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公开(公告)号：DK1886704T3
公开(公告)日：2017-01-16
申请号：DK06730892
申请日：2006-03-31
Applicant: TORAY INDUSTRIES
Inventor： SHIMAGAKI MASAAKI , YAMAMURA YASUFUMI , SATO KATSUHISA , TERAMOTO KAZUO , OOZEKI TAKESHIGE , WADA SHIGEHISA
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公开(公告)号：ES2380538T3
公开(公告)日：2012-05-16
申请号：ES04787627
申请日：2004-09-06
Applicant: TORAY INDUSTRIES
Inventor： WADA SHIGEHISA , UTSUMI JUN , FUJITA YOSHIJI , SUGAYA HIROYUKI , YAMADA SATOKO
IPC: C07K1/22 , B01D63/02 , B01D69/02 , C07K1/14 , C07K1/34 , C07K1/36 , C12M1/00 , C12P1/00 , G01N1/40 , G01N33/68
Abstract: Un procedimiento de preparación de una solución para análisis proteómico que tiene una composición cambiada de componentes biológicos en la que la proporción de concentración de albúmina en las proteínas totales es menor de 0,3 y la proporción de concentración de β2-microglobulina en las proteínas totales es al menos 10 veces más alta que la proporción de concentración en la solución de partida que contiene componentes biológicos, comprendiendo el procedimiento someter la solución que contiene componentes biológicos a tratamiento en al menos dos etapas; en el que las dos etapas se seleccionan entre (1) una etapa de adsorción de una parte o todas las proteínas que tienen un peso molecular igual o superior al de la albúmina; (2) una etapa de retiro de una parte o todas las proteínas que tienen un peso molecular igual o superior al de la albúmina mediante fraccionamiento con un tamiz molecular; y (3) una etapa de concentración de proteínas, en donde se emplea en la etapa (1) o la etapa (2) una membrana de separación de fibra hueca de polisulfona que contiene canales de flujo que tienen una estructura asimétrica que se deriva de polisulfona y poli(vinilpirrolidona) y tiene una proporción de permeación comparativa de β2-microglobulina con respecto a albúmina, definida como coeficiente de tamizado de β2-microglobulina, coeficiente de tamizado de albúmina de al menos 50.
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公开(公告)号：AT359858T
公开(公告)日：2007-05-15
申请号：AT00311580
申请日：2000-12-21
Applicant: TORAY INDUSTRIES
Inventor： KOZAWA HIDETOSHI , NAKASHIMA HIDEKAZU , WADA SHIGEHISA
IPC: A61M1/14 , A61M1/00 , A61M1/16 , A61M1/18 , B01D61/28 , B01D63/02 , B01D67/00 , B01D69/02 , B01D69/08 , B01D71/00 , B01D71/06 , B01D71/58 , B01D71/68 , D01D5/24
Abstract: A dialyzer for blood treatment has incorporated therein a semipermeable membrane which comprises a hydrophobic polymer and a hydrophilic polymer, the water permeating performance of the semipermeable membrane after drying being 1/2 or higher relative to that before drying and the dialyzer satisfying any one of the following requirements; (A) the vitamin B12 clearance is not smaller than 135 ml/min per 1.6 m ; and (B) the amount of the hydrophilic polymer that is eluted from the semipermeable membrane is not higher than 10 ppm. A dialyzer having incorporated therein a semipermeable membrane, which comprises a hydrophobic polymer and a hydrophilic polymer, can be produced by a process comprising: drying the semipermeable membrane; and saturating the dried semipermeable membrane with a water ratio of not smaller than 100% based on the dry weight of the semipermeable membrane, providing an inert gas atmosphere inside the dialyzer, and then irradiating the semipermeable membrane with gamma-rays in the inert gas atmosphere. In a process for producing a hollow fiber membrane for use in blood treatment through dry/wet spinning from a stock solution comprising 15 to 18% by weight of a hydrophobic polymer and 4 to 8% by weight of a hydrophilic polymer, the dry zone is filled with dry mist.
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公开(公告)号：ES2605406T3
公开(公告)日：2017-03-14
申请号：ES05703866
申请日：2005-01-20
Applicant: TORAY INDUSTRIES
Inventor： TANAHASHI KAZUHIRO , KUMO ICHIRO , KUROKI NOBUYUKI , SUGAYA HIROYUKI , YAMADA SATOKO , WADA SHIGEHISA , JUNG GIMAN , KURODA TOSHIHIKO , SEKIGUCHI SHUJI
Abstract: Un dispositivo de fraccionamiento para separar solutos en un liquido bruto mediante una membrana, que comprende 1) una parte de suministro (2b) para cargar el liquido bruto; 2) una parte de filtracion con una membrana (5a; 5b; 5c) para filtrar algo de los solutos en el liquido bruto enviado desde la parte de suministro; 3) una parte de concentracion (5d) para concentrar el filtrado procedente de la parte de filtracion; 4) una parte de recuperacion (10) para recuperar la solucion concentrada obtenida en la parte de concentracion; 5) una bomba de flujo para el envio de una fase movil; en el que la bomba de flujo es una bomba de tubo provista de un rotor giratorio y de un rodillo (9) instalado de manera giratoria en la circunferencia exterior del rotor; caracterizado por que la parte de suministro, la parte de filtracion, la parte de concentracion, la parte de recuperacion y un canal de flujo que conecta las partes respectivas, forman un circuito cerrado y estan ensamblados en un cartucho desechable (14) en el que al menos las porciones de los canales de flujo estan expuestas a la pared exterior del cartucho desde el exterior del cartucho, y por que el cartucho se puede separar del rodillo de la bomba de flujo y esta dispuesto de manera que una parte de la pared exterior del cartucho funciona como un miembro de compresion mediante el acoplamiento de la bomba de rodillos para comprimir las porciones expuestas de los canales de flujo cuando el rodillo se hace girar para hacer circular los liquidos en las partes respectivas del cartucho.
