公开(公告)号：CA2759698C

公开(公告)日：2019-01-15

申请号：CA2759698

申请日：2010-04-23

Applicant: UNIV CALIFORNIA

Inventor： SHAW ROBIN ,  HONG TING-TING ,  SMYTH JAMES

IPC: C12Q1/68 ,  C12Q1/6809 ,  G01N33/48 ,  G01N33/53

Abstract: The present disclosure provides methods involving use of BIN1 expression levels, in heart tissue, in evaluating the risk of cardiac mortality in a patient diagnosed with congestive heart failure. The methods finds use in evaluating patients who are heart transplant candidates, as well as in assessing efficacy of treatment in congestive heart failure patients.

公开(公告)号：CA2814702C

公开(公告)日：2019-05-28

申请号：CA2814702

申请日：2011-10-20

Applicant: UNIV CALIFORNIA

Inventor： SHAW ROBIN ,  HONG TING-TING

IPC: G01N33/48 ,  C07K14/435

Abstract: The present disclosure provides methods involving use of BIN1 protein levels in biological fluid of a subject in evaluating cardiac health of the subject. The method provided herein may be used to predict a risk of a poor outcome in a subject. The methods also find use in evaluating subjects for assessing patients diagnosed with heart failure. These methods are also useful in assessing therapy options and efficacy of treatment in heart failure patients.

公开(公告)号：WO2010124240A3

公开(公告)日：2011-03-31

申请号：PCT/US2010032282

申请日：2010-04-23

Applicant: UNIV CALIFORNIA ,  SHAW ROBIN ,  HONG TING-TING ,  SMYTH JAMES

Inventor： SHAW ROBIN ,  HONG TING-TING ,  SMYTH JAMES

IPC: C12Q1/68 ,  C12N15/12 ,  G01N33/68

CPC classification number: C12Q1/6883 ,  C07K14/4716 ,  C07K14/4747 ,  G01N33/6893 ,  G01N2333/4703 ,  G01N2800/325 ,  G01N2800/56

Abstract: The present disclosure provides methods involving use of BIN1 expression levels, in heart tissue, in evaluating the risk of cardiac mortality in a patient diagnosed with congestive heart failure. The methods finds use in evaluating patients who are heart transplant candidates, as well as in assessing efficacy of treatment in congestive heart failure patients.

Abstract translation: 本公开提供涉及在心脏组织中使用BIN1表达水平评估诊断为充血性心力衰竭的患者的心脏死亡风险的方法。 该方法可用于评估心脏移植候选患者，以及评估治疗充血性心力衰竭患者的疗效。

公开(公告)号：EP2630490A4

公开(公告)日：2014-04-16

申请号：EP11835168

申请日：2011-10-20

Applicant: UNIV CALIFORNIA

Inventor： SHAW ROBIN ,  HONG TING-TING

IPC: G01N33/50 ,  C07K14/435 ,  G01N33/68

CPC classification number: G01N33/6887 ,  G01N33/6893 ,  G01N2800/325 ,  G01N2800/56

Abstract: The present disclosure provides methods involving use of BIN1 protein levels in biological fluid of a subject in evaluating cardiac health of the subject. The method provided herein may be used to predict a risk of a poor outcome in a subject. The methods also find use in evaluating subjects for assessing patients diagnosed with heart failure. These methods are also useful in assessing therapy options and efficacy of treatment in heart failure patients.

公开(公告)号：EP2421994A4

公开(公告)日：2012-11-07

申请号：EP10767856

申请日：2010-04-23

Applicant: UNIV CALIFORNIA

Inventor： SHAW ROBIN ,  HONG TING-TING ,  SMYTH JAMES

IPC: C12Q1/68 ,  C12N15/12 ,  G01N33/68

CPC classification number: C12Q1/6883 ,  C07K14/4716 ,  C07K14/4747 ,  G01N33/6893 ,  G01N2333/4703 ,  G01N2800/325 ,  G01N2800/56

公开(公告)号：CA2814702A1

公开(公告)日：2012-04-26

申请号：CA2814702

申请日：2011-10-20

Applicant: UNIV CALIFORNIA

Inventor： SHAW ROBIN ,  HONG TING-TING

IPC: G01N33/48 ,  C07K14/435

Abstract: The present disclosure provides methods involving use of BIN1 protein levels in biological fluid of a subject in evaluating cardiac health of the subject. The method provided herein may be used to predict a risk of a poor outcome in a subject. The methods also find use in evaluating subjects for assessing patients diagnosed with heart failure. These methods are also useful in assessing therapy options and efficacy of treatment in heart failure patients.

公开(公告)号：CA2759698A1

公开(公告)日：2010-10-28

申请号：CA2759698

申请日：2010-04-23

Applicant: UNIV CALIFORNIA

Inventor： SHAW ROBIN ,  HONG TING-TING ,  SMYTH JAMES

IPC: C12Q1/68 ,  C12N15/12 ,  G01N33/68

Abstract: The present disclosure provides methods involving use of BIN1 expression levels, in heart tissue, in evaluating the risk of cardiac mortality in a patient diagnosed with congestive heart failure. The methods finds use in evaluating patients who are heart transplant candidates, as well as in assessing efficacy of treatment in congestive heart failure patients.