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    Fc-BINDING PROTEIN, METHOD FOR PRODUCING SAID PROTEIN, AND ANTIBODY ADSORBENT USING SAID PROTEIN, AND METHODS FOR PURIFYING AND IDENTIFYING ANTIBODY USING SAID ADSORBENT
    4.
    发明公开
    Fc-BINDING PROTEIN, METHOD FOR PRODUCING SAID PROTEIN, AND ANTIBODY ADSORBENT USING SAID PROTEIN, AND METHODS FOR PURIFYING AND IDENTIFYING ANTIBODY USING SAID ADSORBENT 审中-公开
    FC-BINDENDES PROTEIN，VERFAHREN ZUR HERSTELLUNG DAVON UNDANTIKÖRPERADSORPTIONSMITTEL麻省理工学院DIESEM蛋白质研究中心ZUR REINIGUNG UND IDENTIFIZIERUNG DES抗菌剂UNTER VERWENDUNG DIESES ADSORPTIONSMITTELS

    公开(公告)号：EP3048112A4

    公开(公告)日：2017-07-26

    申请号：EP14846295

    申请日：2014-09-18

    Applicant: TOSOH CORP

    Inventor： ASAOKA YOSHIHARU ,  TANAKA TORU ,  IDE TERUHIKO

    IPC: C07K14/735 ,  C07H1/06 ,  C07K1/22 ,  C12N1/21 ,  C12N15/09 ,  C12P21/02

    CPC classification number: C07K14/70535 ,  C07H1/06 ,  C07K1/22 ,  C07K16/283 ,  C07K17/00 ,  C07K2317/10 ,  C07K2317/732

    Abstract: The present invention addresses the first problem of providing an Fc-binding protein having improved stability, especially stability to heat and acid, of the Fc-binding protein, a method for producing this protein, and an antibody adsorbent using this protein. The present invention also addresses the second problem of providing a method that makes it possible to identify the presence or absence of glycosylation of an antibody, and a material to be used in this method. The first problem is solved by an Fc-binding protein having improved stability to heat and acid obtained by substituting amino acid residues at specific positions in the extracellular domain within human Fc³RIIIa with other specific amino acids, a method for producing this protein, and an antibody adsorbent using this protein. The second problem is solved by using an adsorbent capable of specifically adsorbing an antibody having a sugar chain, the adsorbent being obtained by immobilizing human Fc³RIIIa on an insoluble carrier.

    Abstract translation: 本发明解决了提供具有提高的Fc结合蛋白的稳定性，特别是热和酸的稳定性的Fc结合蛋白的第一个问题，产生该蛋白的方法和使用该蛋白的抗体吸附剂。 本发明还解决了提供一种方法的第二个问题，该方法可以鉴定抗体的糖基化的存在或不存在，以及该方法中使用的材料。 第一个问题可以通过一种Fc结合蛋白来解决，该Fc结合蛋白具有改善的对热和酸的稳定性，通过用其他特定氨基酸取代人FcrRIIIa胞外结构域的特定位置处的氨基酸残基而获得，其制备方法和抗体 使用这种蛋白质的吸附剂。 通过使用能够特异性地吸附具有糖链的抗体的吸附剂解决了第二个问题，所述吸附剂通过将人FcRIIIa固定在不溶性载体上而获得。

    8.
    发明专利
    未知

    公开(公告)号：NO20081834L

    公开(公告)日：2008-05-29

    申请号：NO20081834

    申请日：2008-04-16

    Applicant: TOSOH CORP

    Inventor： TANAKA TORU ,  IDE TERUHIKO

    IPC: C12N1/20 ,  C12N15/01 ,  C12N15/53 ,  C12P23/00 ,  C12R1/01

    Abstract: [Object] To provide a canthaxanthin selective producing bacterium being able to easily extract and purify canthaxanthin, which is one of carotenoids, and a method for producing canthaxanthin by a culture method. [Solving Means] A carotenoid producing bacterium belonging to the genus Paracoccus is provided which selectively produces canthaxanthin so that the amount thereof is not less than 90 percent by weight of the total amount of produced carotenoids including ²-carotene, ²-cryptoxanthin, echinenone, canthaxanthin, 3-hydroxyechinenone, 3'-hydroxyechinenone, zeaxanthin, phoenicoxanthin, adonixanthin, and astaxanthin. In addition, a method for producing canthaxanthin is provided which has the steps of culturing the above bacterium, and then collecting carotenoids from bacterial cells or a culture solution after the culturing.

    NOVEL MICROORGANISM AND METHOD FOR PRODUCING CAROTENOID USING THE SAME
    9.
    发明专利
    NOVEL MICROORGANISM AND METHOD FOR PRODUCING CAROTENOID USING THE SAME 未知

    公开(公告)号：CA2630780A1

    公开(公告)日：2007-06-14

    申请号：CA2630780

    申请日：2006-10-19

    Applicant: TOSOH CORP

    Inventor： IDE TERUHIKO ,  TANAKA TORU

    IPC: C12N1/20 ,  C12N1/21 ,  C12P23/00

    Abstract: It is intended to provide a bacterium selectively synthesizing canthaxanthin from which canthaxanthin, which is a carotenoid, can be simply extracted and purified and a method for producing canthaxanthin by a culture method. A carotenoid-producing bacterium belonging to the genus Paracoccus which selectively produces canthaxanthin which accounts for 90% by weight or more of the total amount of produced carotenoids which include .beta.-carotene, .bet a.- cryptoxanthin, echinenone, canthaxanthin, 3-hydroxyechinenone, 3~- hydroxyechinenone, zeaxanthin, phoenicoxanthin, adonixanthin and astaxanthin , and a method for producing canthaxanthin in which a cultivation is carried o ut using the bacterium and the carotenoids are collected from the bacterial cel l or the culture solution after the cultivation.

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