公开(公告)号：WO2008020206A2

公开(公告)日：2008-02-21

申请号：PCT/GB2007003114

申请日：2007-08-15

Applicant: UCB PHARMA SA ,  LAING VICTORIA ELIZABETH ,  BROOKINGS DANIEL CHRISTOPHER ,  CARBERY RACHEL JANE ,  GASCON SIMORTE JOSE MIGUEL ,  HUTCHINGS MARTIN CLIVE ,  LANGHAM BARRY JOHN ,  LOWE MARTIN ALEXANDER

Inventor： LAING VICTORIA ELIZABETH ,  BROOKINGS DANIEL CHRISTOPHER ,  CARBERY RACHEL JANE ,  GASCON SIMORTE JOSE MIGUEL ,  HUTCHINGS MARTIN CLIVE ,  LANGHAM BARRY JOHN ,  LOWE MARTIN ALEXANDER

IPC: C07D495/04 ,  A61K31/55 ,  A61P9/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00

CPC classification number: C07D495/04

Abstract: A series of 4,5,6,7-tetrahydrothieno[2,3-c]azepin-8-one derivatives, and analogues thereof, which are substituted in the 2-position by a substituted anilino moiety, being selective inhibitors of human MEK (MAPKK) enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, proliferative (including oncological) and nociceptive conditions.

Abstract translation: 一系列4,5,6,7-四氢噻吩并[2,3-c]吖庚因-8-酮衍生物及其类似物，其在2-位被取代的苯胺基部分取代，是人MEK的选择性抑制剂 （MAPKK）酶相应地在医学中有益，例如在治疗炎症，自身免疫，心血管，增殖（包括肿瘤）和伤害性疾病）中。

公开(公告)号：WO2013024291A2

公开(公告)日：2013-02-21

申请号：PCT/GB2012051992

申请日：2012-08-15

Applicant: UCB PHARMA SA ,  UNIV LEUVEN KATH ,  BROOKINGS DANIEL CHRISTOPHER ,  FORD DANIEL JAMES ,  GHAWALKAR ANANT RAMRAO ,  HERMAN JEAN ,  HUANG QIUYA ,  KULISA CLAIRE LOUISE ,  LOUAT THIERRY ,  NEUSS JUDI CHARLOTTE ,  REUBERSON JAMES THOMAS ,  VANDERHOYDONCK BART

Inventor： BROOKINGS DANIEL CHRISTOPHER ,  FORD DANIEL JAMES ,  GHAWALKAR ANANT RAMRAO ,  HERMAN JEAN ,  HUANG QIUYA ,  KULISA CLAIRE LOUISE ,  LOUAT THIERRY ,  NEUSS JUDI CHARLOTTE ,  REUBERSON JAMES THOMAS ,  VANDERHOYDONCK BART

IPC: C07D495/04 ,  A61K31/519 ,  A61P29/00 ,  C07D513/04 ,  C07D519/00

CPC classification number: C07D495/04 ,  A61K31/519 ,  C07D513/04 ,  C07D519/00

Abstract: A series of monocyclic or bicyclic diamine-substituted thieno[2,3-d]pyrimidine and isothiazolo[5,4-d]pyrimidine derivatives are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.

Abstract translation: 一系列单环或双环二胺取代的噻吩并[2,3-d]嘧啶和异噻唑并[5,4-d]嘧啶衍生物有益于治疗和/或预防各种人类疾病，包括炎症，自身免疫和肿瘤疾病 ; 病毒性疾病; 和器官和细胞移植排斥反应。

公开(公告)号：WO2008064829A3

公开(公告)日：2008-10-23

申请号：PCT/EP2007010189

申请日：2007-11-23

Applicant: UCB PHARMA SA ,  DAVIS JEREMY MARTIN ,  BROOKINGS DANIEL CHRISTOPHER ,  LANGHAM BARRY JOHN ,  HUTCHINGS MARTIN CLIVE

Inventor： DAVIS JEREMY MARTIN ,  BROOKINGS DANIEL CHRISTOPHER ,  LANGHAM BARRY JOHN ,  HUTCHINGS MARTIN CLIVE

IPC: C07D495/04 ,  A61K31/4365 ,  A61P29/00

CPC classification number: C07D495/04

Abstract: The present invention concerns novel 3-aminothienopyridinone derivatives of the formula I, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

Abstract translation: 本发明涉及式I的新型3-氨基噻吩并吡啶酮衍生物，其制备方法，含有它们的药物组合物及其作为药物的用途。

公开(公告)号：CA2640594C

公开(公告)日：2014-12-23

申请号：CA2640594

申请日：2007-01-30

Applicant: UCB PHARMA SA

Inventor： HUTCHINGS MARTIN CLIVE ,  ARCHIBALD SARAH CATHERINE ,  BROOKINGS DANIEL CHRISTOPHER ,  DAVIS JEREMY MARTIN ,  JOHNSON JAMES ANDREW ,  LANGHAM BARRY JOHN ,  NEUSS JUDI CHARLOTTE

IPC: C07D495/04 ,  A61K31/4365

Abstract: A series of thieno¢2,3-b!pyridine derivatives which are substituted in the 2-position by a substituted anilino moiety, being selective inhibitors of human MEK (MAPKK) enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, proliferative (including oncological) and nociceptive conditions.