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公开(公告)号：CA2537209C
公开(公告)日：2013-05-14
申请号：CA2537209
申请日：2004-09-06
Applicant: TORAY INDUSTRIES
Inventor： WADA SHIGEHISA , UTSUMI JUN , FUJITA YOSHIJI , SUGAYA HIROYUKI , YAMADA SATOKO
Abstract: The invention provides a method of preparing a biological components-containing solution suitable for clinical proteome analysis by mass spectrometry, electrophoresis, liquid chromatography or the like and an apparatus for the method. The method of the invention is a method for combining two steps among steps of (1) adsorbing proteins having a molecular weight equal to or higher than that of albumin; (2) fractionating proteins having a molecular weight equal to or higher than that of albumin; and (3) concentrating proteins; or a method for preparing the solution by separation using a membrane separation unit having a comparative permeation ratio of 50 or higher for proteins with a molecular weight less than 15,000 and proteins with a molecular weight of 60,000 or higher; or a method for preparing the solution by introducing a biological components-containing raw solution into a separation membrane module and successively passing a diluting solution for circulating the solution and passing a portion of the solution through a separation membrane.
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Patent Agency Ranking
公开(公告)号：DE60034416T2
公开(公告)日：2008-01-03
申请号：DE60034416
申请日：2000-12-21
Applicant: TORAY INDUSTRIES
Inventor： KOZAWA HIDETOSHI , NAKASHIMA HIDEKAZU , WADA SHIGEHISA
IPC: A61M1/14 , B01D69/02 , A61M1/00 , A61M1/16 , A61M1/18 , B01D61/28 , B01D63/02 , B01D67/00 , B01D69/08 , B01D71/00 , B01D71/06 , B01D71/58 , B01D71/68 , D01D5/24
Abstract: A dialyzer for blood treatment has incorporated therein a semipermeable membrane which comprises a hydrophobic polymer and a hydrophilic polymer, the water permeating performance of the semipermeable membrane after drying being 1/2 or higher relative to that before drying and the dialyzer satisfying any one of the following requirements; (A) the vitamin B12 clearance is not smaller than 135 ml/min per 1.6 m ; and (B) the amount of the hydrophilic polymer that is eluted from the semipermeable membrane is not higher than 10 ppm. A dialyzer having incorporated therein a semipermeable membrane, which comprises a hydrophobic polymer and a hydrophilic polymer, can be produced by a process comprising: drying the semipermeable membrane; and saturating the dried semipermeable membrane with a water ratio of not smaller than 100% based on the dry weight of the semipermeable membrane, providing an inert gas atmosphere inside the dialyzer, and then irradiating the semipermeable membrane with gamma-rays in the inert gas atmosphere. In a process for producing a hollow fiber membrane for use in blood treatment through dry/wet spinning from a stock solution comprising 15 to 18% by weight of a hydrophobic polymer and 4 to 8% by weight of a hydrophilic polymer, the dry zone is filled with dry mist.
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公开(公告)号：CA2578202A1
公开(公告)日：2006-03-09
申请号：CA2578202
申请日：2005-08-30
Applicant: TORAY INDUSTRIES
Inventor： TANAHASHI KAZUHIRO , WADA SHIGEHISA , SUGAYA HIROYUKI , TAKAHASHI HIROSHI
IPC: C07K1/22 , A61J3/00 , A61L31/00 , A61M1/18 , A61M25/00 , C07K1/34 , C08J7/12 , C08L101/00 , C12M1/00
Abstract: The present invention discloses a fractionation device used for proteins and/or peptides, which has any of the following features: 1) At least one portion of a substrate surface with which proteins or the like are made in contact has an amount of adsorption of bovine serum albumin of 50 ng/cm 2 or less with respect to the substrate surface, when a bovine serum albumin solution is made in contact therewith. 2) At least one portion of a substrate surface with which proteins or the like are made in contact has an amount of adsorption of human ²2-microglobulin of 3 ng/cm 2 or less with respect to the substrate surface, when a protein aqueous solution consisting of human ²2-microglobulin and bovine serum albumin is made in contact with the substrate surface. 3) The fractionation device is provided with: a means for supplying a solution containing proteins or the like; a means for separating proteins or the like from the solution; and a means for concentrating proteins or the like in the solution, and in the fractionation device, at least one portion of the substrate surface with which proteins or the like are made in contact is subj ected to a grafting process by using a hydrophilic polymer. By using the above-mentioned device, it becomes possible to reduce non-peculiar adsorption of protein onto the substrate, and consequently to easily provide a sample from which proteins having high-molecular weights have been removed, and which is advantageously used for an analysis.
