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公开(公告)号：US20230331833A1
公开(公告)日：2023-10-19
申请号：US18344930
申请日：2023-06-30
Applicant: UCB BIOPHARMA SRL
Inventor： KERRY LOUISE TYSON , TERENCE SEWARD BAKER , GEORGES MAIRET-COELLO , PATRICK DOWNEY , JEAN-PHILIPPE COURADE , DAVID EDWARD ORMONDE KNIGHT
CPC classification number: C07K16/18 , C07K14/4711 , A61P25/28 , G01N33/6896 , A61K2039/505
Abstract: The present invention relates to Tau-binding antibodies and binding fragments thereof.
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公开(公告)号：US20250026836A1
公开(公告)日：2025-01-23
申请号：US18684711
申请日：2022-08-19
Applicant: UCB BIOPHARMA SRL
Inventor： CAROLINE BERTEAU , THOMAS COLLEY , NEESHA DEDI , CARL BRENDAN DOYLE , DAVID PAUL HUMPHREYS , GAELLE LE FRIEC , RUTH MCELHONE , VICTORIA O'DOWD , CLARE THOMPSON , KERRY LOUISE TYSON , ANN LOUISE WHITE
IPC: C07K16/28
Abstract: The present invention relates to antibodies directed against HLA-G and formulations comprising the same. The invention further relates to the use of the HLA-G antibodies and formulations in therapy, notably in the treatment of solid tumors.
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公开(公告)号：US20230135399A1
公开(公告)日：2023-05-04
申请号：US17930074
申请日：2022-09-07
Applicant: UCB BIOPHARMA SRL , BIOGEN MA INC.
Inventor： LINDA C. BURKLY , JANINE L. FERRANT-ORGETTAS , ELLEN A. GARBER , YEN-MING HSU , LIHE SU , FREDERICK R. TAYLOR , RALPH ADAMS , DEREK THOMAS BROWN , ANDREW GEORGE POPPLEWELL , MARTYN KIM ROBINSON , ANTHONY SHOCK , KERRY LOUISE TYSON
IPC: C07K16/28 , A61K39/395 , A61K45/06
Abstract: This invention provides binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind a CD154 (CD4OL) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivative or antibody fragment that specifically binds to an epitope to which a humanized Fab fragment comprising a variable heavy chain sequence according to SEQ ID NO: 1 and comprising a variable light chain sequence according to SEQ ID NO: 2 specifically binds. CD154 binding proteins of this invention may elicit reduced effector function relative to a second anti-CD154 antibody. CD154 binding proteins of this invention are useful in diagnostic and therapeutic methods, such as in the treatment and prevention of diseases including those that involve undesirable immune responses that are mediated by CD154-CD40 interactions.
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公开(公告)号：US20210139574A1
公开(公告)日：2021-05-13
申请号：US17136440
申请日：2020-12-29
Applicant: UCB BIOPHARMA SRL
Inventor： KERRY LOUISE TYSON , TERENCE SEWARD BAKER , GEORGES MAIRET-COELLO , PATRICK DOWNEY , JEAN-PHILIPPE COURADE , DAVID EDWARD ORMONDE KNIGHT
Abstract: The present invention relates to Tau-binding antibodies and binding fragments thereof.
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公开(公告)号：BR112020010504A2
公开(公告)日：2020-11-24
申请号：BR112020010504
申请日：2018-12-13
Applicant: UCB BIOPHARMA SRL
Inventor： DANIEL JOHN LIGHTWOOD , DAVID JAMES MCMILLAN , KERRY LOUISE TYSON , LORENZO DE LICHTERVELDE , PATRICK DOWNEY , RALPH ADAMS , TERENCE SEWARD BAKER
IPC: C07K16/18
Abstract: a presente invenção se refere a anticorpos que se ligam à alfa-sinucleína e fragmentos dos mesmos capazes de se ligar à alfa-sinucleína como monômero e em fibrilas e impedem a agregação de alfa-sinucleína induzida por fibrilas de alfa-sinucleína. os anticorpos da presente invenção são para uso no tratamento de alfa-sinucleinopatias, incluindo a doença de parkinson.
