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公开(公告)号：WO2008020206A2
公开(公告)日：2008-02-21
申请号：PCT/GB2007003114
申请日：2007-08-15
Applicant: UCB PHARMA SA , LAING VICTORIA ELIZABETH , BROOKINGS DANIEL CHRISTOPHER , CARBERY RACHEL JANE , GASCON SIMORTE JOSE MIGUEL , HUTCHINGS MARTIN CLIVE , LANGHAM BARRY JOHN , LOWE MARTIN ALEXANDER
Inventor： LAING VICTORIA ELIZABETH , BROOKINGS DANIEL CHRISTOPHER , CARBERY RACHEL JANE , GASCON SIMORTE JOSE MIGUEL , HUTCHINGS MARTIN CLIVE , LANGHAM BARRY JOHN , LOWE MARTIN ALEXANDER
CPC classification number: C07D495/04
Abstract: A series of 4,5,6,7-tetrahydrothieno[2,3-c]azepin-8-one derivatives, and analogues thereof, which are substituted in the 2-position by a substituted anilino moiety, being selective inhibitors of human MEK (MAPKK) enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, proliferative (including oncological) and nociceptive conditions.
Abstract translation: 一系列4,5,6,7-四氢噻吩并[2,3-c]吖庚因-8-酮衍生物及其类似物，其在2-位被取代的苯胺基部分取代，是人MEK的选择性抑制剂 （MAPKK）酶相应地在医学中有益，例如在治疗炎症，自身免疫，心血管，增殖（包括肿瘤）和伤害性疾病）中。
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2.发明申请NOVEL AMINOTHIENOPYRIDINONE DERIVATIVES PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS THEREOF 审中-公开新型氨基苯并吡啶酮衍生物制备其药物组合物及其药物组合物的方法
公开(公告)号：WO2008064829A3
公开(公告)日：2008-10-23
申请号：PCT/EP2007010189
申请日：2007-11-23
Applicant: UCB PHARMA SA , DAVIS JEREMY MARTIN , BROOKINGS DANIEL CHRISTOPHER , LANGHAM BARRY JOHN , HUTCHINGS MARTIN CLIVE
Inventor： DAVIS JEREMY MARTIN , BROOKINGS DANIEL CHRISTOPHER , LANGHAM BARRY JOHN , HUTCHINGS MARTIN CLIVE
IPC: C07D495/04 , A61K31/4365 , A61P29/00
CPC classification number: C07D495/04
Abstract: The present invention concerns novel 3-aminothienopyridinone derivatives of the formula I, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
Abstract translation: 本发明涉及式I的新型3-氨基噻吩并吡啶酮衍生物，其制备方法，含有它们的药物组合物及其作为药物的用途。
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公开(公告)号：CA2640594C
公开(公告)日：2014-12-23
申请号：CA2640594
申请日：2007-01-30
Applicant: UCB PHARMA SA
Inventor： HUTCHINGS MARTIN CLIVE , ARCHIBALD SARAH CATHERINE , BROOKINGS DANIEL CHRISTOPHER , DAVIS JEREMY MARTIN , JOHNSON JAMES ANDREW , LANGHAM BARRY JOHN , NEUSS JUDI CHARLOTTE
IPC: C07D495/04 , A61K31/4365
Abstract: A series of thieno¢2,3-b!pyridine derivatives which are substituted in the 2-position by a substituted anilino moiety, being selective inhibitors of human MEK (MAPKK) enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, proliferative (including oncological) and nociceptive conditions.
