公开(公告)号：WO2012022982A3

公开(公告)日：2012-06-21

申请号：PCT/GB2011051563

申请日：2011-08-19

Applicant: UCB PHARMA SA ,  HUMPHREYS DAVID PAUL ,  PETERS SHIRLEY JANE ,  ADAMS RALPH ,  HEADS JAMES

Inventor： HUMPHREYS DAVID PAUL ,  ADAMS RALPH ,  HEADS JAMES

IPC: C07K16/00 ,  A61K39/395

CPC classification number: C07K16/24 ,  A61K39/39591 ,  C07K16/00 ,  C07K2317/40 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/53 ,  C07K2317/94

Abstract: The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.

Abstract translation: 本发明提供了包含至少一个包含CH1结构域和铰链区的重链的IgG4类抗体，其中在每条重链中：a。 在CH1结构域中根据Kabat编号系统编号的第127位的链间半胱氨酸被另一个氨基酸取代; 和b。 位于上铰链区的一个或多个氨基酸被半胱氨酸取代。

公开(公告)号：MX2013001948A

公开(公告)日：2013-06-28

申请号：MX2013001948

申请日：2011-08-19

Applicant: UCB PHARMA SA

Inventor： PETERS SHIRLEY JANE ,  HUMPHREYS DAVID PAUL ,  ADAMS RALPH ,  HEADS JAMES

IPC: C07K16/00 ,  A61K39/395

Abstract: La presente invención proporciona un anticuerpo de la clase IgG4 que comprende por lo menos una cadena pesada la cual comprende un dominio CH1 y una región de bisagra, en donde en cada cadena pesada: a. la cisteína intercadena en la posición 127, numerada de acuerdo con el sistema de numeración de Kabat, en el dominio CH1 está sustituida con otro aminoácido; y b. uno o más de los aminoácidos colocados en la región de bisagra superior está sustituido con cisteína.

公开(公告)号：AU2011290581B2

公开(公告)日：2015-04-16

申请号：AU2011290581

申请日：2011-08-19

Applicant: UCB PHARMA SA

Inventor： HUMPHREYS DAVID PAUL ,  PETERS SHIRLEY JANE ,  ADAMS RALPH ,  HEADS JAMES

IPC: C07K16/00 ,  A61K39/395

Abstract: The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a C

公开(公告)号：CA2807227C

公开(公告)日：2021-03-23

申请号：CA2807227

申请日：2011-08-19

Applicant: UCB PHARMA SA

Inventor： HUMPHREYS DAVID PAUL ,  ADAMS RALPH ,  HEADS JAMES ,  PETERS SHIRLEY JANE

IPC: C07K16/00 ,  A61K39/395 ,  C12N15/13

Abstract: The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.

公开(公告)号：AU2011290581A1

公开(公告)日：2013-04-04

申请号：AU2011290581

申请日：2011-08-19

Applicant: UCB PHARMA SA

Inventor： HUMPHREYS DAVID PAUL ,  PETERS SHIRLEY JANE ,  ADAMS RALPH ,  HEADS JAMES

IPC: C07K16/00 ,  A61K39/395

Abstract: The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a C

公开(公告)号：SG187677A1

公开(公告)日：2013-03-28

申请号：SG2013007950

申请日：2011-08-19

Applicant: UCB PHARMA SA

Inventor： HUMPHREYS DAVID PAUL ,  PETERS SHIRLEY JANE ,  ADAMS RALPH ,  HEADS JAMES

Abstract: The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.

公开(公告)号：CA3080547A1

公开(公告)日：2012-02-23

申请号：CA3080547

申请日：2011-08-19

Applicant: UCB PHARMA SA

Inventor： ADAMS RALPH ,  HEADS JAMES ,  HUMPHREYS DAVID PAUL ,  PETERS SHIRLEY JANE

IPC: C07K16/00 ,  A61K39/395 ,  C12N15/13

Abstract: The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.

公开(公告)号：BR112013003262A2

公开(公告)日：2016-06-14

申请号：BR112013003262

申请日：2011-08-19

Applicant: UCB PHARMA SA

Inventor： HUMPHREYS DAVID PAUL ,  HEADS JAMES ,  ADAMS RALPH ,  PETERS SHIRLEU JANE

IPC: A61K39/395 ,  C07K16/00

Abstract: anticorpos melhorados da classe igg4. a presente invenção fornece um anticorpo da classe igg4 que compreendendo pelo menos uma cadeia pesada que compreende um domínio de c 1 e uma região da dobradiça em que em cada cadeia pesada: a. a cisteína inter-cadeias na posição 127, numerada de acordo com o sistema de numeração kabat, no domínio de c 1 é substituída com outro aminoácido; e b. um ou mais dos aminoácidos posicionados na região da dobradiça superior são substituídos com cisteína.

公开(公告)号：SG10201506492PA

公开(公告)日：2015-10-29

申请号：SG10201506492P

申请日：2011-08-19

Applicant: UCB PHARMA SA

Inventor： HUMPHREYS DAVID PAUL ,  PETERS SHIRLEY JANE ,  ADAMS RALPH ,  HEADS JAMES

Abstract: The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.

公开(公告)号：CA2807227A1

公开(公告)日：2012-02-23

申请号：CA2807227

申请日：2011-08-19

Applicant: UCB PHARMA SA

Inventor： HUMPHREYS DAVID PAUL ,  ADAMS RALPH ,  HEADS JAMES ,  PETERS SHIRLEY JANE

IPC: C07K16/00 ,  A61K39/395

Abstract: The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.