公开(公告)号：WO0102425A3

公开(公告)日：2001-07-12

申请号：PCT/CA0000773

申请日：2000-06-29

Applicant: UNIV HEALTH NETWORK ,  PRIVE GIL

Inventor： PRIVE GIL

IPC: A61K38/16 ,  C07K14/00 ,  C07K14/705

CPC classification number: A61K38/16 ,  C07K14/001 ,  C07K14/705

Abstract: The present invention provides a novel class of detergents referred to herein as lipopeptide detergents. Lipopeptide detergents comprise an amphipathic alpha -helical peptide having a hydrophobic or neutral face and a hydrophilic face. To each end of this peptide is covalently linked an aliphatic hydrocarbon tail, these aliphatic tails being linked thereto such that they associate with the hydrophobic or neutral face of the peptide. Lipopeptide detergents can advantageously be used to stabilize membrane proteins in the absence of a phospholipid bilayer in a manner that preserves the native conformation and permits the subsequent crystallization thereof.

Abstract translation: 本发明提供了一类新型的洗涤剂，在本文中称为脂肽洗涤剂。 脂肽洗涤剂包含具有疏水或中性面和亲水面的两亲α-螺旋肽。 该肽的每个末端与脂肪族烃尾部共价连接，这些脂肪族尾部与其连接，使得它们与肽的疏水或中性面相连。 脂肽洗涤剂可有利地用于在不存在磷脂双分子层的情况下以保留天然构象并允许随后结晶的方式稳定膜蛋白。

公开(公告)号：CA2376650C

公开(公告)日：2008-01-15

申请号：CA2376650

申请日：2000-06-29

Applicant: UNIV HEALTH NETWORK

Inventor： PRIVE GIL

IPC: C11D3/33 ,  A61K38/16 ,  C07K14/00 ,  C07K14/705

Abstract: The present invention provides a novel class of detergents referred to herei n as lipopeptide detergents. Lipopeptide detergents comprise an amphipathic .alpha.-helical peptide having a hydrophobic or neutral face and a hydrophil ic face. To each end of this peptide is covalently linked an aliphatic hydrocarbon tail, these aliphatic tails being linked thereto such that they associate with the hydrophobic or neutral face of the peptide. Lipopeptide detergents can advantageously be used to stabilize membrane proteins in the absence of a phospholipid bilayer in a manner that preserves the native conformation and permits the subsequent crystallization thereof.

公开(公告)号：AU5668100A

公开(公告)日：2001-01-22

申请号：AU5668100

申请日：2000-06-29

Applicant: UNIV HEALTH NETWORK

Inventor： PRIVE GIL

IPC: A61K38/16 ,  C07K14/00 ,  C07K14/705 ,  C07K1/00

Abstract: The present invention provides a novel class of detergents referred to herein as lipopeptide detergents. Lipopeptide detergents comprise an amphipathic alpha-helical peptide having a hydrophobic or neutral face and a hydrophilic face. To each end of this peptide is covalently linked an aliphatic hydrocarbon tail, these aliphatic tails being linked thereto such that they associate with the hydrophobic or neutral face of the peptide. Lipopeptide detergents can advantageously be used to stabilize membrane proteins in the absence of a phospholipid bilayer in a manner that preserves the native conformation and permits the subsequent crystallization thereof.

公开(公告)号：CA2376650A1

公开(公告)日：2001-01-11

申请号：CA2376650

申请日：2000-06-29

Applicant: UNIV HEALTH NETWORK

Inventor： PRIVE GIL

IPC: A61K38/16 ,  C07K14/00 ,  C07K14/705

Abstract: The present invention provides a novel class of detergents referred to herei n as lipopeptide detergents. Lipopeptide detergents comprise an amphipathic .alpha.-helical peptide having a hydrophobic or neutral face and a hydrophil ic face. To each end of this peptide is covalently linked an aliphatic hydrocarbon tail, these aliphatic tails being linked thereto such that they associate with the hydrophobic or neutral face of the peptide. Lipopeptide detergents can advantageously be used to stabilize membrane proteins in the absence of a phospholipid bilayer in a manner that preserves the native conformation and permits the subsequent crystallization thereof.