公开(公告)号：CA2788967C

公开(公告)日：2019-02-26

申请号：CA2788967

申请日：2011-02-02

Applicant: UCB PHARMA SA

Inventor： BILGISCHER JEAN-PASCAL PIERRE ,  BASSETT PHILIP JONATHAN ,  PEARCE-HIGGINS MARK ROBERT ,  KENNY ANDREW JOHN

IPC: C07K16/00

Abstract: The present disclosure relates to a method for the manufacture of recombinant antibody molecules comprising culturing a host cell sample transformed with an expression vector encoding a recombinant antibody molecule; adding an extraction buffer to the sample; and subjecting the sample to a heat treatment step; wherein the pH of the sample is detected after addition of the extraction buffer, and optionally adjusted, to ensure that the pH of the sample is 6 to 9 prior to the heat treatment step.

公开(公告)号：SG10201408639RA

公开(公告)日：2015-02-27

申请号：SG10201408639R

申请日：2011-02-02

Applicant: UCB PHARMA SA

Inventor： BILGISCHER JEAN-PASCAL PIERRE ,  BASSETT PHILIP JONATHAN ,  PEARCE-HIGGINS MARK ROBERT ,  KENNY ANDREW JOHN

Abstract: The present disclosure relates to a method for the manufacture of recombinant antibody molecules comprising culturing a host cell sample transformed with an expression vector encoding a recombinant antibody molecule; adding an extraction buffer to the sample; and subjecting the sample to a heat treatment step; wherein the pH of the sample is detected after addition of the extraction buffer, and optionally adjusted, to ensure that the pH of the sample is 6 to 9 prior to the heat treatment step.

公开(公告)号：AU2011212493B2

公开(公告)日：2016-11-03

申请号：AU2011212493

申请日：2011-02-02

Applicant: UCB PHARMA SA

Inventor： BILGISCHER JEAN-PASCAL PIERRE ,  BASSETT PHILIP JONATHAN ,  PEARCE-HIGGINS MARK ROBERT ,  KENNY ANDREW JOHN

IPC: C07K16/00

Abstract: The present disclosure relates to a method for the manufacture of recombinant antibody molecules comprising culturing a host cell sample transformed with an expression vector encoding a recombinant antibody molecule; adding an extraction buffer to the sample; and subjecting the sample to a heat treatment step; wherein the pH of the sample is detected after addition of the extraction buffer, and optionally adjusted, to ensure that the pH of the sample is 6 to 9 prior to the heat treatment step.

公开(公告)号：SG183151A1

公开(公告)日：2012-09-27

申请号：SG2012057519

申请日：2011-02-02

Applicant: UCB PHARMA SA

Inventor： BILGISCHER JEAN-PASCAL PIERRE ,  BASSETT PHILIP JONATHAN ,  PEARCE-HIGGINS MARK ROBERT ,  KENNY ANDREW JOHN

Abstract: The present disclosure relates to a method for the manufacture of recombinant antibody molecules comprising culturing a host cell sample transformed with an expression vector encoding a recombinant antibody molecule; adding an extraction buffer to the sample; and subjecting the sample to a heat treatment step; wherein the pH of the sample is detected after addition of the extraction buffer, and optionally adjusted, to ensure that the pH of the sample is 6 to 9 prior to the heat treatment step.

公开(公告)号：CA2788967A1

公开(公告)日：2011-08-11

申请号：CA2788967

申请日：2011-02-02

Applicant: UCB PHARMA SA

Inventor： BILGISCHER JEAN-PASCAL PIERRE ,  BASSETT PHILIP JONATHAN ,  PEARCE-HIGGINS MARK ROBERT ,  KENNY ANDREW JOHN

IPC: C07K16/00

Abstract: The present disclosure relates to a method for the manufacture of recombinant antibody molecules comprising culturing a host cell sample transformed with an expression vector encoding a recombinant antibody molecule; adding an extraction buffer to the sample; and subjecting the sample to a heat treatment step; wherein the pH of the sample is detected after addition of the extraction buffer, and optionally adjusted, to ensure that the pH of the sample is 6 to 9 prior to the heat treatment step.

公开(公告)号：AU2011212493A1

公开(公告)日：2012-08-30

申请号：AU2011212493

申请日：2011-02-02

Applicant: UCB PHARMA SA

Inventor： BILGISCHER JEAN-PASCAL PIERRE ,  BASSETT PHILIP JONATHAN ,  PEARCE-HIGGINS MARK ROBERT ,  KENNY ANDREW JOHN

IPC: C07K16/00

Abstract: The present disclosure relates to a method for the manufacture of recombinant antibody molecules comprising culturing a host cell sample transformed with an expression vector encoding a recombinant antibody molecule; adding an extraction buffer to the sample; and subjecting the sample to a heat treatment step; wherein the pH of the sample is detected after addition of the extraction buffer, and optionally adjusted, to ensure that the pH of the sample is 6 to 9 prior to the heat treatment step.