公开(公告)号：WO2014191837A2

公开(公告)日：2014-12-04

申请号：PCT/IB2014001748

申请日：2014-05-05

Applicant: UNIV HEALTH NETWORK

Inventor： NANTHAKUMAR KUMARASWAMY

IPC: A61K31/4178

CPC classification number: A61K31/4178 ,  A61K31/422 ,  A61K45/06 ,  A61K2300/00

Abstract: The present description relates to methods of administering effective amounts of an anti-arrhythmic agent, e.g., dantrolene, azumolene or a pharmaceutically acceptable salt thereof, for the acute treatment of cardiac arrhythmias, e.g., atrial fibrillation, premature ventricular contraction, ventricular tachycardia or ventricular fibrillation, and prevention of subsequent cardiac arrhythmias, wherein the methods effectuate a reduction in morbidity and mortality.

Abstract translation: 本说明书涉及施用有效量的抗心律失常药物（例如丹曲林，azumolene或其药学上可接受的盐）用于急性治疗心律失常的方法，例如心房颤动，室性早搏，室性心动过速或室性心律失常 原纤维化和预防随后的心律失常，其中所述方法降低发病率和死亡率。

公开(公告)号：CA2949143C

公开(公告)日：2021-10-12

申请号：CA2949143

申请日：2014-05-16

Applicant: UNIV HEALTH NETWORK

Inventor： NANTHAKUMAR KUMARASWAMY ,  DOWNAR EUGENE ,  MASSE STEPHANE

IPC: A61B5/366 ,  A61B5/283 ,  A61B5/287 ,  A61B5/363

Abstract: Various embodiments are described herein for a system and a method for identifying the arrhythmogenic circuit of a patient or subject. In one embodiment, the method comprises obtaining data for electrograms recorded at various locations of the heart while programmed ventricular pacing with extra stimuli was performed, obtaining decrement values for at least two different locations of the heart using the recorded electrograms, generating at least a portion of a decrement map using the decrement values, and identifying the arrhythmogenic circuit based on electrograms having significant decremental properties.

公开(公告)号：CA2949143A1

公开(公告)日：2014-11-20

申请号：CA2949143

申请日：2014-05-16

Applicant: UNIV HEALTH NETWORK

Inventor： NANTHAKUMAR KUMARASWAMY ,  DOWNAR EUGENE ,  MASSE STEPHANE

IPC: A61B5/366 ,  A61B5/363

Abstract: Various embodiments are described herein for a system and a method for identifying the arrhythmogenic circuit of a patient or subject. In one embodiment, the method comprises obtaining data for electrograms recorded at various locations of the heart while programmed ventricular pacing with extra stimuli was performed, obtaining decrement values for at least two different locations of the heart using the recorded electrograms, generating at least a portion of a decrement map using the decrement values, and identifying the arrhythmogenic circuit based on electrograms having significant decremental properties.

公开(公告)号：CA2946253A1

公开(公告)日：2014-12-04

申请号：CA2946253

申请日：2014-05-05

Applicant: UNIV HEALTH NETWORK

Inventor： NANTHAKUMAR KUMARASWAMY

IPC: A61K31/4178 ,  A61K31/422 ,  A61P9/00 ,  A61P9/06

Abstract: The present description relates to methods of administering effective amounts of an anti-arrhythmic agent, e.g., dantrolene, azumolene or a pharmaceutically acceptable salt thereof, for the acute treatment of cardiac arrhythmias, e.g., atrial fibrillation, premature ventricular contraction, ventricular tachycardia or ventricular fibrillation, and prevention of subsequent cardiac arrhythmias, wherein the methods effectuate a reduction in morbidity and mortality.

