公开(公告)号：JP2014060959A

公开(公告)日：2014-04-10

申请号：JP2012208510

申请日：2012-09-21

Applicant: Toshiba Corp ,  株式会社東芝

Inventor： NAKAMURA NAOKO ,  ITO KEIKO ,  HASHIMOTO KOJI ,  MOTOMA NOBUHIRO ,  NIKAIDO MASARU

IPC: C12N15/09 ,  C12M1/00 ,  C12Q1/68

Abstract: PROBLEM TO BE SOLVED: To provide a multiple nucleic acid reaction tool, a nucleic acid analysis method and an assay kit, capable of carrying out amplification reaction and hybridization reaction in one reaction field.SOLUTION: The method includes the steps of: preparing a sample, a base substance 2, a primer set 7 for amplifying target nucleic acid, and a nucleic acid probe 6 for detecting an amplified product; coating salt 8 with hardened oil or wax 9; immobilizing a nucleic acid probe on the surface of the base substance; immobilizing the primer set at the same location as the nucleic acid probe; bringing reaction mixture containing the sample and the coated salt capsule into contact with the nucleic acid probe and the primer set on the base substance, thereby amplifying target nucleic acid; melting hardened oil or wax by elevating the temperature of the reaction mixture, and eluting the salt; hybridizing the amplified product obtained by the amplification reaction with the nucleic acid probe; and measuring a produced hybridization signal to detect the presence or absence and/or quantity of target nucleic acid in the sample.

Abstract translation: 要解决的问题：提供能够在一个反应​​场中进行扩增反应和杂交反应的多重核酸反应工具，核酸分析方法和测定试剂盒。方法：该方法包括以下步骤：制备样品 ，碱基物质2，用于扩增靶核酸的引物组7和用于检测扩增产物的核酸探针6; 用硬化油或蜡9涂覆盐8; 将核酸探针固定在基础物质的表面上; 将引物组固定在与核酸探针相同的位置; 使含有样品和包衣盐胶囊的反应混合物与核酸探针和底物上的引物组接触，从而扩增靶核酸; 通过升高反应混合物的温度和洗脱该盐来熔化硬化油或蜡; 将通过扩增反应获得的扩增产物与核酸探针杂交; 并测量产生的杂交信号以检测样品中靶核酸的存在或不存在和/或量。

公开(公告)号：JP2009244186A

公开(公告)日：2009-10-22

申请号：JP2008092964

申请日：2008-03-31

Applicant: Toshiba Corp ,  Toshiba Hokuto Electronics Corp ,  東芝ホクト電子株式会社 ,  株式会社東芝

Inventor： TSUBOSAKI KAZUHIRO ,  KAMIIDE HIROTAKA ,  TSUJI KOICHI ,  ONODERA MAKOTO ,  NIKAIDO MASARU

IPC: G01N27/416 ,  G01N33/53 ,  G01N37/00

Abstract: PROBLEM TO BE SOLVED: To provide a DNA chip measuring device capable of efficiently cleaning a probe pin. SOLUTION: This measuring device includes a cassette supporting mechanism 62 disposed movably between a mounting position allowing removal of a cassette storing the DNA chip and a measuring position allowing measurement of the DNA chip, a measurement probe pin 76 that is disposed movably between an abutting position abutting on an electrode of the DNA chip in the cassette having moved to the measuring position and an evacuating position separated from the cassette and detects generated current from the DNA chip, a cleaning cassette 52 that is formed mountably in a cassette support mechanism instead of the cassette and has a cleaning layer 56b for cleaning the measurement probe pin, and a driving mechanism for moving the measurement probe pin between the evacuating position and the abutting position, butting the measurement probe pin to the measuring pole of the DNA chip during measurement, and bringing the measurement probe pin into contact with the cleaning layer of the cleaning cassette having been moved to the measuring position during cleaning. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供能够有效地清洁探针的DNA芯片测量装置。 解决方案：该测量装置包括：盒支撑机构62，其可移动地设置在允许去除存储DNA芯片的盒的安装位置和允许测量DNA芯片的测量位置之间;测量探针76可移动地设置在 邻接在移动到测量位置的盒中的DNA芯片的电极上的邻接位置和从盒子分离的抽空位置并检测从DNA芯片产生的电流;安装在盒支撑机构中的清洁盒52 代替盒，并具有用于清洁测量用探针的清洁层56b和用于使测定用探针在排气位置与抵接位置之间移动的驱动机构，将测定用探针固定在DNA芯片的测定极上 测量，并使测量探针与清洁盒的清洁层接触 清洁过程中已经移动到测量位置。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：JP2009192494A

