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公开(公告)号：US20210163586A1
公开(公告)日：2021-06-03
申请号：US17172109
申请日：2021-02-10
Applicant: UCB BIOPHARMA SRL
Inventor： NEESHA DEDI , BREDA TWOMEY , MICHAEL JOHN WRIGHT , GARETH DAVIES , DAVID JAMES MCMILLAN
Abstract: This invention relates to crystals of the human Gremlin-1 protein, and the human Gremlin-1 protein in complex with an inhibitory antibody. The invention also relates to the structure of human Gremlin-1 (on its own, or in complex with the antibody) and uses of these structures in screening for agents which modulate Gremlin-1 activity. The invention further provides antibodies which bind an allosteric inhibitory site on Gremlin-1, together with pharmaceutical compositions and medical uses of such antibodies and agents identified by the screening methods.
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公开(公告)号：US20240076365A1
公开(公告)日：2024-03-07
申请号：US18502188
申请日：2023-11-06
Applicant: UCB BIOPHARMA SRL
Inventor： NEESHA DEDI , BREDA TWOMEY , MICHAEL JOHN WRIGHT , GARETH CHARLES GLYNDWR DAVIES , DAVID JAMES MCMILLAN
CPC classification number: C07K16/22 , A61P9/12 , C07K14/51 , G01N33/6854 , A61K2039/505
Abstract: This invention relates to crystals of the human Gremlin-1 protein, and the human Gremlin-1 protein in complex with an inhibitory antibody. The invention also relates to the structure of human Gremlin-1 (on its own, or in complex with the antibody) and uses of these structures in screening for agents which modulate Gremlin-1 activity. The invention further provides antibodies which bind an allosteric inhibitory site on Gremlin-1, together with pharmaceutical compositions and medical uses of such antibodies and agents identified by the screening methods.
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