公开(公告)号：JPS6416589A

公开(公告)日：1989-01-20

申请号：JP13003388

申请日：1988-05-27

Applicant: UCB SA

Inventor： BOREN ARETSUKUSU ,  GOBEERU JIYAN ,  BURUFUEERU ERUNSUTO

IPC: C12N15/09 ,  A61K38/00 ,  C07K4/12 ,  C07K14/775 ,  C12N1/16 ,  C12N1/20 ,  C12N5/10 ,  C12N15/00 ,  C12N15/12 ,  C12P21/00 ,  C12P21/02 ,  C12R1/19 ,  C12R1/865

Abstract: The present invention provides recombinant DNA sequences comprising a sequence which codes for human proapolipoprotein A-I wherein part of the natural coding sequence has been replaced by a DNA fragment coding for the same amino acids but consisting of a different nucleotide sequence such as to reduce or prevent formation of hairpins, cloning and expression vectors containing these DNA sequences, cell cultures or microorganisms transformed with these expression vectors and processes using the same for the production of proapolipoprotein A-I.