公开(公告)号：US20210163586A1

公开(公告)日：2021-06-03

申请号：US17172109

申请日：2021-02-10

Applicant: UCB BIOPHARMA SRL

Inventor： NEESHA DEDI ,  BREDA TWOMEY ,  MICHAEL JOHN WRIGHT ,  GARETH DAVIES ,  DAVID JAMES MCMILLAN

IPC: C07K16/22 ,  A61P9/12 ,  C07K14/51 ,  G01N33/68

Abstract: This invention relates to crystals of the human Gremlin-1 protein, and the human Gremlin-1 protein in complex with an inhibitory antibody. The invention also relates to the structure of human Gremlin-1 (on its own, or in complex with the antibody) and uses of these structures in screening for agents which modulate Gremlin-1 activity. The invention further provides antibodies which bind an allosteric inhibitory site on Gremlin-1, together with pharmaceutical compositions and medical uses of such antibodies and agents identified by the screening methods.