. A dialyzer having incorporated therein a semipermeable membrane, which comprises a hydrophobic polymer and a hydrophilic polymer, can be produced by a process comprising: drying the semipermeable membrane; and saturating the dried semipermeable membrane with a water ratio of not smaller than 100% based on the dry weight of the semipermeable membrane, providing an inert gas atmosphere inside the dialyzer, and then irradiating the semipermeable membrane with gamma-rays in the inert gas atmosphere. In a process for producing a hollow fiber membrane for use in blood treatment through dry/wet spinning from a stock solution comprising 15 to 18% by weight of a hydrophobic polymer and 4 to 8% by weight of a hydrophilic polymer, the dry zone is filled with dry mist.

公开(公告)号：DE60034416D1

公开(公告)日：2007-05-31

申请号：DE60034416

申请日：2000-12-21

Applicant: TORAY INDUSTRIES

Inventor： KOZAWA HIDETOSHI ,  NAKASHIMA HIDEKAZU ,  WADA SHIGEHISA

IPC: A61M1/14 ,  B01D69/02 ,  A61M1/00 ,  A61M1/16 ,  A61M1/18 ,  B01D61/28 ,  B01D63/02 ,  B01D67/00 ,  B01D69/08 ,  B01D71/00 ,  B01D71/06 ,  B01D71/58 ,  B01D71/68 ,  D01D5/24

Abstract: A dialyzer for blood treatment has incorporated therein a semipermeable membrane which comprises a hydrophobic polymer and a hydrophilic polymer, the water permeating performance of the semipermeable membrane after drying being 1/2 or higher relative to that before drying and the dialyzer satisfying any one of the following requirements; (A) the vitamin B12 clearance is not smaller than 135 ml/min per 1.6 m ; and (B) the amount of the hydrophilic polymer that is eluted from the semipermeable membrane is not higher than 10 ppm. A dialyzer having incorporated therein a semipermeable membrane, which comprises a hydrophobic polymer and a hydrophilic polymer, can be produced by a process comprising: drying the semipermeable membrane; and saturating the dried semipermeable membrane with a water ratio of not smaller than 100% based on the dry weight of the semipermeable membrane, providing an inert gas atmosphere inside the dialyzer, and then irradiating the semipermeable membrane with gamma-rays in the inert gas atmosphere. In a process for producing a hollow fiber membrane for use in blood treatment through dry/wet spinning from a stock solution comprising 15 to 18% by weight of a hydrophobic polymer and 4 to 8% by weight of a hydrophilic polymer, the dry zone is filled with dry mist.

公开(公告)号：CA2329103A1

公开(公告)日：2001-06-21

申请号：CA2329103

申请日：2000-12-20

Applicant: TORAY INDUSTRIES

Inventor： WADA SHIGEHISA ,  NAKASHIMA HIDEKAZU ,  KOZAWA HIDETOSHI

IPC: A61M1/14 ,  A61M1/00 ,  A61M1/16 ,  A61M1/18 ,  B01D61/28 ,  B01D63/02 ,  B01D67/00 ,  B01D69/02 ,  B01D69/08 ,  B01D71/00 ,  B01D71/06 ,  B01D71/58 ,  B01D71/68 ,  D01D5/24

Abstract: The present invention relates to a dialyzer for blood treatment having incorporated therein a semipermeable membrane which comprises a hydrophobic polymer and a hydrophilic polymer, the water permeating performance of the semipermeable membrane after drying being 1/2 or higher relative to that before drying and the dialyzer satisfying any of the following requirements: (A) the vitamin B12 clearance is not smaller than 135 ml/min per 1.6 m2; and (B) the amount of the hydrophilic polymer that is eluted from the semipermeable membrane is not higher than 10 ppm. The invention also relates to a process for producing a dialyzer having incorporated therein a semipermeable membrane which comprises a hydrophobic polymer and a hydrophilic polymer, the process comprising: drying the semipermeable membrane; and saturating the dried semipermeable membrane with water ratio of not smaller than 100% based on the dry weight of the semipermeable membrane, providing an inert gas atmosphere to the inside of the dialyzer, and then irradiating the semipermeable membrane with gamma-ray in the inert gas atmosphere. The invention further relates to a process for producing a hollow fiber membrane for use in blood treatment through dry/wet spinning from a stock solution comprising 15 to 18% by weight of a hydrophobic polymer and 4 to 8% by weight of a hydrophilic polymer, the dry zone being filled with dry mist. The dialyzer includes a dry-type semipermeable membrane having less change in performance before and after drying and high water permeability and dialyzing performance, is light-weight, easy to handle, and exhibits a reduced elution of a hydrophilic polymer.

