公开(公告)号：JPH0268122A

公开(公告)日：1990-03-07

申请号：JP22040888

申请日：1988-09-05

Applicant: TOSOH CORP

Inventor： MIYAKI YOSHIYUKI ,  SATOU KIMIYASU ,  KATAOKA TOSHIYA

IPC: B01D61/44

Abstract: PURPOSE:To replace an electrolyte A in specimen liquid with an electrolyte B at high yield by introducing the specimen liquid contg. the electrolyte A and the aimed substance into the specimen chamber of an eleotrodialysis vessel and introducing an aq. soln. contg. the electrolyte B into an anodic chamber and a cathodic chamber and performing electrodialysis. CONSTITUTION:An electrodialysis vessel is constituted of an anodic chamber 1 with an anode 6 arranged therein, a specimen chamber 2 pinched by the ampho-ion exchange membranes 4, 5 having a cation exchange region and an anion exchange region on the double sides of the membranes respectively and a cathodic chamber 3 with a cathode 7 arranged therein. Specimen liquid contg. an electrolyte A (e.g., common salt) and the aimed substance (e.g., lactic dehydrogenase) is introduced into the specimen chamber 2 and an aq. soln. contg. an electrolyte B (e.g., ammonium acetate) is introduced into the anodic chamber 1 and the cathodic chamber 3. Electrodialysis is performed to replace the electrolyte A in the specimen liquid with the electrolyte B. As a result, replacement of the electrolyte in the specimen liquid contg. the aimed substance can be easily and quickly performed at high yield. Furthermore when the aimed substance is biochemical substance, the electrolyte can be replaced without impairing active yield thereof.

公开(公告)号：JPH01151910A

公开(公告)日：1989-06-14

申请号：JP30957487

申请日：1987-12-09

Applicant: TOSOH CORP

Inventor： SATOU KIMIYASU ,  MIYAKI YOSHIYUKI ,  HOSAKO KEIICHI ,  TANAKA NOBUO

IPC: B01D61/46 ,  B01D61/50 ,  B01D61/54 ,  B01D65/10

Abstract: PURPOSE:To safely operate the above dialyzer by providing a liquid spill detector to the inside or the periphery of the electrodialyzer and stopping operation of the equipment at the time of liquid spill. CONSTITUTION:Liquid spill detection sensors 6, 7, 8, 9, 10 are fitted to the insides or the peripheries of feed pumps 1, 2, an electrolyte tank 3, an objective liquid tank 4, an electrodialysis tank 5 and a liquid feed line. When liquid spill is caused, conductivity between the electrodes of the sensors is measured with a conductivity measuring circuit 11. When this measured value reaches some conductivity and below, A/D conversion is performed in an A/D converter 12 and generation of liquid spill is concluded. A command is output to a pump controller 14 by a computer 13 and immediately liquid supply is stopped and liquid spill is indicated on an indication panel and announced with a buzzer 16.

公开(公告)号：JPH03144356A

公开(公告)日：1991-06-19

申请号：JP28180689

申请日：1989-10-31

Applicant: TOSOH CORP

Inventor： KUMAMARU NAOHIRO ,  SATOU KIMIYASU ,  MIYAKI YOSHIYUKI ,  MATSUSHITA SHUN

IPC: G01N21/73 ,  G01N21/27 ,  G01N21/31 ,  G01N27/26 ,  G01N30/02 ,  G01N30/06 ,  G01N30/14

Abstract: PURPOSE:To achieve an accurate analysis of cations existing in a reagent in a strong acid by using an electric dialyzer with an anode chamber, a cathode chamber and a sample chamber to perform a neutrization by electric dialysis. CONSTITUTION:As an electric dialyzer is energized electrically, hydroxide ions in a cathode chamber 3 move to a sample chamber 2 passing through an anion exchange membrane 5. On the other hand, anions contained in a sample liquid move to an anode chamber 1 passing through an anion exchange membrane 4 from the sample chamber 2. Therefore, the anions existing originally in the sample liquid is replaced with the hydroxide ions being supplied from the cathode chamber 3 with elapse of time. Thus, the sample liquid is neutralized. At this point, when arranged at optional positions of a feed liquid line 12, an ion sensor, an electric conductivity detector or a pH meter allows the monitoring of neutral condition in the sample liquid simultaneously with the start of operation.

