公开(公告)号：JPH02108675A

公开(公告)日：1990-04-20

申请号：JP21054789

申请日：1989-08-15

Applicant: UCB SA

Inventor： ERITSUKU KOSUMAN ,  JIYAN GOBEERU ,  RORANDO BOIDEN ,  JIYATSUKU MACHIYUU

IPC: C07D413/04 ,  A61K31/53 ,  A61K31/535 ,  A61K31/5377 ,  A61P21/02 ,  A61P25/28 ,  A61P27/06 ,  C07D251/18

Abstract: New 2-amino-4-morpholino-6-propyl-1,3,5-triazines having the formula (I) wherein R1 is hydrogen, alkyl, aralkyl or acetyl, R2 is hydroxyl, hydroxyalkyl, alkoxyalkyl, dialkylamino, arylhydroxyalkyl, (hydroxy-cycloalkyl)alkyl, alkanoyloxyalkyl, benzoyloxyalkyl, phenylacetyloxyalkyl, aminocarbonyloxyalkyl, COR3 or CONR4R5, or NR1R2=(hydroxyalkyl)alkyleneimino, R3=alkyl, aryl, haloaryl, alkylaryl, alkoxyaryl, aralkyl or aryloxy, R4=R5=hydrogen or alkyl, alkyl, alkoxy and alkanoyloxy having 1 to 4 carbon atoms, cycloalkyl and alkyleneimino having 4 to 6 carbon atoms. Moreover, when R1 is acetyl, R2 is acetoxyalkyl. Processes for the preparation thereof and pharmaceutical compositions containing the same are also given. In particular, these compounds are useful for the treatment of cognitive and behavioral disorders associated with aging and dementia syndromes, e.g. those associated with Alzheimer's disease.

公开(公告)号：JPH0770082A

公开(公告)日：1995-03-14

申请号：JP11296094

申请日：1994-05-26

Applicant: UCB SA

Inventor： FUIRITSUPU MISHIERU ,  ERITSUKU KOSUMAN ,  JIYAN GOBEERU ,  ERUNSUTO BURUFUERUTO

IPC: A61K31/415 ,  A61K31/4164 ,  A61K31/4174 ,  A61K31/4178 ,  A61P27/02 ,  A61P27/06 ,  C07D233/54 ,  C07D233/56 ,  C07D233/64 ,  C07D403/10

公开(公告)号：JPH072816A

公开(公告)日：1995-01-06

申请号：JP4254794

申请日：1994-03-14

Applicant: UCB SA

Inventor： ERITSUKU KOSUMAN ,  GIYUI BODOUSON ,  JIYAN GOBEERU

IPC: C07D295/06 ,  A61K31/495 ,  A61P11/06 ,  A61P25/20 ,  A61P25/22 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07B53/00 ,  C07D295/04 ,  C07D295/073 ,  C07D295/08 ,  C07D295/088 ,  C07D295/22 ,  C07D295/26