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公开(公告)号：WO2007003898A8
公开(公告)日：2008-10-09
申请号：PCT/GB2006002416
申请日：2006-06-29
Applicant: UCB PHARMA SA , HEYWOOD SAM PHILIP
Inventor： HEYWOOD SAM PHILIP
IPC: A61K39/395 , A61K47/48
CPC classification number: A61K47/60 , C07K2317/55
Abstract: The present invention provides a process for attaching one or more effector molecules to one or more cysteines in a protein comprising: a) activating one or more cysteines in the protein by diafiltering the protein against a monothiol reducing agent or a multi-thiol reducing agent which is incapable of forming intramolecular disulphide bonds and b) reacting the treated protein with an effector molecule.
Abstract translation: 本发明提供了将一种或多种效应分子连接到蛋白质中的一个或多个半胱氨酸的方法，其包括：a）通过将蛋白质反渗透单硫醇还原剂或多硫醇还原剂来活化蛋白质中的一个或多个半胱氨酸 不能形成分子内二硫键，和b）使经处理的蛋白质与效应分子反应。
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公开(公告)号：WO2011061492A2
公开(公告)日：2011-05-26
申请号：PCT/GB2010002120
申请日：2010-11-17
Applicant: UCB PHARMA SA , HUMPHREYS DAVID PAUL , HEYWOOD SAM PHILIP , LAWSON ALASTAIR DAVID GRIFFITHS
IPC: C07K16/00
CPC classification number: C07K16/00 , A61K47/60 , C07K2317/522 , C07K2317/55 , C07K2317/60 , C07K2317/624
Abstract: A multivalent antibody fusion protein comprising: a heavy chain comprising, in sequence from the N-terminal, a variable domain nominally VH1, a CH1 region and a further variable domain nominally VH2, a light chain comprising, in sequence from the N-terminal, a variable domain nominally VL1, a CL domain and a variable domain nominally VL2, wherein said heavy and light chains are aligned to provide a first binding site formed by a first variable domain pair of VH1 and VL1 and a second binding site formed by a second variable domain pair of VH2 and VL2, wherein there is a disulfide bond between a variable domain pair forming a binding site, and said fusion protein is conjugated to a PEG polymer.
Abstract translation: 一种多价抗体融合蛋白，其包含：重链，其从N末端依次包含名义上为VH1的可变结构域，CH1区域和名义上为VH2的另外的可变区，轻链，其从N末端依次包含， 可变结构域名义上为VL1，CL结构域和名义上为VL2的可变结构域，其中所述重链和轻链对齐以提供由第一可变结构域对VH1和VL1形成的第一结合位点和由第二结合位点形成的第二结合位点 VH2和VL2的可变结构域对，其中在形成结合位点的可变结构域对之间存在二硫键，并且所述融合蛋白与PEG聚合物缀合。
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公开(公告)号：WO2011061246A2
公开(公告)日：2011-05-26
申请号：PCT/EP2010067731
申请日：2010-11-18
Applicant: UCB PHARMA SA , HEYWOOD SAM PHILIP , HUMPHREYS DAVID PAUL , LAWSON ALASTAIR DAVID GRIFFITHS
IPC: C07K16/00
CPC classification number: C07K16/00 , C07K2317/35 , C07K2319/30 , C07K2319/31
Abstract: A multivalent antibody fusion protein comprising: a heavy chain comprising, in sequence from the N-terminal, a variable domain nominally VH1, a CH1 region and a further variable domain nominally VH2, a light chain comprising, in sequence from the N-terminal, a variable domain nominally VL1, a CL domain and a variable domain nominally VL2, wherein said heavy and light chains are aligned to provide a first binding site formed by a first variable domain pair of VH1 and VL1 and a second binding site formed by a second variable domain pair of VH2 and VL2, and said fusion protein is conjugated to a PEG polymer.
Abstract translation: 一种多价抗体融合蛋白，其包含：重链，其从N-末端开始依次包含可变结构域名义上的VH1，CH1区和另外的可变结构域名义上的VH2，轻链依次包含N-末端， 可变结构域名义上为VL1，CL结构域和名义上可变域为VL2，其中所述重链和轻链对齐以提供由VH1和VL1的第一可变结构域对形成的第一结合位点和由第二可变结构域形成的第二结合位点 VH2和VL2的可变结构域对，并且所述融合蛋白与PEG聚合物缀合。
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公开(公告)号：WO2010035012A9
公开(公告)日：2011-03-17
申请号：PCT/GB2009002310
申请日：2009-09-25
Applicant: UCB PHARMA SA , ADAMS RALPH , HANCOCK LAURA , HEYWOOD SAM PHILIP
Inventor： ADAMS RALPH , HANCOCK LAURA , HEYWOOD SAM PHILIP
CPC classification number: C07K16/468 , C07K16/18 , C07K16/245 , C07K16/28 , C07K16/2878 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/62 , C07K2317/624 , C07K2317/92
Abstract: A multivalent antibody fusion protein which comprises an immunoglobulin moiety, for example a Fab or Fab' fragment, with a first specificity for an antigen of interest, and further comprises two single domain antibodies (dAb) with specificity for a second antigen of interest, wherein the two single domain antibodies are linked by a disulfide bond. There is also provided particular dual specificity antibody fusion proteins comprising a Fab or Fab' fragment and one or more single domain antibodies which may be stabilised by a disulfide bond therebetween.
