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公开(公告)号：WO2010035012A9
公开(公告)日：2011-03-17
申请号：PCT/GB2009002310
申请日：2009-09-25
Applicant: UCB PHARMA SA , ADAMS RALPH , HANCOCK LAURA , HEYWOOD SAM PHILIP
Inventor： ADAMS RALPH , HANCOCK LAURA , HEYWOOD SAM PHILIP
CPC classification number: C07K16/468 , C07K16/18 , C07K16/245 , C07K16/28 , C07K16/2878 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/62 , C07K2317/624 , C07K2317/92
Abstract: A multivalent antibody fusion protein which comprises an immunoglobulin moiety, for example a Fab or Fab' fragment, with a first specificity for an antigen of interest, and further comprises two single domain antibodies (dAb) with specificity for a second antigen of interest, wherein the two single domain antibodies are linked by a disulfide bond. There is also provided particular dual specificity antibody fusion proteins comprising a Fab or Fab' fragment and one or more single domain antibodies which may be stabilised by a disulfide bond therebetween.
Abstract translation: 一种多价抗体融合蛋白，其包含对目的抗原具有第一特异性的免疫球蛋白部分，例如Fab或Fab'片段，并且还包含对目的第二抗原具有特异性的两个单结构域抗体（dAb），其中 两个单结构域抗体通过二硫键连接。 还提供了特异的双重特异性抗体融合蛋白，其包含Fab或Fab'片段和一个或多个单结构域抗体，其可以通过它们之间的二硫键来稳定。
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公开(公告)号：BR112012006492A2
公开(公告)日：2016-11-22
申请号：BR112012006492
申请日：2010-09-24
Applicant: UCB PHARMA SA
Inventor： HANCOCK LAURA , ADAMS RALPH , HEYWOOD SAM PHILIP
Abstract: proteína de fusão de anticorpo multivalente, e, ligação de albumina. uma proteína de fusão de anticorpo multivalente que compreende uma porçaõ de imunoglobina, por exemplo um fragmento de fab ou fab', com uma primeira especificidade para um antígeno de interesse, e compreende ainda dois anticorpos de domínio único (dab) com especificoidade para um segundo antígeno de interesse que são par vh/vl, em que os dois anticorpos de domínio único são ligados por uma ligação de dissulfeto. também são fornecidas proteínas de fusão de anticorpo de especificidade dual particulares e outros fragmentos de anticorpo que são estabilizados por uma ligação de dissulfeto.
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Patent Agency Ranking
公开(公告)号：CA2773286A1
公开(公告)日：2011-03-31
申请号：CA2773286
申请日：2010-09-24
Applicant: UCB PHARMA SA
Inventor： ADAMS RALPH , HANCOCK LAURA , HEYWOOD SAM PHILIP
Abstract: A multivalent antibody fusion protein which comprises an immunoglobulin moiety, for example a Fab or Fab' fragment, with a first specificity for an antigen of interest, and further comprises two single domain antibodies (dAb) with specificity for a second antigen of interest which are a VH/VL pair, wherein the two single domain antibodies are linked by a disulfide bond. Also provided are particular dual specificity antibody fusion proteins and other antibody fragments which are stabilised by a disulfide bond.
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公开(公告)号：CA2773286C
公开(公告)日：2020-10-20
申请号：CA2773286
申请日：2010-09-24
Applicant: UCB PHARMA SA
Inventor： ADAMS RALPH , HANCOCK LAURA , HEYWOOD SAM PHILIP
Abstract: A multivalent antibody fusion protein which comprises an immunoglobulin moiety, for example a Fab or Fab' fragment, with a first specificity for an antigen of interest, and further comprises two single domain antibodies (dAb) with specificity for a second antigen of interest which are a VH/VL pair, wherein the two single domain antibodies are linked by a disulfide bond. Also provided are particular dual specificity antibody fusion proteins and other antibody fragments which are stabilised by a disulfide bond.
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公开(公告)号：CA2737241C
公开(公告)日：2017-08-29
申请号：CA2737241
申请日：2009-09-25
Applicant: UCB PHARMA SA
Inventor： ADAMS RALPH , HANCOCK LAURA , HEYWOOD SAM PHILIP
Abstract: A multivalent antibody fusion protein which comprises an immunoglobulin moiety, for example a Fab or Fab' fragment, with a first specificity for an antigen of interest, and further comprises two single domain antibodies (dAb) with specificity for a second antigen of interest, wherein the two single domain antibodies are linked by a disulfide bond. There is also provided particular dual specificity antibody fusion proteins comprising a Fab or Fab' fragment and one or more single domain antibodies which may be stabilised by a disulfide bond therebetween.
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公开(公告)号：BRPI0918947A2
公开(公告)日：2015-12-01
申请号：BRPI0918947
申请日：2009-09-25
Applicant: UCB PHARMA SA
Inventor： HANCOCK LAURA , ADAMS RALPH , HEYWOOD SAM PHILIP
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公开(公告)号：CA2737241A1
公开(公告)日：2010-04-01
申请号：CA2737241
申请日：2009-09-25
Applicant: UCB PHARMA SA
Inventor： ADAMS RALPH , HANCOCK LAURA , HEYWOOD SAM PHILIP
Abstract: A multivalent antibody fusion protein which comprises an immunoglobulin moiety, for example a Fab or Fab' fragment, with a first specificity for an antigen of interest, and further comprises two single domain antibodies (dAb) with specificity for a second antigen of interest, wherein the two single domain antibodies are linked by a disulfide bond. There is also provided particular dual specificity antibody fusion proteins comprising a Fab or Fab' fragment and one or more single domain antibodies which may be stabilised by a disulfide bond therebetween.
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