公开(公告)号：PL1981892T3

公开(公告)日：2014-08-29

申请号：PL07705076

申请日：2007-01-30

Applicant: UCB PHARMA SA

Inventor： HUTCHINGS MARTIN CLIVE ,  ARCHIBALD SARAH CATHERINE ,  BROOKINGS DANIEL CHRISTOPHER ,  DAVIS JEREMY MARTIN ,  JOHNSON JAMES ANDREW ,  LANGHAM BARRY JOHN ,  NEUSS JUDI CHARLOTTE

IPC: C07D495/04 ,  A61K31/4365

公开(公告)号：PT1981892E

公开(公告)日：2014-06-23

申请号：PT07705076

申请日：2007-01-30

Applicant: UCB PHARMA SA

Inventor： HUTCHINGS MARTIN CLIVE ,  ARCHIBALD SARAH CATHERINE ,  BROOKINGS DANIEL CHRISTOPHER ,  DAVIS JEREMY MARTIN ,  JOHNSON JAMES ANDREW ,  NEUSS JUDI CHARLOTTE ,  LANGHAM BARRY JOHN

IPC: C07D495/04 ,  A61K31/4365

公开(公告)号：DK1981892T3

公开(公告)日：2014-06-23

申请号：DK07705076

申请日：2007-01-30

Applicant: UCB PHARMA SA

Inventor： HUTCHINGS MARTIN CLIVE ,  ARCHIBALD SARAH CATHERINE ,  BROOKINGS DANIEL CHRISTOPHER ,  DAVIS JEREMY MARTIN ,  JOHNSON JAMES ANDREW ,  LANGHAM BARRY JOHN ,  NEUSS JUDI CHARLOTTE

IPC: C07D495/04 ,  A61K31/4365

公开(公告)号：NZ569638A

公开(公告)日：2010-08-27

申请号：NZ56963807

申请日：2007-01-30

Applicant: UCB PHARMA SA

Inventor： HUTCHINGS MARTIN CLIVE ,  ARCHIBALD SARAH CATHERINE ,  DAVIS JEREMY MARTIN ,  NEUSS JUDI CHARLOTTE ,  BROOKINGS DANIEL CHRISTOPHER ,  JOHNSON JAMES ANDREW ,  LANGHAM BARRY JOHN

IPC: C07D495/04 ,  A61K31/4365

Abstract: Disclosed is a compound of formula (I) wherein R3 is NRbRc which represents a cyclic group and the remaining substituents are as defined in the specification, and its use for treating MEK associated disorders, inflammation, automimmune, cardiovascular, proliferative and nociceptive conditions.

公开(公告)号：HK1125924A1

公开(公告)日：2009-08-21

申请号：HK09103590

申请日：2009-04-20

Applicant: UCB PHARMA SA

Inventor： HUTCHINGS MARTIN CLIVE ,  ARCHIBALD SARAH CATHERINE ,  BROOKINGS DANIEL CHRISTOPHER ,  DAVIS JEREMY MARTIN ,  JOHNSON JAMES ANDREW ,  LANGHAM BARRY JOHN ,  NEUSS JUDI CHARLOTTE

IPC: C07D20060101 ,  A61K20060101

Abstract: Novel processes for the preparation of thieno[2,3-b]pyridine derivatives which are substituted in the 2-position by a substituted anilino moiety and intermediates thereto are provided. The compounds prepared by the present processes may be useful, for example, as selective inhibitors of human MEK (MAPKK) enzymes, and are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, proliferative (including oncological) and nociceptive conditions. The present processes may offer improved yields, chemical or stereochemical purity, ease of preparation and/or isolation of intermediates and final product, and more industrially useful reaction conditions and workability.

公开(公告)号：CA2808959C

公开(公告)日：2018-07-17

申请号：CA2808959

申请日：2011-09-02

Applicant: UCB PHARMA SA

Inventor： PARTON ANDREW HARRY ,  ALI MEZHER HUSSEIN ,  BROOKINGS DANIEL CHRISTOPHER ,  BROWN JULIEN ALISTAIR ,  FORD DANIEL JAMES ,  FRANKLIN RICHARD JEREMY ,  LANGHAM BARRY JOHN ,  NEUSS JUDI CHARLOTTE ,  QUINCEY JOANNA RACHEL

IPC: C07D471/04 ,  A61K31/519 ,  A61P9/00 ,  A61P25/28 ,  A61P29/00

Abstract: A series of quinoline and quinoxaline derivatives comprising a fluorinated ethyl side-chain, being selective inhibitors of P13 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.