公开(公告)号：JPH06220026A

公开(公告)日：1994-08-09

申请号：JP19870292

申请日：1992-07-24

Applicant: UCB SA

Inventor： BERENDO YAN BAN KEUREN ,  SORO GOORUDOSUTAIN ,  ERITSUKU KOSEMENTO ,  JIYAN GOBEERU ,  ERUNSUTO BUYURUFUERUTO

IPC: A61K31/53 ,  A61K31/5377 ,  A61K31/541 ,  A61P11/00 ,  A61P11/06 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/26 ,  A61P25/28 ,  A61P29/00 ,  C07D251/12 ,  C07D251/14 ,  C07D251/16 ,  C07D251/18 ,  C07D251/22 ,  C07D401/04 ,  C07D403/04 ,  C07D411/04 ,  C07D413/04 ,  C07D417/04 ,  C07D498/08

Abstract: New cyclopropylamino-1,3,5-triazines and their salts, processes for their preparation and therapeutic compositions. These compounds correspond to the formula in which R1 = alkyl, cycloalkyl or alkylcycloalkyl, R2 = bis(2-hydroxyethyl)amino, 3-hydroxy-1-azetidinyl, 3-methoxy-1-azetidinyl, 3-oxo-1-azetidinyl, morpholino, 4-hydroxypiperidino, thiomorpholino, thiomorpholino S-oxide, thiomorpholino S,S-dioxide, 3-thiazolidinyl, 3-thiazolidinyl S-oxide, 3-thiazolidinyl S,S-dioxide or 8-oxa-3-azabicyclo[3.2.1]oct-3-yl. These compounds are useful in the treatment of disorders associated with Alzheimer's disease, Alzheimer-type senile dementias and all evolutive cognitive pathologies and in the treatment of depression, anxiety, mood disorders, inflammatory phenomena and asthma.

公开(公告)号：JPS63132876A

公开(公告)日：1988-06-04

申请号：JP27814487

申请日：1987-11-02

Applicant: UCB SA

Inventor： ERITSUKU KOSEMENTO ,  JIYAN PIEERU GEERUTSU ,  JIYAN GOBEERU ,  FUIRITSUPU MISHIERU

IPC: A61K31/415 ,  A61K31/4164 ,  A61K31/495 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D233/54 ,  C07D233/58 ,  C07D233/64 ,  C07D405/06 ,  C07D413/06