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公开(公告)号:WO2006123122A2
公开(公告)日:2006-11-23
申请号:PCT/GB2006001781
申请日:2006-05-16
Applicant: UCB SA , STAMPS ALASDAIR CRAIG
Inventor: STAMPS ALASDAIR CRAIG
IPC: A61K39/395 , A61K38/17 , A61P35/00 , G01N33/574
CPC classification number: G01N33/57484 , A61K38/1709 , A61K39/395 , G01N2500/00 , G01N2800/52
Abstract: The present invention relates to new uses of PSK-I in the diagnosis, screening, treatment and prophylaxis of ovarian and lung cancer. The invention also provides compositions comprising PSK-I, including vaccines, antibodies that are immunospecific for PSK-I and agents which interact with or modulate the expression or activity of PSK-I or which modulate the expression of the nucleic acid which codes for PSK-I .
Abstract translation: 本发明涉及PSK-1在诊断,筛选,治疗和预防卵巢癌和肺癌中的新用途。 本发明还提供包含PSK-1的组合物,包括疫苗,对PSK-1具有免疫特异性的抗体和与PSK-1的表达或活性相互作用或调节PSK-1的表达或活性或调节编码PSK- 一世 。
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公开(公告)号:ES2279801T3
公开(公告)日:2007-09-01
申请号:ES01905965
申请日:2001-02-21
Applicant: UCB SA
IPC: A61K38/17 , G01N33/50 , A61K31/7088 , A61K31/7105 , A61K38/00 , A61K39/00 , A61K39/395 , A61K47/42 , A61K48/00 , A61K49/00 , A61K51/10 , A61P35/00 , C07K14/47 , C07K16/18 , C07K16/32 , C12M1/00 , C12N1/21 , C12N15/09 , C12N15/12 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/574 , G01N33/577
Abstract: El uso de un anticuerpo capaz de unión inmunoespecífica a BST-2 (BCMP-17) o uno de sus fragmentos o derivados que comprende el dominio de unión del anticuerpo, en la fabricación de un medicamento para el tratamiento del cáncer de mama.
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公开(公告)号:AT352311T
公开(公告)日:2007-02-15
申请号:AT01905965
申请日:2001-02-21
Applicant: UCB SA
Inventor: BOYD ROBERT SIMON , STAMPS ALASDAIR CRAIG , TERRETT JONATHAN ALEXANDER
IPC: G01N33/50 , A61K31/7088 , A61K31/7105 , A61K38/00 , A61K39/00 , A61K39/395 , A61K47/42 , A61K48/00 , A61K49/00 , A61K51/10 , A61P35/00 , C07K14/47 , C07K16/32 , C12M1/00 , C12N1/21 , C12N15/09 , C12N15/12 , C12Q1/68 , G01N33/15 , G01N33/566 , G01N33/574 , G01N33/577 , A61K38/17 , C07K16/18 , G01N33/53
Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of breast cancer, for monitoring the effectiveness of breast cancer treatment, and for drug development.
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公开(公告)号:DK1240313T3
公开(公告)日:2006-11-27
申请号:DK00985677
申请日:2000-12-21
Applicant: UCB SA
Inventor: MCKENZIE EDWARD ALEXANDER , STAMPS ALASDAIR CRAIG , TERRETT JONATHAN ALEXANDER , TYSON KERRY LOUISE
IPC: C12N9/24 , C12N15/09 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/10 , A61P7/02 , A61P9/08 , A61P11/06 , A61P17/02 , A61P17/16 , A61P19/02 , A61P25/00 , A61P25/28 , A61P27/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/06 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10
Abstract: The present invention provides a homologue to heparanase which is present in three splice variants.
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公开(公告)号:AT334194T
公开(公告)日:2006-08-15
申请号:AT00985677
申请日:2000-12-21
Applicant: UCB SA
Inventor: MCKENZIE EDWARD ALEXANDER , STAMPS ALASDAIR CRAIG , TERRETT JONATHAN ALEXANDER , TYSON KERRY LOUISE
IPC: C12N15/09 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/10 , A61P7/02 , A61P9/08 , A61P11/06 , A61P17/02 , A61P17/16 , A61P19/02 , A61P25/00 , A61P25/28 , A61P27/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/06 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/24
Abstract: The present invention provides a homologue to heparanase which is present in three splice variants.
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公开(公告)号:DE60126248D1
公开(公告)日:2007-03-15
申请号:DE60126248
申请日:2001-02-21
Applicant: UCB SA
Inventor: BOYD ROBERT SIMON , STAMPS ALASDAIR CRAIG , TERRETT ALEXANDER
IPC: A61K38/17 , G01N33/50 , A61K31/7088 , A61K31/7105 , A61K38/00 , A61K39/00 , A61K39/395 , A61K47/42 , A61K48/00 , A61K49/00 , A61K51/10 , A61P35/00 , C07K14/47 , C07K16/18 , C07K16/32 , C12M1/00 , C12N1/21 , C12N15/09 , C12N15/12 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/574 , G01N33/577
Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of breast cancer, for monitoring the effectiveness of breast cancer treatment, and for drug development.
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公开(公告)号:DE60126248T2
公开(公告)日:2007-07-05
申请号:DE60126248
申请日:2001-02-21
Applicant: UCB SA
Inventor: BOYD ROBERT SIMON , STAMPS ALASDAIR CRAIG , TERRETT ALEXANDER
IPC: A61K38/17 , G01N33/50 , A61K31/7088 , A61K31/7105 , A61K38/00 , A61K39/00 , A61K39/395 , A61K47/42 , A61K48/00 , A61K49/00 , A61K51/10 , A61P35/00 , C07K14/47 , C07K16/18 , C07K16/32 , C12M1/00 , C12N1/21 , C12N15/09 , C12N15/12 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/574 , G01N33/577
Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of breast cancer, for monitoring the effectiveness of breast cancer treatment, and for drug development.
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公开(公告)号:ES2269211T3
公开(公告)日:2007-04-01
申请号:ES00985677
申请日:2000-12-21
Applicant: UCB SA
Inventor: MCKENZIE EDWARD ALEXANDER , STAMPS ALASDAIR CRAIG , TERRETT JONATHAN ALEXANDER , TYSON KERRY LOUISE
IPC: C12N9/24 , C12N15/09 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/10 , A61P7/02 , A61P9/08 , A61P11/06 , A61P17/02 , A61P17/16 , A61P19/02 , A61P25/00 , A61P25/28 , A61P27/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/06 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10
Abstract: Un polipéptido que: a) comprende la secuencia de aminoácidos de la Sec. ID No. 2 (Figura 1), que comienza en el residuo 1, 2, 11, 12 o 43; b) comprende la secuencia de aminoácidos de la Sec. ID No. 4 (Figura 2), que comienza en el residuo 1, 2, 11, 12 o 43; c) comprende la secuencia de aminoácidos de la Sec. ID No. 6 (Figura 3), que comienza en el residuo 1, 2, 11, 12 o 43; o d) es un derivado de por lo menos 40 aminoácidos de longitud que tiene una o más sustituciones, supresiones o inserciones de aminoácidos en relación con un polipéptido definido en a), b) o c) anteriores, siendo dicho derivado por lo menos 80% idéntico a una secuencia de aminoácidos de dicho polipéptido; o e) es un fragmento de un polipéptido definido en a), b) o c) anteriores, el cual tiene al menos 40 aminoácidos de longitud o un fragmento de un polipéptido definido en d) anterior, el cual tiene al menos 50 aminoácidos de longitud.
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