Abstract translation: 一种多价抗体融合蛋白，其包含对目的抗原具有第一特异性的免疫球蛋白部分，例如Fab或Fab'片段，并且还包含对目的第二抗原具有特异性的两个单结构域抗体（dAb），其中 两个单结构域抗体通过二硫键连接。 还提供了特异的双重特异性抗体融合蛋白，其包含Fab或Fab'片段和一个或多个单结构域抗体，其可以通过它们之间的二硫键来稳定。
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公开(公告)号：CA2773286C
公开(公告)日：2020-10-20
申请号：CA2773286
申请日：2010-09-24
Applicant: UCB PHARMA SA
Inventor： ADAMS RALPH , HANCOCK LAURA , HEYWOOD SAM PHILIP
Abstract: A multivalent antibody fusion protein which comprises an immunoglobulin moiety, for example a Fab or Fab' fragment, with a first specificity for an antigen of interest, and further comprises two single domain antibodies (dAb) with specificity for a second antigen of interest which are a VH/VL pair, wherein the two single domain antibodies are linked by a disulfide bond. Also provided are particular dual specificity antibody fusion proteins and other antibody fragments which are stabilised by a disulfide bond.
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Patent Agency Ranking
公开(公告)号：CA2737241C
公开(公告)日：2017-08-29
申请号：CA2737241
申请日：2009-09-25
Applicant: UCB PHARMA SA
Inventor： ADAMS RALPH , HANCOCK LAURA , HEYWOOD SAM PHILIP
Abstract: A multivalent antibody fusion protein which comprises an immunoglobulin moiety, for example a Fab or Fab' fragment, with a first specificity for an antigen of interest, and further comprises two single domain antibodies (dAb) with specificity for a second antigen of interest, wherein the two single domain antibodies are linked by a disulfide bond. There is also provided particular dual specificity antibody fusion proteins comprising a Fab or Fab' fragment and one or more single domain antibodies which may be stabilised by a disulfide bond therebetween.
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公开(公告)号：BRPI0918947A2
公开(公告)日：2015-12-01
申请号：BRPI0918947
申请日：2009-09-25
Applicant: UCB PHARMA SA
Inventor： HANCOCK LAURA , ADAMS RALPH , HEYWOOD SAM PHILIP
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公开(公告)号：AT541590T
公开(公告)日：2012-02-15
申请号：AT04743216
申请日：2004-07-01
Applicant: UCB PHARMA SA
Inventor： HUMPHREYS DAVID PAUL , HEYWOOD SAM PHILIP , CARRINGTON BRUCE
Abstract: The present invention provides an antibody Fab or Fab' fragment to which at least one effector molecule is attached characterized in that the heavy chain in the fragment is not covalently bonded to the light chain and both the interchain cysteine of C L and the interchain cysteine of C H 1 have been replaced with another amino acid.
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公开(公告)号：CA2780242A1
公开(公告)日：2011-05-26
申请号：CA2780242
申请日：2010-11-17
Applicant: UCB PHARMA SA
Abstract: A multivalent antibody fusion protein comprising: a heavy chain comprising, in sequence from the N-terminal, a variable domain nominally VH1, a CH1 region and a further variable domain nominally VH2, a light chain comprising, in sequence from the N-terminal, a variable domain nominally VL1, a CL domain and a variable domain nominally VL2, wherein said heavy and light chains are aligned to provide a first binding site formed by a first variable domain pair of VH1 and VL1 and a second binding site formed by a second variable domain pair of VH2 and VL2, wherein there is a disulfide bond between a variable domain pair forming a binding site, and said fusion protein is conjugated to a PEG polymer.
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公开(公告)号：CA2737241A1
公开(公告)日：2010-04-01
申请号：CA2737241
申请日：2009-09-25
Applicant: UCB PHARMA SA
Inventor： ADAMS RALPH , HANCOCK LAURA , HEYWOOD SAM PHILIP
Abstract: A multivalent antibody fusion protein which comprises an immunoglobulin moiety, for example a Fab or Fab' fragment, with a first specificity for an antigen of interest, and further comprises two single domain antibodies (dAb) with specificity for a second antigen of interest, wherein the two single domain antibodies are linked by a disulfide bond. There is also provided particular dual specificity antibody fusion proteins comprising a Fab or Fab' fragment and one or more single domain antibodies which may be stabilised by a disulfide bond therebetween.
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