公开(公告)号：WO03085376A2

公开(公告)日：2003-10-16

申请号：PCT/US0310490

申请日：2003-04-03

Applicant: UNIV CALIFORNIA

Inventor： CHUCK ROY S ,  MCDONNELL PETER JOHN ,  SHEHADA RAMEZ EMILE NECOLA

IPC: A61B5/00 ,  A61B5/103 ,  G01J3/44 ,  G01N21/64 ,  G01N21/71 ,  G01N

CPC classification number: A61B5/0059 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/411 ,  A61B5/441 ,  A61B5/7267 ,  G01J3/4406 ,  G01N21/64 ,  G01N21/6402 ,  G01N21/6408 ,  G01N21/645 ,  G01N21/718 ,  G01N2021/1782 ,  G01N2021/6417 ,  G01N2201/06113 ,  G01N2201/0633 ,  G01N2201/0697 ,  G01N2201/1296

Abstract: Methods and systems for the quantitative and qualitative determination of one or more exogenous substances within a material are described. A flow of fluorescence-exciting/ablative energy (e.g., laser pulse(s), preferably in the ultraviolet region (e.g. 193-nm)), is directed onto the material to ablate a thin layer (e.g. ≈ 0.3-µm) of the material using photochemical decomposition. Simultaneously, the laser energy induces the fluorescence of the substance(s) of interest within the ablated layer of the material. The fluorescence emitted by the substance(s) of interest is then received by a device (e.g., a spectrometer), which measures the spectrum (i.e. intensity versus wavelength) of the received fluorescence. The fluorescence spectra are then transmitted to a spectral processing device (e.g., a microprocessor or computer) which is programmed or otherwise adapted to determine, on the basis of the fluoroscence spectra, whether the substance(s) of interest is/are present in the material and/or the concentration at which the substance(s) of interest is/are present in the material. This process may be repeated for each layer of the material to determine the concentration gradient of the substance(s) of interest in the material.

Abstract translation: 描述了用于定量和定性测定材料内的一种或多种外源物质的方法和系统。 荧光激发/消融能量（例如，优选在紫外区域（例如193nm）的激光脉冲））的流动被引导到材料上以消融所述材料的薄层（例如≈0.3μm） 材料使用光化学分解。 同时，激光能量在材料的烧蚀层内感应感兴趣的物质的荧光。 由感兴趣的物质发射的荧光然后由测量接收的荧光的光谱（即强度对波长）的装置（例如，光谱仪）接收。 然后将荧光光谱传输到频谱处理装置（例如，微处理器或计算机），该处理装置被编程或以其他方式适于基于荧光光谱确定目的物质是否存在于 材料和/或感兴趣物质存在于材料中的浓度。 可以针对材料的每层重复该过程以确定材料中感兴趣的物质的浓度梯度。

公开(公告)号：AU2003260583A8

公开(公告)日：2003-10-20

申请号：AU2003260583

申请日：2003-04-03

Applicant: UNIV CALIFORNIA

Inventor： CHUCK ROY S ,  MCDONNELL PETER JOHN ,  SHEHADA RAMEZ EMILE NECOLA

IPC: A61B5/00 ,  A61B5/103 ,  G01J3/44 ,  G01N21/64 ,  G01N21/71 ,  A61B6/00 ,  A61B18/20

Abstract: Methods and systems for determination of one or more substances within a material are described. A flow of fluorescence-exciting/ablative energy (e.g., laser pulse(s), preferably in the ultraviolet region (e.g. 193-nm)), is directed onto the material to ablate a thin layer of the material using photochemical decomposition. Simultaneously, the laser energy induces fluorescence of the substance(s) within the ablated layer of the material. The fluorescence emitted by the substance(s) is then received by a device, which measures the spectrum of the received fluorescence. The fluorescence spectra are then transmitted to a spectral processing device adapted to determine, on the basis of the fluorescence spectra, whether the substance(s) of interest is/are present in the material and/or the concentration at which the substance(s) of interest is/are present in the material. This process may be repeated for each layer of the material to determine the concentration gradient of the substance(s) of interest in the material.

公开(公告)号：AU2003260583A1

公开(公告)日：2003-10-20

申请号：AU2003260583

申请日：2003-04-03

Applicant: UNIV CALIFORNIA

Inventor： CHUCK ROY S ,  MCDONNELL PETER JOHN ,  SHEHADA RAMEZ EMILE NECOLA

IPC: A61B5/00 ,  A61B5/103 ,  G01J3/44 ,  G01N21/64 ,  G01N21/71

Abstract: Methods and systems for determination of one or more substances within a material are described. A flow of fluorescence-exciting/ablative energy (e.g., laser pulse(s), preferably in the ultraviolet region (e.g. 193-nm)), is directed onto the material to ablate a thin layer of the material using photochemical decomposition. Simultaneously, the laser energy induces fluorescence of the substance(s) within the ablated layer of the material. The fluorescence emitted by the substance(s) is then received by a device, which measures the spectrum of the received fluorescence. The fluorescence spectra are then transmitted to a spectral processing device adapted to determine, on the basis of the fluorescence spectra, whether the substance(s) of interest is/are present in the material and/or the concentration at which the substance(s) of interest is/are present in the material. This process may be repeated for each layer of the material to determine the concentration gradient of the substance(s) of interest in the material.