公开(公告)日：2009-08-27

申请号：JP2008036260

申请日：2008-02-18

Applicant: Toshiba Corp ,  株式会社東芝

Inventor： NIKAIDO MASARU

IPC: G01N27/416 ,  C12M1/00 ,  C12N15/09 ,  G01N27/28 ,  G01N27/327 ,  G01N33/53 ,  G01N37/00

Abstract: PROBLEM TO BE SOLVED: To provide a DNA chip that accurately determines a difference of a single base, by suppressing variations in the temperature distribution, in an electrode section of a substrate. SOLUTION: This DNA chip comprises the substrate 30 which has insulation properties; a plurality of electrodes 32 formed of a conductive metal film formed on one surface of the substrate; an insulating layer 42 that is formed on one surface of the substrate and covers the periphery of the electrodes; a DNA probe 41 fixed onto at least one electrode; and an inorganic film 50 that is disposed on the other surface of the substrate, in a manner of facing a predetermined heating region that includes the electrodes to which the DAN probe is fixed, and maintains the heating region at a fixed heat distribution. COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：提供一种通过抑制基板的电极部分中的温度分布的变化来准确地确定单个碱基的差异的DNA芯片。 解决方案：该DNA芯片包括具有绝缘性能的基板30; 由形成在基板的一个表面上的导电金属膜形成的多个电极32; 绝缘层42，其形成在基板的一个表面上并覆盖电极的周边; 固定在至少一个电极上的DNA探针41; 以及设置在基板的另一个表面上的无机膜50，其面向包括固定有DAN探针的电极的预定加热区域，并将加热区域保持在固定的热分布。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2005197047A

公开(公告)日：2005-07-21

申请号：JP2004001049

申请日：2004-01-06

Applicant: Toshiba Corp ,  株式会社東芝

Inventor： SHIMAYAMA KENTARO ,  NIKAIDO MASARU ,  ISHIKAWA SATOSHI

IPC: H01J29/87 ,  H01J29/06 ,  H01J31/12

Abstract: PROBLEM TO BE SOLVED: To provide an image display device preventing generation of discharge and damage on a spacer with improved reliability and display quality.
SOLUTION: A spacer body structure 22 supporting an ambient pressure load acting on a first and a second substrates is provided between the first substrate 10 with a phosphor screen formed and the second substrate 12 fitted with a plurality of electron emission sources 18. The spacer body structure is provided with a support substrate 24 arranged in opposition to the first and the second substrates, equipped with a plurality of electron beam passing holes 26 set in opposition to the respective electron emission sources and coated with an insulating layer 25, as well as a plurality of spacers 30a, 30b erected on at least either surface of the support substrate 24 among the plurality of electron beam passing holes. A peripheral edge part of the support substrate is covered with an insulating member 48 set in superposition on the insulating layer.
COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 要解决的问题：提供一种图像显示装置，其以可靠性和显示质量提高的方式防止间隔物的放电和损坏的产生。 解决方案：支撑作用在第一和第二基板上的环境压力负载的间隔体结构22设置在第一基板10与形成的荧光屏之间，第二基板12装配有多个电子发射源18。 间隔件主体结构设置有与第一和第二基板相对布置的支撑基板24，该基板装备有与各个电子发射源相对设置的多个电子束通过孔26，并且涂覆有绝缘层25，作为 以及竖立在多个电子束通过孔中的支撑基板24的至少任一表面上的多个间隔件30a，30b。 支撑基板的外围边缘部分被叠置在绝缘层上的绝缘构件48覆盖。 版权所有（C）2005，JPO＆NCIPI

公开(公告)号：JP2005100842A

公开(公告)日：2005-04-14

申请号：JP2003333948

申请日：2003-09-25

Applicant: Toshiba Corp ,  株式会社東芝

Inventor： AOYAMA NOBUYUKI ,  NIKAIDO MASARU ,  ISHIKAWA SATOSHI ,  KOYAIZU SATOKO

IPC: H01J9/24 ,  H01J29/87 ,  H01J31/12

Abstract: PROBLEM TO BE SOLVED: To provide an image display device capable of easily controlling an orbit of an electron beam, suppressing discharge to an electron emission source side, and improving reliability and display quality, and to provide its manufacturing method. SOLUTION: A first substrate 10 in which an image display surface is formed and a second substrate 12 in which a plurality of electron emission sources are provided are disposed facing each other. A plurality of spacers 30a, 30b are arranged between the first and second substrates to support atmospheric pressure load acting on the substrates. The spacers are formed out of an insulating material, and a granular conductive material 33 covered with an insulating material is built in an end part of the spacer abutted on the second substrate. COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 解决的问题：提供能够容易地控制电子束的轨道，抑制向电子发射源侧的放电，提高可靠性和显示质量的图像显示装置，并提供其制造方法。 解决方案：其中形成图像显示表面的第一衬底10和设置有多个电子发射源的第二衬底12彼此面对布置。 多个间隔件30a，30b布置在第一和第二基板之间以支撑作用在基板上的大气压力负载。 隔离物由绝缘材料形成，并且覆盖有绝缘材料的颗粒状导电材料33内置在抵靠在第二基板上的间隔件的端部。 版权所有（C）2005，JPO＆NCIPI