公开(公告)号：JPH01147179A

公开(公告)日：1989-06-08

申请号：JP30151987

申请日：1987-12-01

Applicant: TOSOH CORP

Inventor： SATOU KIMIYASU ,  MIYAKI YOSHIYUKI ,  HOSAKO KEIICHI

IPC: F04C5/00

Abstract: PURPOSE:To enable a roller pump to be used more safely and comfortably by installing, on the roller pump, a liquid leakage detecting sensor formed with at least a pair of electrodes. CONSTITUTION:A roller pump comprises a liquid leakage detector 2, a circuit 2 for measuring conductivity, a circuit 4 for detecting liquid leakage by existent conductivity and further controlling a liquid leakage alarm, its display and the operation of the roller pump, an alarm device 5 for informing the liquid leakage and a display device for informing the liquid leakage. When liquid leaks, the operation is stopped immediately by detecting the leakage, and leak age is displayed, and then liquid leakage is informed by a noise. Thereby, it is possible to reduce the loss of liquid.

公开(公告)号：JPH0263527A

公开(公告)日：1990-03-02

申请号：JP21358688

申请日：1988-08-30

Applicant: TOSOH CORP

Inventor： SATOU KIMIYASU ,  MIYAKI YOSHIYUKI

IPC: A23L5/20 ,  B01D61/44 ,  B01D61/58 ,  C07C227/18 ,  C07K1/14 ,  C07K1/16 ,  C07K1/34 ,  C07K1/36 ,  C07K5/08 ,  C07K14/575 ,  C07K16/00

Abstract: PURPOSE:To carry out desalting of a biochemical substance with high rate of recovery and high activity yield by desalting the material to a low concn. by the electrodialytic method using an ion exchange membrane, desalting then by the dialytic method with a diffusion dialysis membrane or an amphoteric ion exchange membrane. CONSTITUTION:After desalting a biochemical substance to a low concn. by the electrodialysis using an ion exchange membrane, the biochemical substance is desalted further by changing the method to a dialytic method using a diffusion dialysis membrane or an amphoteric ion exchange membrane, or a precision filtration method using a precision filtration membrane, ultrafiltration method or gel filtration method using an ultrafiltration membrane. Concrete examples for the biochemical substance as the object of desalting are, amino acids, oligopeptides, antibiotics, extracts from living bodies, enzymes, antigens, etc. Suitable current density for electrodialysis is 0.2-50A/dm , and suitable concn. to be attained by the desalting by the electrodialysis is 0.001-1M.

公开(公告)号：JPH01123606A

公开(公告)日：1989-05-16

申请号：JP27823787

申请日：1987-11-05

Applicant: TOSOH CORP

Inventor： SATOU KIMIYASU ,  KURAUCHI YASUHIRO ,  MIYAKI YOSHIYUKI ,  AKAZAWA MICHIHIRO

IPC: C01B7/19 ,  B01D61/44 ,  B01D61/50 ,  C02F1/46 ,  C02F1/469

Abstract: PURPOSE:To prevent corrosion of an anode and a cathode by hydrofluoric acid by protecting the electrodes from hydrofluoric acid by a cation-exchange membrane at the time of recovering hydrofluoric acid by electrodialysis. CONSTITUTION:An anion-exchange membrane 8 is placed between the cation- exchange membranes 9, the anode 6 and cathode are arranged on the outside of the cation-exchange membranes 9, and the anode chamber 4, cathode chamber 5, supply liq. chamber 2, and recovered liq. chamber 3 are separated from each other. An aq. sulfuric acid soln. is charged in the anode chamber 4 and cathode chamber 5, an aq. hydrofluoric acid soln. is charged in the recovered liq. chamber 3, the hydrofluoric acid contg. an iron ion and a nickel ion is circulated through the supply liq. chamber 2, and electrodialysis is carried out. Since the electrodes are protected from the hydrofluoric acid by the anion-exchange membrane, the corrosion of the anode as well as of the cathode by the hydrofluoric acid can be prevented, and hydrofluoric acid can be efficiently recovered.

公开(公告)号：JPH038418A

公开(公告)日：1991-01-16

申请号：JP14297989

申请日：1989-06-07

Applicant: TOSOH CORP

Inventor： MIYAKI YOSHIYUKI ,  SATOU KIMIYASU

IPC: B01D61/44

Abstract: PURPOSE:To easily substitute the electrolyte in a sample liquid by putting the sample liquid into the sample chamber of an electrodialysis cell consisting of an anode chamber, the sample chamber held in place by two sheets of microporous membranes and a cathode chamber, putting an aq. soln. into the anode chamber and the cathode chamber and passing current to the electrodialysis cell. CONSTITUTION:The electrodialysis cell is constituted of the anode chamber 1 disposed with an anode 6, the sample chamber 2 held in place between two sheets of the microporous membranes 4, 5 and the cathode chamber 3 disposed with a cathode 7. The sample liquid contg. the sample and the electrolyte A is put into the sample chamber 2 of such electrodialysis cell and the aq. soln. of the electrolyte B is put into the anode chamber 1 and the cathode chamber 3. The electricity is then passed to the electrodialysis cell. As a result, the electrolyte A in the sample liquid is easily and rapidly substd. with the electrolyte B without changing the properties of the sample. This method is applicable to pretreatments for various analyses associated with biochemical materials from low to high mol.wt. (e.g. protein, enzyme, antibodies, oligopeptide, materials associated with nucleic acids, polysaccharides, antibiotics, etc.) or the separating and refining thereof, etc.

