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1.发明公开CONDUCTIVE BIOMATERIAL FOR ENHANCEMENT OF CONDUCTION IN VITRO AND IN VIVO 审中-公开LEITFÄHIGES生物材料ZUR VERBESSERUNG EINERLEITFÄHIGKEITIN VITRO UND VIVO
公开(公告)号：EP2953651A4
公开(公告)日：2017-01-25
申请号：EP14748519
申请日：2014-02-04
Applicant: UNIV HEALTH NETWORK
Inventor： LI REN-KE
IPC: A61K50/00 , A61K9/10 , A61K31/785 , A61K31/787
CPC classification number: A61K31/787 , A61K9/0024 , A61K31/785 , A61K47/36 , A61K47/61 , A61K47/6435 , A61K47/6903 , A61L27/26 , A61L27/50 , A61L31/041 , A61L31/14 , A61L2400/06 , A61L2430/20 , C08G61/124 , C08G2261/128 , C08G2261/3221 , C08L89/06 , C08L5/08
Abstract: A biocompatible, electrically conductive biomaterial capable of earn carrying the electrical potential of a cardiac impulse and comprising (1) a conductive polymer such as polyaniline, polypyrrole or polythiophene, and (ii) a biocompatible component such as a polysaccharide, a protein, or a polypeptide, in particular chitosan or gelatin, is described. The material can take the form of a hydrogel, membrane, sheet or mesh. It can be used to restore or improve electrical impulse propagation across damaged tissue or scar region of the myocardium, in particular in the ti treatment of myocardial infarction and arrhythmia.
Abstract translation: 能够产生携带心脏脉冲的电势的生物相容的导电生物材料，其包括（1）导电聚合物，例如聚苯胺，聚吡咯或聚噻吩，和（ii）生物相容性成分如多糖，蛋白质或 多肽，特别是壳聚糖或明胶。 该材料可以采取水凝胶，膜，片或网的形式。 它可用于恢复或改善穿过受损组织或心肌瘢痕区域的电脉冲传播，特别是在心肌梗死和心律失常的治疗中。
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公开(公告)号：AU2018308734B2
公开(公告)日：2024-05-30
申请号：AU2018308734
申请日：2018-07-27
Applicant: UNIV HEALTH NETWORK
Inventor： LI REN-KE
Abstract: The present disclosure relates to a biocompatible, electrically conductive biomaterial capable of carrying the electrical potential of a cardiac impulse. The biomaterial comprises a conductive polymer and a biocompatible component. The conductive polymer comprising an aminomethoxybenzoic acid (AMBA) polymer. The present disclosure also relates to treatments, uses and devices using the biocompatible, electrically conductive biomaterial.
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公开(公告)号：AU2018308734A8
公开(公告)日：2020-03-12
申请号：AU2018308734
申请日：2018-07-27
Applicant: UNIV HEALTH NETWORK
Inventor： LI REN-KE
Abstract: The present disclosure relates to a biocompatible, electrically conductive biomaterial capable of carrying the electrical potential of a cardiac impulse. The biomaterial comprises a conductive polymer and a biocompatible component. The conductive polymer comprising an aminomethoxybenzoic acid (AMBA) polymer. The present disclosure also relates to treatments, uses and devices using the biocompatible, electrically conductive biomaterial.
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公开(公告)号：CA2937019C
公开(公告)日：2020-12-15
申请号：CA2937019
申请日：2014-02-04
Applicant: UNIV HEALTH NETWORK
Inventor： LI REN-KE
IPC: A61K50/00 , A61K9/10 , A61K31/785 , A61K31/787
Abstract: There is described herein a biocompatible material, preferably for use with cardiac tissue. The material comprises a conductive polymer and a biocompatible component, wherein the conductive polymer is a polypyrrole-based polymer; the biocompatible component is chitosan; and the material further comprises a crosslinking agent and the conductive polymer and the biocompatible component are chemically conjugated to form a matrix throughout to form the material which is a homogenous hydrogel.
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公开(公告)号：CA2937019A1
公开(公告)日：2014-08-14
申请号：CA2937019
申请日：2014-02-04
Applicant: UNIV HEALTH NETWORK
Inventor： LI REN-KE
IPC: A61K50/00 , A61K9/10 , A61K31/785 , A61K31/787
Abstract: A biocompatible, electrically conductive biomaterial capable of earn carrying the electrical potential of a cardiac impulse and comprising (l) a conductive polymer such as polyaniline, polypyrrole or polythiophene, and (ii) a biocompatible component such as a polysaccharide, a protein, or a polypeptide, in particular chitosan or gelatin, is described. The material can take the form of a hydrogel, membrane, sheet or mesh. It can be used to restore or improve electrical impulse propagation across damaged tissue or scar region of the myocardium, in particular in the ti treatment of myocardial infarction and arrhythmia.
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Patent Agency Ranking
公开(公告)号：CA2719855A1
公开(公告)日：2012-05-02
申请号：CA2719855
申请日：2010-11-02
Applicant: UNIV HEALTH NETWORK
Abstract: The present disclosure relates to temperature sensitive hydrogel and block copolymers, processes for the production thereof, and pharmaceutical conjugates using the copolymers.
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公开(公告)号：SG11202000512RA
公开(公告)日：2020-02-27
申请号：SG11202000512R
申请日：2018-07-27
Applicant: UNIV HEALTH NETWORK
Inventor： LI REN-KE
Abstract: The present disclosure relates to a biocompatible, electrically conductive biomaterial capable of carrying the electrical potential of a cardiac impulse. The biomaterial comprises a conductive polymer and a biocompatible component. The conductive polymer comprising an aminomethoxybenzoic acid (AMBA) polymer. The present disclosure also relates to treatments, uses and devices using the biocompatible, electrically conductive biomaterial.
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公开(公告)号：ES2795651T3
公开(公告)日：2020-11-24
申请号：ES14748519
申请日：2014-02-04
Applicant: UNIV HEALTH NETWORK
Inventor： LI REN-KE
Abstract: Un material biocompatible que comprende un polímero conductor y un componente biocompatible, en donde el polímero conductor es un polímero basado en polipirrol; el componente biocompatible es el quitosano; y el material comprende además un agente de reticulación y el polímero conductor y el componente biocompatible se conjugan químicamente para formar totalmente una matriz para formar el material que es un hidrogel homogéneo.
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9.发明专利
公开(公告)号：AU2018308734A1
公开(公告)日：2020-03-05
申请号：AU2018308734
申请日：2018-07-27
Applicant: UNIV HEALTH NETWORK
Inventor： LI REN-KE
Abstract: The present disclosure relates to a biocompatible, electrically conductive biomaterial capable of carrying the electrical potential of a cardiac impulse. The biomaterial comprises a conductive polymer and a biocompatible component. The conductive polymer comprising an aminomethoxybenzoic acid (AMBA) polymer. The present disclosure also relates to treatments, uses and devices using the biocompatible, electrically conductive biomaterial.
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公开(公告)号：CA3070239A1
公开(公告)日：2019-01-31
申请号：CA3070239
申请日：2018-07-27
Applicant: UNIV HEALTH NETWORK
Inventor： LI REN-KE
Abstract: The present disclosure relates to a biocompatible, electrically conductive biomaterial capable of carrying the electrical potential of a cardiac impulse. The biomaterial comprises a conductive polymer and a biocompatible component. The conductive polymer comprising an aminomethoxybenzoic acid (AMBA) polymer. The present disclosure also relates to treatments, uses and devices using the biocompatible, electrically conductive biomaterial.
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