公开(公告)号：JP2005093322A

公开(公告)日：2005-04-07

申请号：JP2003327610

申请日：2003-09-19

Applicant: Toshiba Corp ,  株式会社東芝

Inventor： TAKENAKA SHIGEO ,  NIKAIDO MASARU ,  KOYAIZU SATOKO ,  ISHIKAWA SATOSHI

IPC: H01J9/24 ,  H01J29/06 ,  H01J29/87 ,  H01J31/12

Abstract: PROBLEM TO BE SOLVED: To provide an image display device and a manufacturing method therefor, for which the occurrences of deviation of tracks of electron beams and a gap between a spacer and a substrate is suppressed and the reliability and display quality is improved.
SOLUTION: A first substrate 10 with an image display surface formed thereon and a second substrate 12 with a plurality of electron emission sources disposed thereon are arranged facing each other. A plate-like grid 24 is disposed between the first and the second substrates 10, 12. A plurality of first spacers 30a are erected between the grid 24 and the first substrate 10, and a plurality of second spacers 30b are erected between the grid and the second substrate 12. A first conductive layer 68a is provided between the grid and the first spacer 30a, and a second conductive layer 68b is provided between the grid and the second spacer 30b. A conductive part is provided at an end part, on a side of the second substrate 12 of the second spacer 30b.
COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 要解决的问题：提供一种图像显示装置及其制造方法，其中抑制了电子束的轨迹偏移和间隔物与衬底之间的间隙的发生，提高了可靠性和显示质量 。 解决方案：其上形成有图像显示表面的第一基板10和其上布置有多个电子发射源的第二基板12彼此面对布置。 板状栅极24设置在第一和第二基板10,12之间。多个第一间隔件30a竖立在栅格24和第一基板10之间，并且多个第二间隔件30b竖立在格栅和 第二基板12.第一导电层68a设置在栅格和第一间隔物30a之间，第二导电层68b设置在栅格与第二间隔物30b之间。 导电部设置在第二间隔件30b的第二基板12的一侧的端部。 版权所有（C）2005，JPO＆NCIPI

公开(公告)号：JP2004303458A

公开(公告)日：2004-10-28

申请号：JP2003091974

申请日：2003-03-28

Applicant: Toshiba Corp ,  株式会社東芝

Inventor： HIRAHARA SACHIKO ,  NIKAIDO MASARU ,  ISHIKAWA SATOSHI

IPC: H01J29/87 ,  H01J31/12

Abstract: PROBLEM TO BE SOLVED: To provide an image display device, and its manufacturing method, with a track of electron beams easily controlled and discharge toward the side of an electron emission source restrained, and with reliability and display quality improved.
SOLUTION: The device is provided with a first base plate 10 having a phosphor screen, a second base plate arranged in opposition to the first base plate with an interval and fitted with a plurality of electron emission sources 18 for exciting the phosphor screen. A plurality of spacers 30a, 30b are provided between these first and second base plates for supporting an atmospheric pressure load acting on the base plates. Each spacer is divided into a plurality of portions on the way between the first and the second base plates arrayed with gaps, and is provided with a plurality of divided parts 42 in contact with the second base plate.
COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 要解决的问题：提供一种图像显示装置及其制造方法，其中电子束的轨迹容易地被控制并且朝向限制的电子发射源的侧面放电，并且可靠性和显示质量得到改善。 解决方案：该装置设置有具有荧光屏的第一基板10，与间隔布置成与第一基板相对的第二基板，并配有多个用于激发荧光屏的电子发射源18 。 在这些第一和第二基板之间设置有多个间隔件30a，30b，用于支撑作用在基板上的大气压力。 每个间隔件在排列有间隙的第一和第二基板之间的路上被分成多个部分，并且设置有多个与第二基板接触的分开的部分42。 版权所有（C）2005，JPO＆NCIPI

