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公开(公告)号：CO7240426A2
公开(公告)日：2015-04-17
申请号：CO14272157
申请日：2014-12-11
Applicant: UCB PHARMA SA
Abstract: VER PESTAÑA ANEXOS
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公开(公告)号：MX2014012623A
公开(公告)日：2015-01-15
申请号：MX2014012623
申请日：2013-05-13
Applicant: UCB PHARMA SA
Abstract: La presente descripción se refiere a una célula bacteriana gramnegativa recombinante que comprende: a.) un gen spr mutante que codifica una proteína spr que tiene una mutación en uno o más aminoácidos seleccionados del D133, H145, H157, N31, R62, I70 , Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, G147 y R144 y b.) un gen capaz de expresar o sobreexpresar una o más proteínas capaces de facilitar el plegamiento de proteínas, tales como FkpA, Skp, SurA, PPiA y PPiD, en donde la célula tiene actividad de proteína Tsp reducida comparada con una célula en estado natural, los métodos que emplean las células, el uso de las células en la expresión de proteínas en particular anticuerpos, tales como anticuerpos anti Fc Rn y proteínas producidas por los métodos descritos en el presente documento.
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公开(公告)号：AU2013261915B2
公开(公告)日：2017-12-14
申请号：AU2013261915
申请日：2013-05-13
Applicant: UCB PHARMA SA
Abstract: The present disclosure relates to a recombinant gram-negative bacterial cell comprising: a.) a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, I70, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 and G147 and b.) a gene capable of expressing or overexpressing one or more proteins capable of facilitating protein folding, such as FkpA, Skp, SurA, PPiA and PPiD, wherein the cell has reduced Tsp protein activity compared to a wild-type cell, methods employing the cells, use of the cells in the expression of proteins in particular antibodies, such as anti Fc Rn antibodies and proteins made by the methods described herein.
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Patent Agency Ranking
公开(公告)号：CA2872328C
公开(公告)日：2020-10-13
申请号：CA2872328
申请日：2013-05-13
Applicant: UCB PHARMA SA
Abstract: The present disclosure relates to a recombinant gram-negative bacterial cell comprising: a.) a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, I70, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 and G147 and b.) a gene capable of expressing or overexpressing one or more proteins capable of facilitating protein folding, such as FkpA, Skp, SurA, PPiA and PPiD, wherein the cell has reduced Tsp protein activity compared to a wild-type cell, methods employing the cells, use of the cells in the expression of proteins in particular antibodies, such as anti Fc Rn antibodies and proteins made by the methods described herein.
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公开(公告)号：MY166223A
公开(公告)日：2018-06-22
申请号：MYPI2014703261
申请日：2013-05-13
Applicant: UCB PHARMA SA
Abstract: The present disclosure relates to a recombinant gram-negative bacterial cell comprising : a.) a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, 170, Q73, C94, S95, V98, Q99, R100, L108, Y115, L136, G140, R144 and G147 and b.) a gene capable of expressing or overexpressing one or more proteins capable of facilitating protein folding, such as FkpA, Skp, SurA, PPiA and PPiD, wherein the cell has reduced Tsp protein activity compared to a wild-type cell, methods employing the cells, use of the cells in the expression of proteins in particular antibodies, such as anti FeRn antibodies and proteins made by the methods described herein. Figure 4.
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公开(公告)号：AU2013261915A1
公开(公告)日：2014-12-18
申请号：AU2013261915
申请日：2013-05-13
Applicant: UCB PHARMA SA
Abstract: The present disclosure relates to a recombinant gram-negative bacterial cell comprising: a.) a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, I70, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 and G147 and b.) a gene capable of expressing or overexpressing one or more proteins capable of facilitating protein folding, such as FkpA, Skp, SurA, PPiA and PPiD, wherein the cell has reduced Tsp protein activity compared to a wild-type cell, methods employing the cells, use of the cells in the expression of proteins in particular antibodies, such as anti Fc Rn antibodies and proteins made by the methods described herein.
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公开(公告)号：SG11201406474RA
公开(公告)日：2014-11-27
申请号：SG11201406474R
申请日：2013-05-13
Applicant: UCB PHARMA SA
Abstract: The present disclosure relates to a recombinant gram-negative bacterial cell comprising: a) a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, I70, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 and G147 and b) a gene capable of expressing or overexpressing one or more proteins capable of facilitating protein folding, such as FkpA, Skp, SurA, PPiA and PPiD, wherein the cell has reduced Tsp protein activity compared to a wild-type cell, methods employing the cells, use of the cells in the expression of proteins in particular antibodies, such as anti FcRn antibodies and proteins made by the methods described herein.
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公开(公告)号：CA2872328A1
公开(公告)日：2013-11-21
申请号：CA2872328
申请日：2013-05-13
Applicant: UCB PHARMA SA
Abstract: The present disclosure relates to a recombinant gram-negative bacterial cell comprising: a.) a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, I70, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 and G147 and b.) a gene capable of expressing or overexpressing one or more proteins capable of facilitating protein folding, such as FkpA, Skp, SurA, PPiA and PPiD, wherein the cell has reduced Tsp protein activity compared to a wild-type cell, methods employing the cells, use of the cells in the expression of proteins in particular antibodies, such as anti Fc Rn antibodies and proteins made by the methods described herein.
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