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    METHOD FOR ISOLATING SALT OF PYRUVIC ACID DERIVATIVE
    6.
    发明专利
    METHOD FOR ISOLATING SALT OF PYRUVIC ACID DERIVATIVE 失效

    公开(公告)号：JP2001220361A

    公开(公告)日：2001-08-14

    申请号：JP2000032770

    申请日：2000-02-04

    Applicant: TOSOH CORP

    Inventor： KONO KAZUHISA ,  TOKUHISA KENJI ,  KAKIYA HITOSHI ,  HANZAWA SATOSHI ,  OE MASATAKE

    IPC: C07C51/43 ,  C07C51/487 ,  C07C59/84

    Abstract: PROBLEM TO BE SOLVED: To provide a method for readily and inexpensively isolating a salt of a pyruvic acid derivative difficult to be taken out and dissolved in a solution, in good purity in a short time at a low cost. SOLUTION: Another salt or an acid, not reacting with a compound represented by general formula [I] and having higher solubility in water is added to a solution including the salt of the pyruvic acid derivative (e.g. sodium 2-naphthylpyruvate) represented by general formula [1] to precipitate and recover the compound represented by the general formula [I].

    DITERPENE DERIVATIVE, ITS PRODUCTION AND ANTITUMOR AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT
    8.
    发明专利
    DITERPENE DERIVATIVE, ITS PRODUCTION AND ANTITUMOR AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT 失效

    公开(公告)号：JPH08245505A

    公开(公告)日：1996-09-24

    申请号：JP22896595

    申请日：1995-09-06

    Applicant: TOSOH CORP ,  SAGAMI CHEM RES

    Inventor： KAMIMURA DAISUKE ,  YAMADA KAORU ,  TOKUHISA KENJI ,  WATANABE HIROYUKI

    IPC: A61K31/215 ,  A61P35/00 ,  C07C67/14 ,  C07C67/28 ,  C07C69/33 ,  C07C271/34

    Abstract: PURPOSE: To obtain a new compound useful as physiologically active substances including technical products of medicines and agrochemicals, their intermediates and antitumor agents. CONSTITUTION: This compound of formula I [R is H or a 1-20C acyloxy; R and R are each H or pivalyl and R and R are each H when R is H, on the other hand, R and R are each H, a 1-20C acyl, a (substituted)benzoyl, a (substituted)benzyl, trityl, etc., when A is the 1-20C acyloxy], e.g. 1,3- oxyingenol 20-trityl ether. The compound of formula I is obtained by reacting a compound of formula II [R is H or a 1-20C acyloxy; R is pivalyl when R is H, on the other hand, R is a 1-20C acyl, a (substituted)benzoyl, a (substituted)benzyl, trityl, etc., when R is a 1-20C acyloxy] with a halide of the formula R X [R is a 1-20C acyl, a (substituted)benzoyl, a (substituted) benzyl, trityl, etc.; X is a halogen].

    Method for producing l-thiazolylalanine
    10.
    发明专利
    Method for producing l-thiazolylalanine 审中-公开
    生产L-三唑基亚胺的方法

    公开(公告)号：JP2003081950A

    公开(公告)日：2003-03-19

    申请号：JP2001276482

    申请日：2001-09-12

    Applicant: Tosoh Corp ,  東ソー株式会社

    Inventor： KONO KAZUHISA ,  TOKUHISA KENJI ,  KAKIYA HITOSHI ,  HANZAWA SATOSHI ,  OE MASATAKE

    IPC: C12N15/09 ,  C07D277/20 ,  C07D277/30 ,  C07D417/06 ,  C12P13/02

    Abstract: PROBLEM TO BE SOLVED: To provide a method comprising producing 5-(thiazolylmethylene) hydantoin which is a new compound obtained from thiazole-aldehyde and hydantoin, producing 2-hydroxy-3-thiazolylacrylic acid and/or a salt thereof, and further producing L-thyazolylalanine by using the compound as a raw material.
    SOLUTION: This method for producing the L-thyazolylalanine comprises reacting the thiazole-aldehyde with the hydantoin in the presence of 2- aminoethanol to provide the 5-(thiazolylmethylene)hydantoin, hydrolyzing the produced 5-(thiazolylmethylene)hydantoin in the presence of a base to provide the 2-hydroxy-3-thiazolylacrylic acid and/or the salt thereof, and subjecting the obtained 2-hydroxy-3-thiazolylacrylic acid and/or the salt thereof to an amino group-transfer reaction from a natural amino acid by using an enzyme.
    COPYRIGHT: (C)2003,JPO

    Abstract translation: 要解决的问题：提供一种制备5-噻唑基亚甲基乙内酰脲的方法，该方法是从噻唑醛和乙内酰脲获得的新化合物，产生2-羟基-3-噻唑基丙烯酸和/或其盐，并进一步制备L 通过使用该化合物作为原料。 解决方案：该制备L-甲硫基丙氨酸的方法包括在2-氨基乙醇存在下使噻唑醛与乙内酰脲反应，得到5-（噻唑基亚甲基）乙内酰脲，在生成5-（噻唑基亚甲基）乙内酰脲的条件下， 得到2-羟基-3-噻唑基丙烯酸和/或其盐，并将得到的2-羟基-3-噻唑基丙烯酸和/或其盐从天然氨基酸经氨基转移反应 使用酶。

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