公开(公告)号：US20210139574A1

公开(公告)日：2021-05-13

申请号：US17136440

申请日：2020-12-29

Applicant: UCB BIOPHARMA SRL

Inventor： KERRY LOUISE TYSON ,  TERENCE SEWARD BAKER ,  GEORGES MAIRET-COELLO ,  PATRICK DOWNEY ,  JEAN-PHILIPPE COURADE ,  DAVID EDWARD ORMONDE KNIGHT

IPC: C07K16/18 ,  A61P25/28 ,  C07K14/47 ,  G01N33/68

Abstract: The present invention relates to Tau-binding antibodies and binding fragments thereof.

公开(公告)号：US20230416350A1

公开(公告)日：2023-12-28

申请号：US18344945

申请日：2023-06-30

Applicant: UCB BIOPHARMA SRL

Inventor： DAVID EDWARD ORMONDE KNIGHT ,  TERENCE SEWARD BAKER ,  DAVID JAMES MCMILLAN ,  ROBERT ANTHONY GRIFFIN ,  GEORGES MAIRET-COELLO ,  PATRICK DOWNEY ,  JEAN-PHILIPPE COURADE

IPC: C07K16/18 ,  C07K14/47 ,  A61P25/28

CPC classification number: C07K16/18 ,  C07K14/4711 ,  A61P25/28 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/56 ,  C07K2317/70

Abstract: The present invention relates to Tau-binding antibodies and binding fragments thereof.

公开(公告)号：US20230331833A1

公开(公告)日：2023-10-19

申请号：US18344930

申请日：2023-06-30

Applicant: UCB BIOPHARMA SRL

Inventor： KERRY LOUISE TYSON ,  TERENCE SEWARD BAKER ,  GEORGES MAIRET-COELLO ,  PATRICK DOWNEY ,  JEAN-PHILIPPE COURADE ,  DAVID EDWARD ORMONDE KNIGHT

IPC: C07K16/18 ,  C07K14/47 ,  A61P25/28 ,  G01N33/68

CPC classification number: C07K16/18 ,  C07K14/4711 ,  A61P25/28 ,  G01N33/6896 ,  A61K2039/505

Abstract: The present invention relates to Tau-binding antibodies and binding fragments thereof.

公开(公告)号：US20210115121A1

公开(公告)日：2021-04-22

申请号：US17136189

申请日：2020-12-29

Applicant: UCB BIOPHARMA SRL

Inventor： DAVID EDWARD ORMONDE KNIGHT ,  TERENCE SEWARD BAKER ,  DAVID JAMES MCMILLAN ,  ROBERT ANTHONY GRIFFIN ,  GEORGES MAIRET-COELLO ,  PATRICK DOWNEY ,  JEAN-PHILIPPE COURADE

IPC: C07K16/18 ,  A61P25/28 ,  C07K14/47

Abstract: The present invention relates to Tau-binding antibodies and binding fragments thereof.

公开(公告)号：BR112020010504A2

公开(公告)日：2020-11-24

申请号：BR112020010504

申请日：2018-12-13

Applicant: UCB BIOPHARMA SRL

Inventor： DANIEL JOHN LIGHTWOOD ,  DAVID JAMES MCMILLAN ,  KERRY LOUISE TYSON ,  LORENZO DE LICHTERVELDE ,  PATRICK DOWNEY ,  RALPH ADAMS ,  TERENCE SEWARD BAKER

IPC: C07K16/18

Abstract: a presente invenção se refere a anticorpos que se ligam à alfa-sinucleína e fragmentos dos mesmos capazes de se ligar à alfa-sinucleína como monômero e em fibrilas e impedem a agregação de alfa-sinucleína induzida por fibrilas de alfa-sinucleína. os anticorpos da presente invenção são para uso no tratamento de alfa-sinucleinopatias, incluindo a doença de parkinson.

公开(公告)号：BR112020010508A2

公开(公告)日：2020-11-24

申请号：BR112020010508

申请日：2018-12-13

Applicant: UCB BIOPHARMA SRL

Inventor： DANIEL JOHN LIGHTWOOD ,  DAVID JAMES MCMILLAN ,  KERRY LOUISE TYSON ,  LORENZO DE LICHTERVELDE ,  MARCO KRIEK ,  PATRICK DOWNEY ,  PETER CHARLES ELLIOTT ,  TERENCE SEWARD BAKER

IPC: A61K39/395 ,  A61K39/00 ,  A61P25/16 ,  A61P25/28 ,  C07K16/28

Abstract: a presente invenção se refere a anticorpos de ligação à alfa-sinucleína e fragmentos dos mesmos, capazes de se ligarem à alfa-sinucleína como um monômero e em fibrilas e previnem a agregação de alfa-sinucleína induzida por fibrilas de alfa-sinucleína. os anticorpos da presente invenção são para uso no tratamento de alfa-sinucleinopatias, incluindo a doença de parkinson.

公开(公告)号：ZA202003414B

公开(公告)日：2022-03-30

申请号：ZA202003414

申请日：2020-06-08

Applicant: UCB BIOPHARMA SRL

Inventor： PATRICK DOWNEY ,  KERRY LOUISE TYSON ,  MARCO KRIEK ,  LORENZO DE LICHTERVELDE ,  DANIEL JOHN LIGHTWOOD ,  DAVID JAMES MCMILLAN ,  PETER CHARLES ELLIOTT ,  TERENCE SEWARD BAKER

Abstract: The present invention relates to alpha synuclein binding antibodies and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.