公开(公告)号：JPS60252461A

公开(公告)日：1985-12-13

申请号：JP10252985

申请日：1985-05-14

Applicant: UCB SA

Inventor： JIYAN GOBERU ,  JIYAN PIEERU GEERUTSU ,  GII BODOSON

IPC: C07D207/26 ,  A61K31/40 ,  A61K31/4015 ,  A61P7/06 ,  A61P9/00 ,  A61P9/10 ,  C07D207/12 ,  C07D207/27 ,  C07D207/277 ,  C07D295/185

Abstract: (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide, its preparation and pharmaceutical compositions containing the same. It can be prepared either by reacting (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetic acid successively with an alkyl haloformate and with ammonia, or, by cyclizing an (S)-2-amino-butanamide of the formula X-CH2CH2-NHCH (C2H5)CONH2 wherein Y is a -CH2-radical when X represents a ZOOC-radical and Y is a -CO- radical when X represents a HalCH2-radical, Z being a C1-C4 alkyl radical and Hal a halogen atom. This laevorotatory enantiomer has been found to have significantly higher protective activity against hypoxia and ischemia than the corresponding racemate.

公开(公告)号：JPS60255764A

公开(公告)日：1985-12-17

申请号：JP10253085

申请日：1985-05-14

Applicant: UCB SA

Inventor： JIYAN GOBERU ,  KORUNERIU GIURUGEA ,  JIYAN PIEERU GEERUTSU ,  GII BODOSON

IPC: C07D207/26 ,  A61K31/40 ,  A61K31/4015 ,  A61P25/28 ,  C07D207/27 ,  C07D295/185