公开(公告)号：CA2329103C

公开(公告)日：2009-06-09

申请号：CA2329103

申请日：2000-12-20

Applicant: TORAY INDUSTRIES

Inventor： NAKASHIMA HIDEKAZU ,  KOZAWA HIDETOSHI ,  WADA SHIGEHISA

IPC: A61M1/14 ,  A61M1/16 ,  A61M1/00 ,  A61M1/18 ,  B01D61/28 ,  B01D63/02 ,  B01D67/00 ,  B01D69/02 ,  B01D69/08 ,  B01D71/00 ,  B01D71/06 ,  B01D71/58 ,  B01D71/68 ,  D01D5/24

Abstract: The present invention relates to a dialyzer for blood treatment having incorporated therein a semipermeable membrane which comprises a hydrophobic polymer and a hydrophilic polymer, the water permeating performance of the semipermeable membrane after drying being 1/2 or higher relative to that before drying and the dialyzer satisfying any of the following requirements: (A) the vitamin B12 clearance is not smaller than 135 ml/min per 1.6 m2; and (B) the amount of the hydrophilic polymer that is eluted from the semipermeable membrane is not higher than 10 ppm. The invention also relates to a process for producing a dialyzer having incorporated therein a semipermeable membrane which comprises a hydrophobic polymer and a hydrophilic polymer, the process comprising: drying the semipermeable membrane; and saturating the dried semipermeable membrane with water ratio of not smaller than 100% based on the dry weight of the semipermeable membrane, providing an inert gas atmosphere to the inside of the dialyzer, and then irradiating the semipermeable membrane with gamma-ray in the inert gas atmosphere. The invention further relates to a process for producing a hollow fiber membrane for use in blood treatment through dry/wet spinning from a stock solution comprising 15 to 18% by weight of a hydrophobic polymer and 4 to 8% by weight of a hydrophilic polymer, the dry zone being filled with dry mist. The dialyzer includes a dry-type semipermeable membrane having less change in performance before and after drying and high water permeability and dialyzing performance, is light-weight, easy to handle, and exhibits a reduced elution of a hydrophilic polymer.

公开(公告)号：ES2285998T3

公开(公告)日：2007-12-01

申请号：ES00311580

申请日：2000-12-21

Applicant: TORAY INDUSTRIES

Inventor： KOZAWA HIDETOSHI ,  NAKASHIMA HIDEKAZU ,  WADA SHIGEHISA

IPC: A61M1/14 ,  B01D69/02 ,  A61M1/00 ,  A61M1/16 ,  A61M1/18 ,  B01D61/28 ,  B01D63/02 ,  B01D67/00 ,  B01D69/08 ,  B01D71/00 ,  B01D71/06 ,  B01D71/58 ,  B01D71/68 ,  D01D5/24

Abstract: Dializador para el tratamiento de la sangre que tiene incorporado una membrana semipermeable de fibra hueca que comprende un polímero hidrofóbico y un polímero hidrofílico, cuyo rendimiento de permeación del agua de la membrana semipermeable después del secado a 100ºC y durante 24 h es la 1/2 o más respecto al rendimiento antes del secado; y en donde dicho dializador satisface los requisitos siguientes: (A) Que el aclaramiento de la vitamina B12 no sea inferior a 135 ml/min por 1, 6 m2; y (B) Que la cantidad del polímero hidrofílico que se eluye de la membrana semipermeable en un test de elución forzada no sea superior a 10 ppm.

公开(公告)号：EP1027899A4

公开(公告)日：2006-08-09

申请号：EP99940534

申请日：1999-08-27

Applicant: TORAY INDUSTRIES

Inventor： NAKASHIMA HIDEKAZU ,  SUGAYA HIROYUKI ,  MATSUMOTO HIROSHI ,  KAWASHIMA MADOKA ,  ICHIKAWA KATSUYOSHI ,  UESAKA TSUTOMU

IPC: A61M1/16 ,  A61M1/18 ,  A61M1/36 ,  B01D63/02 ,  A61M1/14 ,  A61B1/00

CPC classification number: A61M1/16 ,  A61M1/3606 ,  A61M1/3672 ,  B01D63/02 ,  B01D2313/21

Abstract: A blood processing device involving a small amount of remaining blood, comprising a hollow fiber module fixed to a housing by a partition wall with an end thereof opened and a blood port mounted to the opened end face and provided with a blood inlet, characterized in that an inclination theta of the inner wall of the blood inlet provided to the blood port with respect to the center axis of the blood port is not larger than 1.5 DEG and a relation 0.08D

Abstract translation: 一种含有少量剩余血液的血液处理装置，其特征在于，包括：中空纤维模块，其通过分隔壁开封而封闭在壳体上，血管端口安装在所述开口端面并具有血液入口，其特征在于： 一种倾向和倾向; 相对于血液口的中心轴线设置在血液口的血液入口的内壁不大于1.5度，关系为0.08D≤h≤0.13D，其中Q是a 虚拟线通过血液口内表面的端部（P）并且直角地跨越分隔壁和血液端口顶面的虚拟延伸线，点Q与分隔壁之间的距离，以及D的直径 血液端口内端，血液处理装置适用于血液净化，血液透析和超滤。