公开(公告)号：ES2314090T3

公开(公告)日：2009-03-16

申请号：ES02764832

申请日：2002-08-05

Applicant: UCB PHARMA SA

Inventor： ATES CELAL ,  SURTEES JOHN ,  BURTEAU ANNE-CATHERINE ,  MARMON VIOLETA ,  CAVOY EMILE

IPC: C07D207/26 ,  A61K31/4015 ,  A61P25/08 ,  A61P25/28 ,  C07B61/00 ,  C07D207/27

Abstract: Un compuesto de la fórmula (6) (Ver fórmula) en la que R 1 es metilo o etilo; y R 2 es alquilo-(C2-C4), alquenilo-(C2-C4) o alquinilo-(C2-C4), sustituido opcionalmente con uno o múltiples halógenos; así como los estereoisómeros y mezclas de los mismos.

公开(公告)号：AU2006291524A1

公开(公告)日：2007-03-22

申请号：AU2006291524

申请日：2006-09-12

Applicant: UCB PHARMA SA

Inventor： QUESNEL YANNICK ,  ATES CELAL ,  LURQUIN FRANCOISE ,  SCHULE ARNAUD

IPC: C07D207/26

Abstract: The present invention relates to optically enriched or substantially optically pure 4-substituted-pyrrolidin-2-ones of formula (III), and their uses for the synthesis of 2-oxo-pyrrolidin-1-yl derivatives.

公开(公告)号：CA2620243C

公开(公告)日：2015-01-20

申请号：CA2620243

申请日：2006-09-12

Applicant: UCB PHARMA SA

Inventor： ATES CELAL ,  LURQUIN FRANCOISE ,  QUESNEL YANNICK ,  SCHULE ARNAUD

IPC: C07D207/26

Abstract: The present invention relates to optically enriched or substantially optically pure 4-substituted-pyrrolidin-2-ones of formula (III), and their uses for the synthesis of 2-oxo-pyrrolidin-l-yl derivatives.

公开(公告)号：DE60229267D1

公开(公告)日：2008-11-20

申请号：DE60229267

申请日：2002-08-05

Applicant: UCB PHARMA SA

Inventor： ATES CELAL ,  SURTEES JOHN ,  BURTEAU ANNE-CATHERINE ,  MARMON VIOLETA ,  CAVOY EMILE

IPC: C07D207/26 ,  A61K31/4015 ,  A61P25/08 ,  A61P25/28 ,  C07B61/00 ,  C07D207/27

公开(公告)号：EA016518B1

公开(公告)日：2012-05-30

申请号：EA200800701

申请日：2006-09-12

Applicant: UCB PHARMA SA

Inventor： ATES CELAL ,  LURQUIN FRANCOIS ,  QUESNEL YANNICK ,  SCHULE ARNAUD

IPC: C07D207/26

Abstract: Визобретениипредставленыоптическиобогащенныеилив основномоптическичистые 4-замещенныепирролидин-2-оныформулы (III)иихприменениедлясинтезапроизводных 2-оксопирролидин-1-ила.

公开(公告)号：HK1120498A1

公开(公告)日：2009-04-03

申请号：HK08112155

申请日：2008-11-06

Applicant: UCB PHARMA SA

Inventor： ATES CELAL ,  LURQUIN FRANCOISE ,  QUESNEL YANNICK ,  SCHULE ARNAUD

IPC: C07D20060101

Abstract: The present invention relates to optically enriched or substantially optically pure 4-substituted-pyrrolidin-2-ones of formula (III), and their uses for the synthesis of 2-oxo-pyrrolidin-1-yl derivatives.

公开(公告)号：AT410412T

公开(公告)日：2008-10-15

申请号：AT02764832

申请日：2002-08-05

Applicant: UCB PHARMA SA

Inventor： ATES CELAL ,  SURTEES JOHN ,  BURTEAU ANNE-CATHERINE ,  MARMON VIOLETA ,  CAVOY EMILE

IPC: C07D207/26 ,  A61K31/4015 ,  A61P25/08 ,  A61P25/28 ,  C07B61/00 ,  C07D207/27

公开(公告)号：CA2620243A1

公开(公告)日：2007-03-22

申请号：CA2620243

申请日：2006-09-12

Applicant: UCB PHARMA SA

Inventor： QUESNEL YANNICK ,  LURQUIN FRANCOISE ,  SCHULE ARNAUD ,  ATES CELAL

IPC: C07D207/26

Abstract: The present invention relates to optically enriched or substantially optical ly pure 4-substituted-pyrrolidin-2-ones of formula (III), and their uses for th e synthesis of 2-oxo-pyrrolidin-l-yl derivatives.

公开(公告)号：BRPI0615830A2

公开(公告)日：2012-12-18

申请号：BRPI0615830

申请日：2006-09-12

Applicant: UCB PHARMA SA

Inventor： ATES CELAL ,  QUESNEL YANNICK ,  SCHULE ARNAUD ,  LURQUIN FRANCOISE

IPC: C07D207/26

Abstract: The present invention relates to optically enriched or substantially optically pure 4-substituted-pyrrolidin-2-ones of formula (III), and their uses for the synthesis of 2-oxo-pyrrolidin-1-yl derivatives.

公开(公告)号：NZ566240A

公开(公告)日：2011-05-27

申请号：NZ56624006

申请日：2006-09-12

Applicant: UCB PHARMA SA

Inventor： ATES CELAL ,  LURQUIN FRANCOISE ,  QUESNEL YANNICK ,  SCHULE ARNAUD

IPC: C07D207/26

Abstract: Disclosed is a substantially optically pure 4-substituted-pyrrolidin-2-one of formula (III), wherein R1 is ethyl, n-propyl, a C1-3 alkyl substituted by at least one halogen or a alkenyl substituted by at least two halogen atoms; and wherein substantially optically pure means that at least 95% of the compound of formula (III) has the stereogenic center indicated by (1*) in a given configuration (R) or (S). Also disclosed is a process to prepare said pyrrolidin-2-one.