公开(公告)号：EP2996554A4

公开(公告)日：2017-02-15

申请号：EP14798103

申请日：2014-05-16

Applicant: UNIV HEALTH NETWORK

Inventor： NANTHAKUMAR KUMARASWAMY ,  DOWNAR EUGENE ,  MASSE STEPHANE

IPC: A61B5/0472 ,  A61B5/00 ,  A61B5/042 ,  A61B5/0432 ,  A61B5/0452 ,  A61B5/0464 ,  A61B34/10

CPC classification number: A61B34/10 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/0464 ,  A61B5/0472 ,  A61B5/6852 ,  A61B5/686 ,  A61B5/6869 ,  A61B2034/105 ,  A61B2505/05

Abstract: Various embodiments are described herein for a system and a method for identifying the arrhythmogenic circuit of a patient or subject. In one embodiment, the method comprises obtaining data for electrograms recorded at various locations of the heart while programmed ventricular pacing with extra stimuli was performed, obtaining decrement values for at least two different locations of the heart using the recorded electrograms, generating at least a portion of a decrement map using the decrement values, and identifying the arrhythmogenic circuit based on electrograms having significant decremental properties.

公开(公告)号：CA2946253C

公开(公告)日：2022-08-09

申请号：CA2946253

申请日：2014-05-05

Applicant: UNIV HEALTH NETWORK

Inventor： NANTHAKUMAR KUMARASWAMY

IPC: A61K31/4178 ,  A61K31/422 ,  A61P9/00 ,  A61P9/06

Abstract: The present description relates to methods of administering effective amounts of an anti-arrhythmic agent, e.g., dantrolene, azumolene or a pharmaceutically acceptable salt thereof, for the acute treatment of cardiac arrhythmias, e.g., atrial fibrillation, premature ventricular contraction, ventricular tachycardia or ventricular fibrillation, and prevention of subsequent cardiac arrhythmias, wherein the methods effectuate a reduction in morbidity and mortality.

公开(公告)号：CA3135685A1

公开(公告)日：2020-11-12

申请号：CA3135685

申请日：2020-05-06

Applicant: UNIV HEALTH NETWORK

Inventor： NANTHAKUMAR KUMARASWAMY

IPC: A61N1/05 ,  A61N1/362 ,  A61N1/365

Abstract: A multi-electrode implantable device for sensing cardiac signals and various methods for using the sensed cardiac signals are described herein. The multi-electrode device comprises a tetrahedral electrode cluster at a tip at a distal end of the lead/device; four electrodes embedded in the tetrahedral configuration; and four individual wires extending from the electrodes within the lead for receiving voltages sensed by the four electrodes. The methods can be used for deriving various physiological features that can be used in various ways including: diagnosing a physiological condition, efficient sensing of physiological signals, applying more efficient pacing by a pacemaker and indirect cardiac mapping. One or more of the physiological features may be used for applying appropriate treatment methods by a pacemaker/ICD or for applying cardiac ablation or cryofreezing.

公开(公告)号：EP2994134A4

公开(公告)日：2017-01-18

申请号：EP14803784

申请日：2014-05-05

Applicant: UNIV HEALTH NETWORK

Inventor： NANTHAKUMAR KUMARASWAMY

IPC: A61K31/4178 ,  A61K31/422 ,  A61P9/00 ,  A61P9/06

CPC classification number: A61K31/4178 ,  A61K31/422 ,  A61K45/06 ,  A61K2300/00

Abstract: The present description relates to methods of administering effective amounts of an anti-arrhythmic agent, e.g., dantrolene, azumolene or a pharmaceutically acceptable salt thereof, for the acute treatment of cardiac arrhythmias, e.g., atrial fibrillation, premature ventricular contraction, ventricular tachycardia or ventricular fibrillation, and prevention of subsequent cardiac arrhythmias, wherein the methods effectuate a reduction in morbidity and mortality.

Abstract translation: 本说明书中涉及施用抗心律不齐剂的有效量，例如，丹曲林，azumolene或药学上可接受的盐，其用于治疗急性心脏心律不齐，例如心房纤维性颤动，室性期前收缩，室性心动过速或心室的方法 纤维性颤动，和预防心律失常随后，worin方法实行中发病率和死亡率的降低。