公开(公告)号：JPH01203952A

公开(公告)日：1989-08-16

申请号：JP2988688

申请日：1988-02-10

Applicant: TOSOH CORP ,  PERMELEC ELECTRODE LTD

Inventor： SATOU KIMIYASU ,  MIYAKI YOSHIYUKI ,  HIRAO KAZUHIRO ,  MATSUMOTO YUKIE

IPC: G01R27/22 ,  G01N27/07

Abstract: PURPOSE:To provide an electric conductivity meter which is stable and is highly resistant to corrosion and to obtain a good linear relation between the conductivity between electrodes to be measured and an actual salt concn. by incorporating at least any one noble metal oxide among Pt, Ir, Os, Pd, Ru and Rh on the surface of the base bodies of the metallic electrodes. CONSTITUTION:At least one or two noble metal oxides are incorporated into the coating layer of a conductive metal oxide which coats the surface of electrode base bodies to be used for the electrodes. The coating layer which contains >=1 among the oxides of Ti, Ta, Nb, Zr, Hf, Al, Si, Sn, Sb, and Bi as the metal oxide except noble metals is equally satisfactory. for example, an electrode cell consisting of a pair of the electrodes 1, 1, an intermediate chamber spacer 2, and cell frames 3, 3 is formed. The electrodes formed by coating TiO2 doped with 30mol.% RuO2 on the surface of the Ti electrode base bodies to 10mum thickness are used. The electrical conductivity meter which is stable and is highly resistant to corrosion is thereby obtd. and the god linear relation between the conductivity between the electrodes to be measured and the actual salt concn. is thereby obtd.

公开(公告)号：JPS6480408A

公开(公告)日：1989-03-27

申请号：JP23708987

申请日：1987-09-24

Applicant: TOSOH CORP

Inventor： MIYAKI YOSHIYUKI ,  TABATA TOMOKAZU ,  KATAOKA TOSHIYA ,  SATOU KIMIYASU

IPC: G01N27/26 ,  B01D61/52

Abstract: PURPOSE:To enhance selectivity of separation of metal ions by a simple and convenient method by forming a complex of a specified metal ion by adding a chelating agent to a treating liquid and inhibiting the permeation of the ion through a membrane. CONSTITUTION:An electrodialytic cell 1 constituted of an anion exchange membrane 5, cation exchange membrane 6, anode 7, and cathode 8, is used, and a chelating agent such as ethylenediamine tetraacetate, etc., is added to a soln. contg., for example, Na , Fe , Ca as a sample liquid. In this stage, the pH of the soln. is adjusted to a condition where the metal to be separated forms a complex depending on an equilibrium constant for the formation of the metal complex. The sample liquid is circulated through an intermediate chamber 2, and electrodialysis is performed by circulating the electrode liquid through the cathode chamber 4 and the anode chamber 3. Thus, Na and Ca permeate the membrane selectively, and are removed from the initial sample liquid.

公开(公告)号：JPS6480407A

公开(公告)日：1989-03-27

申请号：JP23632987

申请日：1987-09-22

Applicant: TOSOH CORP

Inventor： MIYAKI YOSHIYUKI ,  SATOU KIMIYASU ,  FUJII KAZUMASA ,  TANAKA NOBUO

IPC: B01D61/46

Abstract: PURPOSE:To permit convenient desalting of an aq. soln. contg. biochemical substances, etc., by incorporating an electroconductivity measuring cell into the feed line of the object liquid and monitoring the degree of progress of desalting during desalting operation. CONSTITUTION:Object liquid such as soln. of amino acid, oligopeptide, etc., is supplied from an object liquid tank 10 to a desalting chamber 2 for the object liquid laid between an anion exchange membrane 5 and a cation exchange membrane 6 with a liquid feed pump 15 through an electroconductivity measuring cell 16, and the liquid is circulated further through a feed line 12 of the object liquid to the object liquid tank 10. On one hand, electrode liquid is fed to an anode chamber 3 and a cathode chamber 4 from an electrode liquid tank 11 with a liquid feed pump 14, and circulated to the electrode liquid tank 11 through an electrode liquid feed line 13. The degree of progress of desalting is monitored by connecting the electrodes of the electroconductivity measuring cell 16 to a conductivity meter and by measuring the electroconductivity of the object liquid.