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公开(公告)号：WO2012013682A3
公开(公告)日：2012-05-18
申请号：PCT/EP2011062837
申请日：2011-07-26
Applicant: UCB PHARMA SA , SPITALI MARIANGELA , SYMMONS JONATHAN , WHITCOMBE RICHARD , PEARCE-HIGGINS MARK ROBERT
CPC classification number: C07K16/241 , C07K1/18 , C07K1/36 , C07K2317/14 , C07K2317/55
Abstract: The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.
Abstract translation: 本发明涉及从周质细胞提取物纯化抗体片段的方法，其包括第一阳离子交换层析步骤和第二阴离子交换层析步骤。
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公开(公告)号：AU2011212493B2
公开(公告)日：2016-11-03
申请号：AU2011212493
申请日：2011-02-02
Applicant: UCB PHARMA SA
Inventor： BILGISCHER JEAN-PASCAL PIERRE , BASSETT PHILIP JONATHAN , PEARCE-HIGGINS MARK ROBERT , KENNY ANDREW JOHN
IPC: C07K16/00
Abstract: The present disclosure relates to a method for the manufacture of recombinant antibody molecules comprising culturing a host cell sample transformed with an expression vector encoding a recombinant antibody molecule; adding an extraction buffer to the sample; and subjecting the sample to a heat treatment step; wherein the pH of the sample is detected after addition of the extraction buffer, and optionally adjusted, to ensure that the pH of the sample is 6 to 9 prior to the heat treatment step.
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公开(公告)号：AU2011284896B2
公开(公告)日：2016-06-16
申请号：AU2011284896
申请日：2011-07-26
Applicant: UCB PHARMA SA
Abstract: The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.
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公开(公告)号：CA2788967C
公开(公告)日：2019-02-26
申请号：CA2788967
申请日：2011-02-02
Applicant: UCB PHARMA SA
Inventor： BILGISCHER JEAN-PASCAL PIERRE , BASSETT PHILIP JONATHAN , PEARCE-HIGGINS MARK ROBERT , KENNY ANDREW JOHN
IPC: C07K16/00
Abstract: The present disclosure relates to a method for the manufacture of recombinant antibody molecules comprising culturing a host cell sample transformed with an expression vector encoding a recombinant antibody molecule; adding an extraction buffer to the sample; and subjecting the sample to a heat treatment step; wherein the pH of the sample is detected after addition of the extraction buffer, and optionally adjusted, to ensure that the pH of the sample is 6 to 9 prior to the heat treatment step.
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公开(公告)号：BR112013000623A2
公开(公告)日：2016-05-24
申请号：BR112013000623
申请日：2011-07-26
Applicant: UCB PHARMA SA
Abstract: purificação de proteína. a presente invenção diz respeito a um processo para a purificação de um fragmento de anticorpo a partir de um extrato de célula periplásmica que compreende uma primeira etapa de cromatografia de troca de cátion e uma segunda etapa de cromatografia de troca aniônica.
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Patent Agency Ranking
公开(公告)号：SG10201408639RA
公开(公告)日：2015-02-27
申请号：SG10201408639R
申请日：2011-02-02
Applicant: UCB PHARMA SA
Inventor： BILGISCHER JEAN-PASCAL PIERRE , BASSETT PHILIP JONATHAN , PEARCE-HIGGINS MARK ROBERT , KENNY ANDREW JOHN
Abstract: The present disclosure relates to a method for the manufacture of recombinant antibody molecules comprising culturing a host cell sample transformed with an expression vector encoding a recombinant antibody molecule; adding an extraction buffer to the sample; and subjecting the sample to a heat treatment step; wherein the pH of the sample is detected after addition of the extraction buffer, and optionally adjusted, to ensure that the pH of the sample is 6 to 9 prior to the heat treatment step.
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公开(公告)号：AU2011284896A1
公开(公告)日：2013-01-24
申请号：AU2011284896
申请日：2011-07-26
Applicant: UCB PHARMA SA
Abstract: The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.
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公开(公告)号：HK1246330A1
公开(公告)日：2018-09-07
申请号：HK18105961
申请日：2018-05-08
Applicant: UCB PHARMA SA
IPC: C07K20060101
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公开(公告)号：SG10201802316VA
公开(公告)日：2018-04-27
申请号：SG10201802316V
申请日：2011-07-26
Applicant: UCB PHARMA SA
Abstract: The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.
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公开(公告)号：SG186957A1
公开(公告)日：2013-02-28
申请号：SG2013001060
申请日：2011-07-26
Applicant: UCB PHARMA SA
Abstract: The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.
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