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公开(公告)号：PL1981892T3
公开(公告)日：2014-08-29
申请号：PL07705076
申请日：2007-01-30
Applicant: UCB PHARMA SA
Inventor： HUTCHINGS MARTIN CLIVE , ARCHIBALD SARAH CATHERINE , BROOKINGS DANIEL CHRISTOPHER , DAVIS JEREMY MARTIN , JOHNSON JAMES ANDREW , LANGHAM BARRY JOHN , NEUSS JUDI CHARLOTTE
IPC: C07D495/04 , A61K31/4365
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公开(公告)号：PT1981892E
公开(公告)日：2014-06-23
申请号：PT07705076
申请日：2007-01-30
Applicant: UCB PHARMA SA
Inventor： HUTCHINGS MARTIN CLIVE , ARCHIBALD SARAH CATHERINE , BROOKINGS DANIEL CHRISTOPHER , DAVIS JEREMY MARTIN , JOHNSON JAMES ANDREW , NEUSS JUDI CHARLOTTE , LANGHAM BARRY JOHN
IPC: C07D495/04 , A61K31/4365
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Patent Agency Ranking
公开(公告)号：DK1981892T3
公开(公告)日：2014-06-23
申请号：DK07705076
申请日：2007-01-30
Applicant: UCB PHARMA SA
Inventor： HUTCHINGS MARTIN CLIVE , ARCHIBALD SARAH CATHERINE , BROOKINGS DANIEL CHRISTOPHER , DAVIS JEREMY MARTIN , JOHNSON JAMES ANDREW , LANGHAM BARRY JOHN , NEUSS JUDI CHARLOTTE
IPC: C07D495/04 , A61K31/4365
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公开(公告)号：NZ569638A
公开(公告)日：2010-08-27
申请号：NZ56963807
申请日：2007-01-30
Applicant: UCB PHARMA SA
Inventor： HUTCHINGS MARTIN CLIVE , ARCHIBALD SARAH CATHERINE , DAVIS JEREMY MARTIN , NEUSS JUDI CHARLOTTE , BROOKINGS DANIEL CHRISTOPHER , JOHNSON JAMES ANDREW , LANGHAM BARRY JOHN
IPC: C07D495/04 , A61K31/4365
Abstract: Disclosed is a compound of formula (I) wherein R3 is NRbRc which represents a cyclic group and the remaining substituents are as defined in the specification, and its use for treating MEK associated disorders, inflammation, automimmune, cardiovascular, proliferative and nociceptive conditions.
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公开(公告)号：HK1125924A1
公开(公告)日：2009-08-21
申请号：HK09103590
申请日：2009-04-20
Applicant: UCB PHARMA SA
Inventor： HUTCHINGS MARTIN CLIVE , ARCHIBALD SARAH CATHERINE , BROOKINGS DANIEL CHRISTOPHER , DAVIS JEREMY MARTIN , JOHNSON JAMES ANDREW , LANGHAM BARRY JOHN , NEUSS JUDI CHARLOTTE
IPC: C07D20060101 , A61K20060101
Abstract: Novel processes for the preparation of thieno[2,3-b]pyridine derivatives which are substituted in the 2-position by a substituted anilino moiety and intermediates thereto are provided. The compounds prepared by the present processes may be useful, for example, as selective inhibitors of human MEK (MAPKK) enzymes, and are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, proliferative (including oncological) and nociceptive conditions. The present processes may offer improved yields, chemical or stereochemical purity, ease of preparation and/or isolation of intermediates and final product, and more industrially useful reaction conditions and workability.
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公开(公告)号：NO341064B1
公开(公告)日：2017-08-14
申请号：NO20083739
申请日：2008-08-29
Applicant: UCB PHARMA SA
Inventor： HUTCHINGS MARTIN CLIVE , ARCHIBALD SARAH CATHERINE , BROOKINGS DANIEL CHRISTOPHER , DAVIS JEREMY MARTIN , JOHNSON JAMES ANDREW , LANGHAM BARRY JOHN , NEUSS JUDI CHARLOTTE
IPC: C07D495/04 , A61K31/365
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公开(公告)号：SI1981892T1
公开(公告)日：2014-07-31
申请号：SI200731467
申请日：2007-01-30
Applicant: UCB PHARMA SA
Inventor： HUTCHINGS MARTIN CLIVE , ARCHIBALD SARAH CATHERINE , BROOKINGS DANIEL CHRISTOPHER , DAVIS JEREMY MARTIN , JOHNSON JAMES ANDREW , LANGHAM BARRY JOHN , NEUSS JUDI CHARLOTTE
IPC: C07D495/00 , A61K31/00
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