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Patent Agency Ranking
公开(公告)号：BR112022015279A2
公开(公告)日：2022-09-20
申请号：BR112022015279
申请日：2021-02-01
Applicant: UCB BIOPHARMA SRL
Inventor： NEESHA DEDI , PETER CHARLES ELLIOTT , SEPPE FRANS ROMAN LEYSEN , SEAN MASON , DAVID JAMES MCMILLAN , GILLIAN CLAIRE NESS , NICCOLO PENGO , MARTIN ANTHONY REDHEAD , ALISON TURNER , KERRY LOUISE TYSON
Abstract: ANTICORPOS CONTRA KLK5. A presente invenção se refere a anticorpos que ligam e inibem KLK5 e métodos de usar os mesmos para tratar doenças causadas pelo desequilíbrio de KLK5. Em particular, a presente invenção se refere a anticorpos inibidores da ligação de KLK5 e seu uso no tratamento da doença de Netherton, dermatite atópica e câncer.
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公开(公告)号：ZA202003414B
公开(公告)日：2022-03-30
申请号：ZA202003414
申请日：2020-06-08
Applicant: UCB BIOPHARMA SRL
Inventor： PATRICK DOWNEY , KERRY LOUISE TYSON , MARCO KRIEK , LORENZO DE LICHTERVELDE , DANIEL JOHN LIGHTWOOD , DAVID JAMES MCMILLAN , PETER CHARLES ELLIOTT , TERENCE SEWARD BAKER
Abstract: The present invention relates to alpha synuclein binding antibodies and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.
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公开(公告)号：BR112024001989A2
公开(公告)日：2024-04-30
申请号：BR112024001989
申请日：2022-08-19
Applicant: UCB BIOPHARMA SRL
Inventor： ANN LOUISE WHITE , CARL BRENDAN DOYLE , BERTEAU CAROLINE , THOMPSON CLARE , DAVID PAUL HUMPHREYS , GAELLE LE FRIEC , KERRY LOUISE TYSON , DEDI NEESHA , MCELHONE RUTH , COLLEY THOMAS , O?DOWD VICTORIA
IPC: C07K16/28
Abstract: anticorpos anti-hla-g. a presente invenção se refere a anticorpos direcionados contra hla-g e formulações compreendendo os mesmos. a invenção adicionalmente se refere ao uso dos anticorpos de hla-g e formulações em terapia, notavelmente no tratamento de tumores sólidos.
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公开(公告)号：CL2023001509A1
公开(公告)日：2024-01-19
申请号：CL2023001509
申请日：2023-05-25
Applicant: UCB BIOPHARMA SRL
Inventor： RALPH ADAMS , JOSEPH MICHAEL DAVID RASTRICK , JOHN PAUL SILVA , KERRY LOUISE TYSON , PETER CHARLES ELLIOTT , SEPPE FRANS ROMAN LEYSEN , ZAINAB AHDASH , DANIEL JOHN LIGHTWOOD , ROGER THOMAS PALFRAMAN , SEEMA MAYANK , ANDREA JULIE CROSBY , EMILY MARY CAIRISTINE BARRY
IPC: C07K16/24
Abstract: La presente invención se refiere a anticuerpos que se unen a IL13 e IL22. La invención proporciona nuevos anticuerpos multiespecíficos que se unen tanto a IL13 como a IL22 y a composiciones que comprenden un anticuerpo que se une a IL13 y un anticuerpo que se une a IL22. La invención se refiere además a usos terapéuticos de la combinación de anticuerpos anti-IL13 y anti-IL22 y anticuerpos multi-específicos que se unen tanto a IL13 como a IL22.
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公开(公告)号：BR112022015281A2
公开(公告)日：2022-09-20
申请号：BR112022015281
申请日：2021-02-01
Applicant: UCB BIOPHARMA SRL
Inventor： NEESHA DEDI , PETER CHARLES ELLIOTT , SEPPE FRANS ROMAN LEYSEN , SEAN MASON , DAVID JAMES MCMILLAN , GILLIAN CLAIRE NESS , NICCOLO PENGO , MARTIN ANTHONY REDHEAD , ALISON TURNER , KERRY LOUISE TYSON
Abstract: ANTICORPOS CONTRA KLK5. A presente invenção se refere a anticorpos que ligam e inibem KLK5 e métodos de usar os mesmos para tratar doenças causadas pelo desequilíbrio de KLK5. Em particular, a presente invenção se refere a anticorpos inibidores da ligação de KLK5 e seu uso no tratamento da doença de Netherton, dermatite atópica e câncer.
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