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公开(公告)号：CA2553234C
公开(公告)日：2012-07-24
申请号：CA2553234
申请日：2005-01-20
Applicant: TORAY INDUSTRIES
Inventor： TANAHASHI KAZUHIRO , KUMO ICHIRO , KUROKI NOBUYUKI , SUGAYA HIROYUKI , YAMADA SATOKO , WADA SHIGEHISA , JUNG GIMAN , KURODA TOSHIHIKO , SEKIGUCHI SHUJI
Abstract: The following is disclosed: (1) a membrane fractionator including a filtration section, a concentrating section, a recovery section and a liquid feed pump, wherein a flow channel connecting the filtration section, concentrating section and recovery section to each other constitutes a closed circuitry; (2) a method of biocomponent separation, characterized in that a sample derived from biocomponents is fed into an antibody adsorption membrane separation system having an antibody capable of adsorbing specified protein internally accommodated in the middle or a rear part of a membrane separation system that in the absence of antibodies adsorbing proteins, exhibits a permeation ratio between human &agr;1-microglobulin and human albumin of 1.5 to 1000, thereby separating part of the biocomponents; and (3) a method of protein fractionation, comprising bringing a solution containing two or more types of proteins and water into contact with a hollow yarn separation membrane to thereby attain protein fractionation, characterized in that the fractionation solution contains an organic solvent.
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公开(公告)号：CA2329103C
公开(公告)日：2009-06-09
申请号：CA2329103
申请日：2000-12-20
Applicant: TORAY INDUSTRIES
Inventor： NAKASHIMA HIDEKAZU , KOZAWA HIDETOSHI , WADA SHIGEHISA
IPC: A61M1/14 , A61M1/16 , A61M1/00 , A61M1/18 , B01D61/28 , B01D63/02 , B01D67/00 , B01D69/02 , B01D69/08 , B01D71/00 , B01D71/06 , B01D71/58 , B01D71/68 , D01D5/24
Abstract: The present invention relates to a dialyzer for blood treatment having incorporated therein a semipermeable membrane which comprises a hydrophobic polymer and a hydrophilic polymer, the water permeating performance of the semipermeable membrane after drying being 1/2 or higher relative to that before drying and the dialyzer satisfying any of the following requirements: (A) the vitamin B12 clearance is not smaller than 135 ml/min per 1.6 m2; and (B) the amount of the hydrophilic polymer that is eluted from the semipermeable membrane is not higher than 10 ppm. The invention also relates to a process for producing a dialyzer having incorporated therein a semipermeable membrane which comprises a hydrophobic polymer and a hydrophilic polymer, the process comprising: drying the semipermeable membrane; and saturating the dried semipermeable membrane with water ratio of not smaller than 100% based on the dry weight of the semipermeable membrane, providing an inert gas atmosphere to the inside of the dialyzer, and then irradiating the semipermeable membrane with gamma-ray in the inert gas atmosphere. The invention further relates to a process for producing a hollow fiber membrane for use in blood treatment through dry/wet spinning from a stock solution comprising 15 to 18% by weight of a hydrophobic polymer and 4 to 8% by weight of a hydrophilic polymer, the dry zone being filled with dry mist. The dialyzer includes a dry-type semipermeable membrane having less change in performance before and after drying and high water permeability and dialyzing performance, is light-weight, easy to handle, and exhibits a reduced elution of a hydrophilic polymer.
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10.发明专利
公开(公告)号：ES2285998T3
公开(公告)日：2007-12-01
申请号：ES00311580
申请日：2000-12-21
Applicant: TORAY INDUSTRIES
Inventor： KOZAWA HIDETOSHI , NAKASHIMA HIDEKAZU , WADA SHIGEHISA
IPC: A61M1/14 , B01D69/02 , A61M1/00 , A61M1/16 , A61M1/18 , B01D61/28 , B01D63/02 , B01D67/00 , B01D69/08 , B01D71/00 , B01D71/06 , B01D71/58 , B01D71/68 , D01D5/24
Abstract: Dializador para el tratamiento de la sangre que tiene incorporado una membrana semipermeable de fibra hueca que comprende un polímero hidrofóbico y un polímero hidrofílico, cuyo rendimiento de permeación del agua de la membrana semipermeable después del secado a 100ºC y durante 24 h es la 1/2 o más respecto al rendimiento antes del secado; y en donde dicho dializador satisface los requisitos siguientes: (A) Que el aclaramiento de la vitamina B12 no sea inferior a 135 ml/min por 1, 6 m2; y (B) Que la cantidad del polímero hidrofílico que se eluye de la membrana semipermeable en un test de elución forzada no sea superior a 10 ppm.
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