公开(公告)号：CA2934729C

公开(公告)日：2021-08-17

申请号：CA2934729

申请日：2015-01-28

Applicant: UNIV HEALTH NETWORK

Inventor： HIRANO NAOTO ,  NAKATSUGAWA MUNEHIDE ,  OCHI TOSHIKI

IPC: C07K14/725 ,  A61K38/17 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02

Abstract: Provided is a method for determining a TCR polypeptide chain that can form a TCR specific for a peptide of interest. Also provided are methods and compositions for producing a cell expressing a T cell receptor (TCR) specific for a peptide of interest, methods and compositions for producing a TCR chain nucleic acid and/or pair of TCR chain polypeptides and/or nucleic acids encoding a TCR, a cell population comprising the cell harboring the nucleic acids encoding a TCR obtained by said method, and a method for treating a disorder comprising administering to the subject said cell population.

公开(公告)号：CA2934729A1

公开(公告)日：2015-08-06

申请号：CA2934729

申请日：2015-01-28

Applicant: UNIV HEALTH NETWORK

Inventor： HIRANO NAOTO ,  NAKATSUGAWA MUNEHIDE ,  OCHI TOSHIKI

IPC: C07K14/725 ,  A61K38/17 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02

Abstract: Provided is a method for determining a TCR polypeptide chain that can form a TCR specific for a peptide of interest. Also provided are methods and compositions for producing a cell expressing a T cell receptor (TCR) specific for a peptide of interest, methods and compositions for producing a TCR chain nucleic acid and/or pair of TCR chain polypeptides and/or nucleic acids encoding a TCR, a cell population comprising the cell harboring the nucleic acids encoding a TCR obtained by said method, and a method for treating a disorder comprising administering to the subject said cell population.

公开(公告)号：EP3099708A4

公开(公告)日：2017-07-05

申请号：EP15744002

申请日：2015-01-28

Applicant: UNIV HEALTH NETWORK

Inventor： HIRANO NAOTO ,  NAKATSUGAWA MUNEHIDE ,  OCHI TOSHIKI

IPC: C07K14/725 ,  A61K38/17 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02

CPC classification number: C07K14/7051 ,  A61K38/00 ,  C12N15/1037 ,  C12N15/1055

Abstract: Provided is a method for determining a TCR polypeptide chain that can form a TCR specific for a peptide of interest. Also provided are methods and compositions for producing a cell expressing a T cell receptor (TCR) specific for a peptide of interest, methods and compositions for producing a TCR chain nucleic acid and/or pair of TCR chain polypeptides and/or nucleic acids encoding a TCR, a cell population comprising the cell harboring the nucleic acids encoding a TCR obtained by said method, and a method for treating a disorder comprising administering to the subject said cell population.

Abstract translation: 提供了一种确定可形成对感兴趣肽特异的TCR的TCR多肽链的方法。 还提供了用于产生表达对感兴趣肽特异的T细胞受体（TCR）的细胞的方法和组合物，用于产生TCR链核酸和/或TCR链多肽对和/或编码 TCR，包含携带编码通过所述方法获得的TCR的核酸的细胞的细胞群，以及用于治疗病症的方法，所述方法包括向所述受试者施用所述细胞群。