公开(公告)号：WO2023083900A1

公开(公告)日：2023-05-19

申请号：PCT/EP2022/081345

申请日：2022-11-09

Applicant: TUBULIS GMBH ,  FORSCHUNGSVERBUND BERLIN E.V.

Inventor： HACKENBERGER, Christian ,  OCHTROP, Philipp ,  JAHZERAH, Jahaziel ,  MACHUI, Paul ,  SCHUMACHER, Dominik ,  HELMA-SMETS, Jonas ,  MAI, Isabelle ,  KASPER, Marc-André

IPC: A61K47/68

Abstract: The present invention relates to a conjugate having the formula (I): wherein a receptor binding molecule (RBM) is connected with a drug moiety (D). The present invention also relates to intermediates for producing the same, methods of preparing the same, pharmaceutical compositions comprising the same, as well as uses thereof.

公开(公告)号：EP4429708A1

公开(公告)日：2024-09-18

申请号：EP22817174.0

申请日：2022-11-09

Applicant: Tubulis GmbH ,  Forschungsverbund Berlin E.V.

Inventor： HACKENBERGER, Christian ,  OCHTROP, Philipp ,  JAHZERAH, Jahaziel ,  MACHUI, Paul ,  SCHUMACHER, Dominik ,  HELMA-SMETS, Jonas ,  MAI, Isabelle ,  KASPER, Marc-André

IPC: A61K47/68

CPC classification number: A61K47/6889 ,  A61K47/6809

公开(公告)号：WO2023083919A1

公开(公告)日：2023-05-19

申请号：PCT/EP2022/081371

申请日：2022-11-09

Applicant: TUBULIS GMBH

Inventor： KASPER, Marc-André ,  MACHUI, Paul ,  MAI, Isabelle ,  VOGL, Annette ,  SCHMITT, Saskia ,  SCHUMACHER, Dominik ,  HELMA-SMETS, Jonas

IPC: A61K47/68

Abstract: The present invention relates to a conjugate having the formula (I) wherein a receptor binding molecule (RBM) is connected with a camptothecin moiety (C). The present invention also relates to intermediates for producing the same, methods of preparing the same, pharmaceutical compositions comprising the same, as well as uses thereof.

公开(公告)号：EP4429709A1

公开(公告)日：2024-09-18

申请号：EP22817180.7

申请日：2022-11-09

Applicant: Tubulis GmbH

Inventor： KASPER, Marc-André ,  MACHUI, Paul ,  MAI, Isabelle ,  VOGL, Annette ,  SCHMITT, Saskia ,  SCHUMACHER, Dominik ,  HELMA-SMETS, Jonas

IPC: A61K47/68

CPC classification number: A61K47/6809 ,  A61K47/6889 ,  A61K47/68037