公开(公告)号：JP2004214146A

公开(公告)日：2004-07-29

申请号：JP2003002320

申请日：2003-01-08

Applicant: Toshiba Corp ,  株式会社東芝

Inventor： ISHIKAWA SATOSHI ,  NIKAIDO MASARU

IPC: H01J9/24 ,  H01J9/14 ,  H01J29/06 ,  H01J29/87 ,  H01J31/12

Abstract: PROBLEM TO BE SOLVED: To provide an image display device, and its manufacturing method, with an excellent voltage-withstanding property against discharge and an improved image definition.
SOLUTION: The device is provided with a first substrate 10 having an image display face, a second substrate arranged in opposition to the first substrate with a gap in between and fitted with a plurality of electron sources 18 exciting the image display face. A plurality of spacers 30a, 30b supporting an atmospheric pressure load acting on a plate-shaped grid 24 and the substrate are fitted between the first and the second substrates. At least either surface of the grid 24 is coated with a high-resistance film 40. A softening point of glass forming the spacers is set lower than that of glass forming the high-resistance film.
COPYRIGHT: (C)2004,JPO&NCIPI

Abstract translation: 要解决的问题：提供一种对放电具有优异的耐电压特性和改进的图像定义的图像显示装置及其制造方法。 解决方案：设备设置有具有图像显示面的第一基板10，与第一基板相对布置的第二基板，其间具有间隙，并配合有激励图像显示面的多个电子源18。 支撑作用在板状栅格24上的大气压负荷和基板的多个间隔件30a，30b装配在第一和第二基板之间。 栅格24的至少任一表面涂覆有高电阻膜40.形成间隔物的玻璃的软化点被设定为低于形成高电阻膜的玻璃的软化点。 版权所有（C）2004，JPO＆NCIPI

公开(公告)号：JP2004178912A

公开(公告)日：2004-06-24

申请号：JP2002342507

申请日：2002-11-26

Applicant: Toshiba Corp ,  株式会社東芝

Inventor： SHIMAYAMA KENTARO ,  NIKAIDO MASARU ,  ISHIKAWA SATOSHI

IPC: H01J9/24 ,  H01J29/06 ,  H01J29/87 ,  H01J31/12

Abstract: PROBLEM TO BE SOLVED: To provide a picture display device whose electric discharges along spacers are suppressed and whose atmospheric pressure-proof strength is improved, and also to provide a manufacturing method for a spacer assembly which is used for the picture display device.
SOLUTION: The picture display device is equipped with the first base plate 10 having a phosphor screen, and the second base plate which is disposed in face to face with the first base plate with a gap and on which a plurality of electron sources 18 are arranged. A spacer assembly 22 which supports the atmospheric pressure loading that acts on the first and the second base plates is equipped between these base plates. The spacer assembly has a plate shape grid, a plurality of the first spacers 30a which are built on the first surface of the grid, and a plurality of the second spacers 30b which are built on the second surface of the grid. First base plate side and second base plate side tip surfaces of the first and the second spacers are polished in a planar shape.
COPYRIGHT: (C)2004,JPO

Abstract translation: 要解决的问题：提供一种能够抑制沿隔离物放电的图像显示装置，其耐大气压力强度得到改善，并且还提供了用于图像显示装置的间隔件组件的制造方法 。 解决方案：图像显示装置配备有具有荧光屏的第一基板10，并且第二基板与第一基板面对面设置有间隙，并且多个电子源 18排列。 支撑作用在第一和第二基板上的大气压力负载的间隔件组件22装备在这些基板之间。 间隔件组件具有板状网格，多个第一间隔件30a，其构建在网格的第一表面上，多个第二间隔件30b构建在网格的第二表面上。 将第一和第二间隔物的第一基板侧和第二基板侧端面抛光成平面形状。 版权所有（C）2004，JPO

公开(公告)号：JP2003242909A

公开(公告)日：2003-08-29

申请号：JP2002041877

申请日：2002-02-19

Applicant: TOSHIBA CORP

Inventor： TAKENAKA SHIGEO ,  SHIMAYAMA KENTARO ,  NIKAIDO MASARU ,  ISHIKAWA SATOSHI

IPC: H01J29/87 ,  H01J29/06 ,  H01J31/12

Abstract: PROBLEM TO BE SOLVED: To provide an image display device having an improved image quality by preventing the orbit of electron beam from deviation. SOLUTION: The image display device comprises a face plate 12 having an image display surface, and a rear plate 10 located so as to face the face plate 12 with a gap, on which, a plurality of electron sources 18, exciting the image display surface, is arranged. A plurality of spacers 30a, 30b, keeping the distance between the plates, are arranged between the face plate and the rear plate. Conductive layers 33, repelling the electron beam emitted from the electron sources, are formed to the surface of the end part at the rear plate side of the plurality of spacers. COPYRIGHT: (C)2003,JPO