公开(公告)号：JPH1129587A

公开(公告)日：1999-02-02

申请号：JP18820497

申请日：1997-07-14

Applicant: TORAY INDUSTRIES

Inventor： TSURUOKA HISASHI ,  IMAMURA SHINZO

IPC: C07D213/74 ,  C07F9/10

Abstract: PROBLEM TO BE SOLVED: To obtain the subject substance easy to handle and usable for synthesis of highly pure phosphatidic acid, by making glycerol-3-hosphate which is highly hygroscopic and hard to handle, carry on a solid. SOLUTION: This substance is obtained by making glycerol-3-phosphate (hereafter, G3P) carry on a solid (preferably, silica gel, almina, Super Flow Cel, Celite or a resin), wherein, the solid is added to G3P solution (preferably, methanol, ethanol, propanol, butanol, etc., is preferably used as a solvent), then, the solvent is distilled for drying. The temperature for dying G3P is preferably 30-150 deg.C. By reacting the solid-carried G3P with an activated fatty acid (preferably, a chlorinated or bromated fatty acid anhydride), highly pure phosphatidic acid can be obtained in high yield.

公开(公告)号：JP2000302711A

公开(公告)日：2000-10-31

申请号：JP11605799

申请日：1999-04-23

Applicant: TORAY INDUSTRIES

Inventor： TSURUOKA HISASHI ,  SHIBAYAMA KATSUHIRO

IPC: C07C29/147 ,  C07C31/36 ,  C07C33/46

Abstract: PROBLEM TO BE SOLVED: To produce a β-substituted alcohol in high yield by reducing an α- substituted ester with an alkali metal borohydride. SOLUTION: The objective compound is produced by reducing (A) an α- substituted ester of formula [R1 is H, a (substituted)1-21C saturated hydrocarbon group, an unsaturated hydrocarbon group, an aralkyl or an aromatic hydrocarbon group; X is an electron attracting group; and R2 is a 1-9C alkyl] (e.g. ethyl 2-chloropropionate, methyl 2-bromobutanoate and methyl 2-chloro-2- phenylacetate) with (B) an alkali metal borohydride (e.g. sodium borohydride) preferably in a polar solvent [e.g. simple ethanol or a mixture of isopropanol and methanol or isopropanol and ethanol at a volume ratio of 5:1 to 10:1]. The mixing molar ratio of the component A to the component B is preferably 1:(0.5-5).